DRSC/TRiP Functional Genomics Resources

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Protein Alignment SRPK and Cilk1

DIOPT Version :10

Sequence 1:NP_001369087.1 Gene:SRPK / 36706 FlyBaseID:FBgn0286813 Length:1009 Species:Drosophila melanogaster
Sequence 2:NP_620241.1 Gene:Cilk1 / 84411 RGDID:71050 Length:629 Species:Rattus norvegicus


Alignment Length:543 Identity:110/543 - (20%)
Similarity:199/543 - (36%) Gaps:158/543 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 DRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRH 232
            :||..|::||.|.:.:|.|...:::...:|||.:|...:..|...: ::.:|::::.:.:|..:.
  Rat     2 NRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN-LREVKSLKKLNHANIVKL 65

  Fly   233 KTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCC 297
            |.|...:|         |:..:||.:.:||.:||::.| :..|.:.::.|..|:|:||.::|. .
  Rat    66 KEVIREND---------HLYFIFEYMKENLYQLIKERN-KLFPESAIRNIMYQILQGLAFIHK-H 119

  Fly   298 KIIHTDIKPENVLLCVDEPHVR----SLATE-----------ATQLY------------------ 329
            ...|.|:|||| |||:....|:    .||.|           :|:.|                  
  Rat   120 GFFHRDLKPEN-LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDV 183

  Fly   330 ----CMNSKMY------PSL-----------VSRAPKEYREP---PITGKMS--------KNRKK 362
                |:.:::|      |..           |...||:...|   .::..|:        .|.|.
  Rat   184 WAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKT 248

  Fly   363 KLKKKAKKRMELFKQ--QRDYLEQADGQGAINPNEVQNG-DAGISDADEYFDANSVEDNV----H 420
            .:...:.:.::|.:.  |.|..::.....|:.....|.| ..|||..|.......|:|..    :
  Rat   249 LIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPY 313

  Fly   421 VAAGQPSR---------KQREERKAPP---------------EQSEEAQEQDP------------ 449
            |....|::         ..|..:.:.|               ||....||..|            
  Rat   314 VKPAPPAQAPTKAHTLISSRPNQASQPHQHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLHNKN 378

  Fly   450 ----LTEGTDKAKKKKKKKNKNK----SNQSKGQQP----PQLENSTSSA--------------- 487
                :..|.::.....|.|::.:    |..:||...    ..|:.|:|..               
  Rat   379 LPPKILAGLEQKSGDMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPL 443

  Fly   488 ---ESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPN 549
               ||...||..:..|:.::.:.::::....|...||..|:..|:..:...|.|.:   |...||
  Rat   444 CRFESVLDLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIR---NGVLPN 505

  Fly   550 SNSD----SKISSGSVENTSSAT 568
            ...|    |..||..:...||.|
  Rat   506 PGKDFLPSSSWSSSGLSGKSSGT 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SRPKNP_001369087.1 Protein Kinases, catalytic domain 159..>318 CDD:473864 42/149 (28%)
Protein Kinases, catalytic domain <600..763 CDD:473864
Cilk1NP_620241.1 STKc_MAK_like 4..284 CDD:270824 61/292 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..322 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 454..482 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..629
Blue background indicates that the domain is not in the aligned region.

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