DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRPK and SKY1

DIOPT Version :9

Sequence 1:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_013943.1	Gene:	SKY1 / 855256	SGDID:	S000004829	Length:	742	Species:	Saccharomyces cerevisiae

Alignment Length:	749	Identity:	261/749 - (34%)
Similarity:	370/749 - (49%)	Gaps:	147/749 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 APSSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQ------AKAKPNTQKE-----HQQQPPR 128
            ||:.:..|.|..|:.:|:|:.|:.    |.....||:      .|.||::..|     .....|:
Yeast    54 APTKSKLSLALQTSKSSSSANGTV----QEDTSSKTEDFSTKSIKKKPDSGVESHVSIQSDSGPQ 114

  Fly   129 SSSN-ESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHD-RYHVIRKLGWGHFSTVWLCWDLQ 191
            |.|: :|..|.:..|..::|.::||..|||||...|:.:.| ||.::|||||||||||||..|:.
Yeast   115 SDSDLDSDSSISSCDERNEESLKDYRPGGYHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMV 179

  Fly   192 AMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRR-----HKTVQMLDDFKITGVNGTHI 251
            ...:||:|||:....:.|.|.||||:|:.|.:.|  |.:.     :..:::||.|...|.||.|:
Yeast   180 NNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDAD--NTKEDSMGANHILKLLDHFNHKGPNGVHV 242

  Fly   252 CMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEP 316
            .|||||||:|||.||:|..:|||||..||.|::|:|.||||:|..|.||||||||||||:.:.:.
Yeast   243 VMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGDV 307

  Fly   317 HVRSLATEATQLYCMNSKMYPSLVSRAP------------KEYREPPITGKMSKNRKKKLKKKAK 369
            .......||.......:|.....|||:.            .|.:.....|..|.::.:.::|...
Yeast   308 EGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLS 372

  Fly   370 KRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFD-----ANSVEDNVHVAAGQPSRK 429
            ||  .|::.|.:......|...:|....|          :|:     ..|..::....:|
Yeast   373 KR--CFRRPRRHTIITGSQPLPSPISSSN----------FFEMRAHFCGSSHNSFSSVSG----- 420

  Fly   430 QREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESS---S 491
               .|..|                        ...|.|..|...|     ::||.:|..:|   |
Yeast   421 ---NRNIP------------------------SSINNNSINNGIG-----IKNSNNSFLNSVPHS 453

  Fly   492 ALK---SQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSD 553
            ..:   ::.:|.:|:..|:|:..|                             |||||..|:|.|
Yeast   454 VTRMFINEDSNDNNNNDNSKNKNN-----------------------------NNNNSNNNNNED 489

  Fly   554 ------------SKISSGSVEN--TSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVK 604
                        ..:|:..:.|  .||.||||:.::|:       .:......|....|..:.:|
Yeast   490 IMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTM-------DSNSNVSTDINSPENLIQIK 547

  Fly   605 IADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESY 669
            |||||||||.|.|:|..||||:|||.||::||.:...||||||||::|||.|||:||||..|.||
Yeast   548 IADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSY 612

  Fly   670 TRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAA 734
            |:|:||:|.||||||.:|..:|.||.|....|.....|||||.||.|.|.|||.|||::|:.:|.
Yeast   613 TKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAK 677

  Fly   735 SFASFLTPMLEFDPNKRATAAECLQHPWLRXDTM 768
            ..:.||:|||:.||.|||.|...:.||||: ||:
Yeast   678 EISDFLSPMLQLDPRKRADAGGLVNHPWLK-DTL 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	82/164 (50%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	92/162 (57%)
SKY1	NP_013943.1	PKc_like	155..706	CDD:419665	227/637 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I554
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2039
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000847
OrthoInspector	1	1.000	-	-		otm46738
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2294
SonicParanoid	1	1.000	-	-		X594
TreeFam	1	0.960	-	-
	11	10.750