DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and Galnt3

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_056551.2	Gene:	Galnt3 / 14425	MGIID:	894695	Length:	633	Species:	Mus musculus

Alignment Length:	668	Identity:	230/668 - (34%)
Similarity:	320/668 - (47%)	Gaps:	134/668 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSFY--GKLIIFILVALCF------ILYSKVQ-------------------------------QN 31
            |.|:  |.:|.|.||.|..      :.|||.:                               |.
Mouse    18 RKFWKLGAVIFFFLVVLILMQREVSVQYSKEESKMERNLKNKNKMLDFMLEAVNNIKDAMPKMQI 82

  Fly    32 GSP--------EEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPYEQIIQLDLQKQKV 88
            |:|        |.|.:.....||.|    :..|:......|  |..|:..|: :|..|..::||
Mouse    83 GAPIKENIDVRERPCLQGYYTAAEL----KPVFDRPPQDSN--APGASGKPF-KITHLSPEEQK- 139

  Fly    89 GLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVG-DHRNPLCAKQRFD-SDSLPTA 151
                          .||||:   .|...|...|::::.:|.:| |.|.|.|.:|:|. ...|||.
Mouse   140 --------------EKERGE---TKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTT 187

  Fly   152 SVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTIL 216
            ||:|:|.||.:|.|||||||.|.:.....|||||||||.|.:..|..||:.|::   ....|.|:
Mouse   188 SVIIVFHNEAWSTLLRTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIK---QFSIVKIV 249

  Fly   217 RLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDF 281
            |.:.|.|||.|||.||.:||.:.|.|||||||...||.||||.||.|:.|:|:.|.|..||.|.|
Mouse   250 RQQERKGLITARLLGAAVATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTF 314

  Fly   282 Q------YSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAI 340
            :      |.:|..:    |.|.|:..|.|.:||:.||||::      .|..|..:||.|||||:|
Mouse   315 EFNKPSPYGSNHNR----GNFDWSLSFGWESLPDHEKQRRK------DETYPIKTPTFAGGLFSI 369

  Fly   341 DRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGI 405
            .::||..:|||||:|:.|||||:|||||:|||||.:|.:|||.|||:||...|:.||........
Mouse   370 SKKYFEHIGSYDEEMEIWGGENIEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKGTQVIAR 434

  Fly   406 NTARMALVWMDEYINIFFLNRPD---LKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVP 467
            |..|:|.||||||..||:....|   :......||::.|..::|:|:||:|.|||..||||.:||
Mouse   435 NQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEAYVP 499

  Fly   468 TKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNEL------ 526
            ..:....|.:.:|...:|| |:.:||:......||.| ..|..:|.|.::....:|:.:
Mouse   500 DLNPVISGYIKSVGQPLCL-DVGENNQGGKPLILYTC-HGLGGNQYFEYSAQREIRHNIQKELCL 562

  Fly   527 ----------SCATVQHSESPPYRVVMVPCMENDEFNEQ-WRYEHQHIIHSNT-GMCLDHQGLKS 579
                      :|....|....|              .|| |......::::.. .|||...|
Mouse   563 HATQGVVQLKACVYKGHRTIAP--------------GEQIWEIRKDQLLYNPLFKMCLSSNG--- 610

  Fly   580 LDDAQVAPCDPHSESQRW 597
             :...:.|||.....|:|
Mouse   611 -EHPNLVPCDATDLLQKW 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	140/284 (49%)
		pp-GalNAc-T	152..461	CDD:133004	149/317 (47%)
		Ricin_B_lectin	474..597	CDD:279046	28/140 (20%)
		RICIN	481..599	CDD:238092	27/135 (20%)
Galnt3	NP_056551.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..145		11/50 (22%)
		WcaA	184..>302	CDD:223539	64/120 (53%)
		Catalytic subdomain A	184..293		60/111 (54%)
		pp-GalNAc-T	188..493	CDD:133004	149/317 (47%)
		Catalytic subdomain B	356..418		39/61 (64%)
		Ricin_B_lectin	506..627	CDD:279046	28/140 (20%)
		RICIN	507..629	CDD:238092	29/141 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920