DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and GALNT15

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_473451.3	Gene:	GALNT15 / 117248	HGNCID:	21531	Length:	639	Species:	Homo sapiens

Alignment Length:	498	Identity:	185/498 - (37%)
Similarity:	263/498 - (52%)	Gaps:	38/498 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LNEELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKA 180
            |.|.||.::...|::.:.|:|||.:|. ..||||||||::.|.:|.:|.|||||||.|.|.....
Human   159 LQEALSARIPLQRALPEVRHPLCLQQH-PQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAF 222

  Fly   181 LKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDA 245
            |||||||||.|...:|.:.|..|| .|:..  |.:||...|||.||||:.||..||||||:|:||
Human   223 LKEIILVDDLSQQGQLKSALSEYV-ARLEG--VKLLRSNKRLGAIRARMLGATRATGDVLVFMDA 284

  Fly   246 HCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPER 310
            |||.:.||.||||.||...|:.|:.|:|||||...|||..:  |..|.|...|...|.|..|||.
Human   285 HCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYPS--KDLQRGVLDWKLDFHWEPLPEH 347

  Fly   311 EKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGT 375
            .::      ..:..|.|..||.:.|.:.|:||.||...|:||..|...||||||:||:.|.|||:
Human   348 VRK------ALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGS 406

  Fly   376 IETIPCSRVGHIF--RDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDL--KFHADIG 436
            :|.:||||||||:  :|.|.   |.|::....|..|:|..|:..:...|:.:.|:.  ...|:..
Human   407 VEILPCSRVGHIYQNQDSHS---PLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKP 468

  Fly   437 DVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGL 501
            |...|:.|:::|.|::|.|:|.|:|||.:.........||:|.....:|.|...:.:.......|
Human   469 DCMERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVL 533

  Fly   502 YPCGKVLQKSQLFSFTNTNVLRNELSCATVQH------SESPPYRVVMVPCMENDEFNEQWRYEH 560
            .||....|:..|     .:..|.|:...:.||      .|    :|::..|.|......|..::.
Human   534 APCSDSRQQQYL-----QHTSRKEIHFGSPQHLCFAVRQE----QVILQNCTEEGLAIHQQHWDF 589

  Fly   561 QH---IIHSNTGMCLDHQGLKSLDDAQVAPCDPHSESQRWTIE 600
            |.   |:|..:|.|::....::..|..:.|||..:. |:|..:
Human   590 QENGMIVHILSGKCMEAVVQENNKDLYLRPCDGKAR-QQWRFD 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	130/280 (46%)
		pp-GalNAc-T	152..461	CDD:133004	136/312 (44%)
		Ricin_B_lectin	474..597	CDD:279046	29/131 (22%)
		RICIN	481..599	CDD:238092	27/126 (21%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..155
		Catalytic subdomain A	190..299		63/111 (57%)
		Glyco_tranf_2_3	191..447	CDD:290369	127/269 (47%)
		pp-GalNAc-T	194..493	CDD:133004	136/312 (44%)
		Catalytic subdomain B	358..420		34/61 (56%)
		Ricin_B_lectin	505..628	CDD:279046	29/132 (22%)
		RICIN	507..630	CDD:238092	30/132 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820