DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant1 and gly-3

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_498722.1	Gene:	gly-3 / 176112	WormBaseID:	WBGene00001628	Length:	612	Species:	Caenorhabditis elegans

Alignment Length:	633	Identity:	217/633 - (34%)
Similarity:	332/633 - (52%)	Gaps:	76/633 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSFYGKLIIFILVALCFILY----SKVQQNGSPEE-------PPVAPLVRAAALRGHGRERFEAY 59
            |:.....|:::|:.:..:.|    |..||...||:       ..:.||..||          :..
Worm    13 RAVIATSIVWLLIDVVILFYYLDPSTSQQQPFPEDNRILNRARRIEPLPPAA----------QHD 67

  Fly    60 SDSENEIARPATQSPYEQIIQLD----------LQKQKVG---LGEQGVAVHLSGAAKERGDEIY 111
            ||.:....:|..|.  :|:..:|          ::.|..|   .|:.|..|.:....|...::.:
Worm    68 SDPDAHPIQPEKQE--KQVYPVDKETANQLRKLMETQAFGPGYHGQGGTGVTVPEDKKTIKEKRF 130

  Fly   112 KKIALNEELSEQLTYNRSVGDHRNPLC--AKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLS 174
            .:...|...||.::.||::.|:|:..|  :.....:..:|..|::|:|.||.::.||||:||.::
Worm   131 LENQFNVVASEMISVNRTLPDYRSDACRTSGNNLKTAGMPKTSIIIVFHNEAWTTLLRTLHSVIN 195

  Fly   175 TCNEKALKEIILVDDGSDNVELGAKLDYYVRT-RIPSGKVTILRLKNRLGLIRARLAGARIATGD 238
            ......|:|||||||.||...|...||.|::. .||   :.::.|:||.|||||||.|:.:|.|.
Worm   196 RSPRHLLEEIILVDDKSDRDYLVKPLDSYIKMFPIP---IHLVHLENRSGLIRARLTGSEMAKGK 257

  Fly   239 VLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFD 303
            :|:|||||.|...||.|||:.|:.|.|..|:.||||||..:.|:|.|....::  |||.|:.:|.
Worm   258 ILLFLDAHVEVTDGWLEPLVSRVAEDRKRVVAPIIDVISDDTFEYVTASETTW--GGFNWHLNFR 320

  Fly   304 WINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFR 368
            |..:|:||..|:    ..:|.: |..:||:||||||||:::|:::|||||.|..|||||||:|||
Worm   321 WYAVPKRELNRR----GSDRSM-PIQTPTIAGGLFAIDKQFFYDIGSYDEGMQVWGGENLEISFR 380

  Fly   369 IWQCGGTIETIPCSRVGHIFRDFHPYKFPND--RDTHGINTARMALVWMDEYINIFFLNRPDLKF 431
            :|.|||::|..|||||||:||...||.||..  :..|. |.||.|.||||||...|:...|..:
Worm   381 VWMCGGSLEIHPCSRVGHVFRKQTPYTFPGGTAKVIHH-NAARTAEVWMDEYKAFFYKMVPAAR- 443

  Fly   432 HADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKP 496
            :.:.|||:.|..||:.|:||||:|||:|||||..:|. |.:..|.:....:..|:|   .|.:|.
Worm   444 NVEAGDVSERKKLRETLQCKSFKWYLENIYPEAPLPA-DFRSLGAIVNRFTEKCVD---TNGKKD 504

  Fly   497 YNA-GLYPC----GKVLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVPC-MENDEFNEQ 555
            ..| |:..|    |     :|.:|.|....:|::..|.:..|.......:.:..| :........
Worm   505 GQAPGIQACHGAGG-----NQAWSLTGKGEIRSDDLCLSSGHVYQIGSELKLERCSVSKINVKHV 564

  Fly   556 WRYEHQ--HIIHSNTGMCLDHQGLK-SLDDAQVAPCDPHSESQRWTIE 600
            :.::.|  .::|..||.|:.....: :||:     |....:.|.|.:|
Worm   565 FVFDDQAGTLLHKKTGKCVTGADQRVTLDE-----CGLGRKDQMWQLE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	135/281 (48%)
		pp-GalNAc-T	152..461	CDD:133004	150/311 (48%)
		Ricin_B_lectin	474..597	CDD:279046	25/131 (19%)
		RICIN	481..599	CDD:238092	25/126 (20%)
gly-3	NP_498722.1	pp-GalNAc-T	173..473	CDD:133004	150/311 (48%)
		Glyco_tranf_2_2	173..438	CDD:287123	134/275 (49%)
		Ricin_B_lectin	486..604	CDD:279046	25/130 (19%)
		RICIN	486..604	CDD:238092	25/130 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920