DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant1 and GALNT6

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_009141.2	Gene:	GALNT6 / 11226	HGNCID:	4128	Length:	622	Species:	Homo sapiens

Alignment Length:	523	Identity:	210/523 - (40%)
Similarity:	276/523 - (52%)	Gaps:	65/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 KERGDEIYKKIALNEELSEQLTYNRSVG-DHRNPLCAKQRF-DSDSLPTASVVIIFFNEPYSVLL 166
            ||.|   |||...|...|::::..||:| |.|.|.|..|:| ....|.|.||:|:|.||.:|.||
Human   133 KEEG---YKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTSVIIVFHNEAWSTLL 194

  Fly   167 RTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAG 231
            |||:|.|.|.....|||||||||.|....|..||:.||:   ....|.::|.:.|.|||.|||.|
Human   195 RTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVK---QLQVVRVVRQEERKGLITARLLG 256

  Fly   232 ARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQ---- 292
            |.:|..:||.|||||||...||.||||.||.|.:|.|:.|.|..||.|.|:::    |..|
Human   257 ASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVTIDLNTFEFA----KPVQRGRV 317

  Fly   293 --VGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQM 355
              .|.|.|:..|.|..||..||||::      .|..|..|||.|||||:|.:.||..:|:||.||
Human   318 HSRGNFDWSLTFGWETLPPHEKQRRK------DETYPIKSPTFAGGLFSISKSYFEHIGTYDNQM 376

  Fly   356 DGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYIN 420
            :.|||||:|||||:|||||.:|.||||.|||:||...|:.||........|..|:|.||||.|..
Human   377 EIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDSYKK 441

  Fly   421 IFF---LNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNS 482
            ||:   |....:......||::.|:.||::|.|.:|.|||.|:|||.|||......:|.:..:.:
Human   442 IFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWYLHNVYPEMFVPDLTPTFYGAIKNLGT 506

  Fly   483 NICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNEL----------------SC-AT 530
            |.|| |:.:||.......:|.| ..|..:|.|.:|....||:.:                || .|
Human   507 NQCL-DVGENNRGGKPLIMYSC-HGLGGNQYFEYTTQRDLRHNIAKQLCLHVSKGALGLGSCHFT 569

  Fly   531 VQHSESPPYRVVMVPCMENDEFNEQWRYEHQHII-HSNTGMCLDHQGLKSLDDAQVAPCDPHSES 594
            .::|:.|.              :|:|......:| :|.:|.||..|..|    ..:|||:|....
Human   570 GKNSQVPK--------------DEEWELAQDQLIRNSGSGTCLTSQDKK----PAMAPCNPSDPH 616

  Fly   595 QRW 597
            |.|
Human   617 QLW 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	140/287 (49%)
		pp-GalNAc-T	152..461	CDD:133004	150/317 (47%)
		Ricin_B_lectin	474..597	CDD:279046	34/140 (24%)
		RICIN	481..599	CDD:238092	34/135 (25%)
GALNT6	NP_009141.2	Catalytic subdomain A	176..285		59/111 (53%)
		pp-GalNAc-T	180..485	CDD:133004	150/317 (47%)
		Catalytic subdomain B	348..410		40/61 (66%)
		Ricin_B_lectin	497..619	CDD:306998	34/141 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D261568at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020