DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant1 and GALNTL5

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_016867282.1	Gene:	GALNTL5 / 168391	HGNCID:	21725	Length:	496	Species:	Homo sapiens

Alignment Length:	467	Identity:	185/467 - (39%)
Similarity:	243/467 - (52%)	Gaps:	52/467 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FYGKLIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSE---NEIARP 69
            |||.|...|..||.||.   :..|            ..::.:...:|...|:|..:   .:|...
Human    63 FYGSLTFGIWTALLFIY---LHHN------------HVSSWQKKSQEPLSAWSPGKKVHQQIIYG 112

  Fly    70 ATQSPYEQII--QLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYK---KIALNEELSEQLTYNRS 129
            :.|.|...:|  :.|..|.|..||..         ......|::|   |...|..:|..|...|.
Human   113 SEQIPKPHVIVKRTDEDKAKSMLGTD---------FNHTNPELHKELLKYGFNVIISRSLGIERE 168

  Fly   130 VGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNV 194
            |.|.|:.:|.::.:.: .|||||:||.|:||..:.|.:|:.|..:......|:|||||||.|...
Human   169 VPDTRSKMCLQKHYPA-RLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVD 232

  Fly   195 ELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQ 259
            :|..||||::.|.  .|||.|:|.|.|.|||||||.||..|:||||:|||:|||.|..|.||||.
Human   233 DLKEKLDYHLETF--RGKVKIIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLH 295

  Fly   260 RIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQERE 324
            .|.:....|:.|:|||||....:|..:   ....|.|.||..|.|.|:...|........|
Human   296 AIAKDPKMVVCPLIDVIDDRTLEYKPS---PLVRGTFDWNLQFKWDNVFSYEMDGPEGSTK---- 353

  Fly   325 ICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFR 389
              |..||.|:||:|||.|.||.|:|.||:.||.||.||||:|.|||.|||.:..|||||||||.:
Human   354 --PIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISK 416

  Fly   390 DFHPYKFPN---DRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCK 451
              .....|:   ...||  |..|:..||:|||...|||.:|.||: ...|::..||.|||:|.||
Human   417 --KQTGKPSTIISAMTH--NYLRLVHVWLDEYKEQFFLRKPGLKY-VTYGNIRERVELRKRLGCK 476

  Fly   452 SFEWYLKNIYPE 463
            ||:|||.|::||
Human   477 SFQWYLDNVFPE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	132/281 (47%)
		pp-GalNAc-T	152..461	CDD:133004	146/311 (47%)
		Ricin_B_lectin	474..597	CDD:279046
		RICIN	481..599	CDD:238092
GALNTL5	XP_016867282.1	GT2	187..437	CDD:224137	123/264 (47%)
GALNTL5	XP_016867282.1	pp-GalNAc-T	190..486	CDD:133004	146/311 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820