Protein Alignment Pgant1 and Galnt3

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_056551.2
• Gene: Galnt3 / 14425
• MGIID: 894695
• Length: 633
• Species: Mus musculus
• Alignment Length: 668
• Identity: 230/668 - (34%)
• Similarity: 320/668 - (47%)
• Gaps: 134/668 - (20%)

  Fly     6 RSFY--GKLIIFILVALCF------ILYSKVQ-------------------------------QN 31
            |.|:  |.:|.|.||.|..      :.|||.:                               |.
Mouse    18 RKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDFMLEAVNNIKDAMPKMQI 82

  Fly    32 GSP--------EEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPYEQIIQLDLQKQKV 88
            |:|        |.|.:.....||.|    :..|:......|  |..|:..|: :|..|..::||
Mouse    83 GAPIKENIDVRERPCLQGYYTAAEL----KPVFDRPPQDSN--APGASGKPF-KITHLSPEEQK- 139

  Fly    89 GLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVG-DHRNPLCAKQRFD-SDSLPTA 151
                          .||||:   .|...|...|::::.:|.:| |.|.|.|.:|:|. ...|||.
Mouse   140 --------------EKERGE---TKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTT 187

  Fly   152 SVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTIL 216
            ||:|:|.||.:|.|||||||.|.:.....|||||||||.|.:..|..||:.|::   ....|.|:
Mouse   188 SVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIK---QFSIVKIV 249

  Fly   217 RLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDF 281
            |.:.|.|||.|||.||.:||.:.|.|||||||...||.||||.||.|:.|:|:.|.|..||.|.|
Mouse   250 RQQERKGLITARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTF 314

  Fly   282 Q------YSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAI 340
            :      |.:|..:    |.|.|:..|.|.:||:.||||::      .|..|..:||.|||||:|
Mouse   315 EFNKPSPYGSNHNR----GNFDWSLSFGWESLPDHEKQRRK------DETYPIKTPTFAGGLFSI 369

  Fly   341 DRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGI 405
            .::||..:|||||:|:.|||||:|||||:|||||.:|.:|||.|||:||...|:.||........
Mouse   370 SKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKGTQVIAR 434

  Fly   406 NTARMALVWMDEYINIFFLNRPD---LKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVP 467
            |..|:|.||||||..||:....|   :......||::.|..::|:|:||:|.|||..||||.:||
Mouse   435 NQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYVP 499

  Fly   468 TKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNEL------ 526
            ..:....|.:.:|...:|| |:.:||:......||.| ..|..:|.|.::....:|:.:
Mouse   500 DLNPVISGYIKSVGQPLCL-DVGENNQGGKPLILYTC-HGLGGNQYFEYSAQREIRHNIQKELCL 562

  Fly   527 ----------SCATVQHSESPPYRVVMVPCMENDEFNEQ-WRYEHQHIIHSNT-GMCLDHQGLKS 579
                      :|....|....|              .|| |......::::.. .|||...|
Mouse   563 HATQGVVQLKACVYKGHRTIAP--------------GEQIWEIRKDQLLYNPLFKMCLSSNG--- 610

  Fly   580 LDDAQVAPCDPHSESQRW 597
             :...:.|||.....|:|
Mouse   611 -EHPNLVPCDATDLLQKW 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	149/317 (47%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	29/148 (20%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..145		11/50 (22%)
		Catalytic subdomain A	184..293		60/111 (54%)
		pp-GalNAc-T	188..493	CDD:133004	149/317 (47%)
		Catalytic subdomain B	356..418		39/61 (64%)
		beta-trefoil_Ricin-like	502..630	CDD:483949	29/146 (20%)