DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and Galnt6

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001155239.1	Gene:	Galnt6 / 207839	MGIID:	1891640	Length:	622	Species:	Mus musculus

Alignment Length:	538	Identity:	217/538 - (40%)
Similarity:	289/538 - (53%)	Gaps:	63/538 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GEQGVA------VHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVG-DHRNPLCAKQRF-DSDS 147
            |..|.|      .:|....||.|   |||...|...|::::..||:| |.|.|.|..|:| ....
Mouse   114 GADGKAFQKKEWTNLETKEKEEG---YKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPP 175

  Fly   148 LPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYV-RTRIPSG 211
            |||.||:|:|.||.:|.|||||:|.|.|.....|||||||||.|.:..|..:|:.|| :.:|
Mouse   176 LPTTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDASTDEHLKERLEQYVQQLQI--- 237

  Fly   212 KVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVI 276
             |.::|.:.|.|||.|||.||.:|..:||.|||||||...||.||||.||.|.:|:|:.|.|..|
Mouse   238 -VRVVRQRERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTAVVSPDIVTI 301

  Fly   277 DANDFQYS--TNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFA 339
            |.|.||:|  ....|:...|.|.|:..|.|..|||.||||::      .|..|..|||.|||||:
Mouse   302 DLNTFQFSRPVQRGKAHSRGNFDWSLTFGWEMLPEHEKQRRK------DETYPIKSPTFAGGLFS 360

  Fly   340 IDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHG 404
            |.:.||..:|:||.||:.|||||:|||||:|||||.:|.||||.|||:||...|:.||.......
Mouse   361 ISKAYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIA 425

  Fly   405 INTARMALVWMDEYINIFF---LNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFV 466
            .|..|:|.||||:|..||:   |....:....:.||::.|:.||::|||.:|.|||.|:|||.||
Mouse   426 RNQVRLAEVWMDDYKKIFYRRNLQAAKMVQENNFGDISERLRLREQLRCHNFSWYLHNVYPEMFV 490

  Fly   467 PTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNEL----- 526
            |..:...:|.:..:.:|.|| |:.:||.......:|.|.. |..:|.|.:|:...||:.:
Mouse   491 PDLNPTFYGAIKNLGTNQCL-DVGENNRGGKPLIMYVCHN-LGGNQYFEYTSQRDLRHNIGKQLC 553

  Fly   527 -----------SCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHII-HSNTGMCLDHQGLKS 579
                       ||..|..:...|.             :|:|......:| :|.:|.||..|..|
Mouse   554 LHASGSTLGLRSCQFVGKNSRVPK-------------DEEWELTQDQLIRNSGSGTCLTSQDKK- 604

  Fly   580 LDDAQVAPCDPHSESQRW 597
               ..:|||:|....|.|
Mouse   605 ---PAMAPCNPRDPYQLW 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	143/284 (50%)
		pp-GalNAc-T	152..461	CDD:133004	153/314 (49%)
		Ricin_B_lectin	474..597	CDD:279046	33/139 (24%)
		RICIN	481..599	CDD:238092	33/134 (25%)
Galnt6	NP_001155239.1	Catalytic subdomain A	176..285		60/112 (54%)
		pp-GalNAc-T	180..485	CDD:133004	153/314 (49%)
		Catalytic subdomain B	348..410		40/61 (66%)
		Ricin_B_lectin	497..619	CDD:366226	33/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261568at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920