DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and Galnt17

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_660253.2	Gene:	Galnt17 / 212996	MGIID:	2137594	Length:	598	Species:	Mus musculus

Alignment Length:	641	Identity:	211/641 - (32%)
Similarity:	322/641 - (50%)	Gaps:	106/641 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIIFILVALC-FILY-SKVQQNGSPEEPPVAPLVRAAALRGHGRERFE-----AYSDSENEIARP 69
            |::..|:|:. |::: :|.:        |:|  ||:.......|.|.|     |:|.|..:.|..
Mouse    10 LLVLNLIAVAGFVIFLAKCR--------PIA--VRSGDAFHEIRPRAEVANLSAHSASPIQDAVL 64

  Fly    70 ATQSPYEQII--QLDLQKQKVGL-------GEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLT 125
            ...|..|.|:  ||:...:.:||       |:.|:...||.:.:|:....::|...|..|||:::
Mouse    65 KRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPSEEEKAKGPHEKYGYNSYLSEKIS 129

  Fly   126 YNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDG 190
            .:||:.|:|...|.:.:: |..||..|::.||.||..||:||:|||.::......|||||||||.
Mouse   130 LDRSIPDYRPTKCKELKY-SKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDN 193

  Fly   191 SDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCE 255
            ||..||.|.|:.||..|.| |.|.::|.:.|.||||||:.|.:.|||.|..|.|||.|...||.|
Mouse   194 SDEEELKAPLEEYVHKRYP-GLVKVVRNQKREGLIRARIEGWKAATGQVTGFFDAHVEFTAGWAE 257

  Fly   256 PLLQRIKESRTSVLVPIIDVIDANDFQY-----STNGYKSFQVGGFQWNGHFDWINLPEREKQRQ 315
            |:|.||:|:|..|::|.||.|..::|:.     |.:|| |:::.....:...||.:..:..
Mouse   258 PVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGY-SWELWCMYISPPKDWWDAGDPS---- 317

  Fly   316 RRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIP 380
                      .|..:|.|.|..|.::|::|.|:|..|..||.:||||:|:..::|.|||::|.:|
Mouse   318 ----------LPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLP 372

  Fly   381 CSRVGHIFRDFHPYK----FPNDRDTHGINTARMALVWMDEYINIFFL--NRPDLKFHADIGDVT 439
            ||||.||.|...||.    |...|     |..|:|.||||:|.:..::  |.|......|||||:
Mouse   373 CSRVAHIERKKKPYNSNIGFYTKR-----NALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVS 432

  Fly   440 HRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKP-------- 496
            .|..|||.|:||:|:|||.::|||             :...|:.|...:|..|..|.
Mouse   433 ERKALRKSLKCKNFQWYLDHVYPE-------------MRRYNNTIAYGELRNNKAKDVCLDQGPL 484

  Fly   497 --YNAGLYPC---GKVLQKSQLFSFTN-----TNVLRNELSCATVQHSES--PPYRVVMVPCME- 548
              :.|.||||   |..|.:.....|.:     |..|..:..| .|.:|:|  |.    ::.|.:
Mouse   485 ENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRC-LVDNSKSRLPQ----LLDCDKV 544

  Fly   549 NDEFNEQWRY-EHQHIIHSNTGMCL--DHQGLKSLDDAQVAPCDPHSESQRWTIEH 601
            .....::|.: ::..|::..||.||  :::||..: |..:..|    ..|||.|::
Mouse   545 KSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGI-DLILRSC----TGQRWAIKN 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	116/289 (40%)
		pp-GalNAc-T	152..461	CDD:133004	132/319 (41%)
		Ricin_B_lectin	474..597	CDD:279046	32/146 (22%)
		RICIN	481..599	CDD:238092	34/141 (24%)
Galnt17	NP_660253.2	Catalytic subdomain A	151..262		58/111 (52%)
		pp-GalNAc-T	155..454	CDD:133004	132/319 (41%)
		Catalytic subdomain B	319..381		29/61 (48%)
		RICIN	467..593	CDD:238092	32/135 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810