DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and Galnt4

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_056552.1	Gene:	Galnt4 / 14426	MGIID:	894692	Length:	578	Species:	Mus musculus

Alignment Length:	607	Identity:	232/607 - (38%)
Similarity:	325/607 - (53%)	Gaps:	61/607 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IIFILVALCFIL--YSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPY 75
            ::..|:.|.:||  :|......||         .|...|..|..|.......|.::::|....|
Mouse    13 LLLALLTLAYILVEFSVSTLYASP---------GAGGARELGPRRLPDLDTREEDLSQPLYIKP- 67

  Fly    76 EQIIQLDLQKQKVGLGEQGVAVHL---SGAAKERGDEIYKKIALNEELSEQLTYNRSVGDHRNPL 137
                    ......|||.|.|..|   .|..|:: :|:.::.|:|..||::::.:|.:.|.|...
Mouse    68 --------PADSHALGEWGRASKLQLNEGELKQQ-EELIERYAINIYLSDRISLHRHIEDKRMYE 123

  Fly   138 CAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDY 202
            |..::|...||||.||:|.|:||.:|.||||:||.|.|.....|||||||||.||.:.|.|:|:.
Mouse   124 CKAKKFHYRSLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRIYLKAQLET 188

  Fly   203 YVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTS 267
            |:..   ..:|.::|...|.||:||||.||..||||||.|||.|||.|.||.||||:||....|:
Mouse   189 YISN---LERVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNTGWLEPLLERISRDETA 250

  Fly   268 VLVPIIDVIDANDFQ-YSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSP 331
            ::.|:||.||.|.|: |...|..  .:|||.|...|.|.::|:.|:.|      :...|.|..||
Mouse   251 IVCPVIDTIDWNTFEFYMQTGEP--MIGGFDWRLTFQWHSVPKHERDR------RTSRIDPIRSP 307

  Fly   332 TMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKF 396
            ||||||||:.::||..:|:||..|:.|||||||:|||:|||||.:|..|||.|||:|....||..
Mouse   308 TMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYAR 372

  Fly   397 PNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIY 461
            ||...    ||||.|.||||||...|:...|..:..| .||::.|.:||::|:||||:|||||::
Mouse   373 PNFLQ----NTARAAEVWMDEYKEHFYNRNPPARKEA-YGDLSERKLLRERLKCKSFDWYLKNVF 432

  Fly   462 PEKFVPTKDVQGW-GKVHAVN-SNICLD-DLLQNNEKPYNAGLYPC-GKVLQKSQLFSFTNTNVL 522
            ....|| :|..|| |.:.::. |:.||| :...||....|..|:.| |:  ..:|.|.:|:...:
Mouse   433 SNLHVP-EDRPGWHGAIRSMGISSECLDYNAPDNNPTGANLSLFGCHGQ--GGNQFFEYTSNKEI 494

  Fly   523 R----NELSCATVQHSESPPYRVVMVPCMEND---EFNEQWRY-EHQHIIHSNTGMCLD-HQGLK 578
            |    .|| ||.|...:.   .|.|..|.::.   ..|..|.: |...|.|.:|.:||. ::..:
Mouse   495 RFNSVTEL-CAEVPQQKD---YVGMQNCPKDGLPVPVNIIWHFKEDGTIFHPHTRLCLSAYRTAE 555

  Fly   579 SLDDAQVAPCDPHSESQRWTIE 600
            ......:..||...::|.|..|
Mouse   556 GRPSVHMKTCDALDKNQLWRFE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	142/279 (51%)
		pp-GalNAc-T	152..461	CDD:133004	155/309 (50%)
		Ricin_B_lectin	474..597	CDD:279046	35/135 (26%)
		RICIN	481..599	CDD:238092	34/129 (26%)
Galnt4	NP_056552.1	WcaA	133..430	CDD:223539	157/312 (50%)
		Catalytic subdomain A	134..243		63/111 (57%)
		pp-GalNAc-T	138..432	CDD:133004	155/309 (50%)
		Catalytic subdomain B	303..365		39/61 (64%)
		RICIN	446..576	CDD:238092	35/135 (26%)
		Ricin_B_lectin	446..574	CDD:279046	34/133 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820