Protein Alignment SRPK and SRPK2

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_024302662.1
• Gene: SRPK2 / 6733
• HGNCID: 11306
• Length: 767
• Species: Homo sapiens
• Alignment Length: 844
• Identity: 344/844 - (40%)
• Similarity: 452/844 - (53%)
• Gaps: 209/844 - (24%)

  Fly     9 RVLAIQAKKKRHKNRKRGKQNGTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHL 73
            |||||||:|:|.|..|..|:    |:.|..:.....|.|...|.|.|        .||
Human    42 RVLAIQARKRRPKREKHPKK----PEPQQKAPLVPPPPPPPPPPPPP--------LPD------- 87

  Fly    74 NAPSSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESE 138
              |:                                                ||     |..|..
Human    88 --PT------------------------------------------------PP-----EPEEEI 97

  Fly   139 TFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKS 203
            ..||:|:||...||||||||||.|||||:.|||||||||||||||||||||:|...:||:|:|||
Human    98 LGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKS 162

  Fly   204 APHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRK 268
            |.|:.|||.||||:||.|||:|||:|.:...||::|||||:|:||.|:||||||||.:|||.|.|
Human   163 AQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIK 227

  Fly   269 SNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNS 333
            |||:|:|:..||:|.||||:||||||:.||||||||||||:|:|||:.:||.:|.|||:  ...:
Human   228 SNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATE--WQKA 290

  Fly   334 KMYP---SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQG------ 389
            ...|   |.||.||   ::.|| ||:|||:|||||||.|::.||.:::...:|:.:.:.
Human   291 GAPPPSGSAVSTAP---QQKPI-GKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIE 351

  Fly   390 ----AINPNEVQNGD---------AGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQS 441
                :..|:..|:|:         .|:.:|.|   |.:.:||.. |..|..::..|:.....::.
Human   352 ENITSAAPSNDQDGEYCPEVKLKTTGLEEAAE---AETAKDNGE-AEDQEEKEDAEKENIEKDED 412

  Fly   442 EEAQE---------QDPLTEG-------------TDKAKKKKKKKNKNKSNQSKGQQPPQLENST 484
            :..||         :.|.|.|             .|:...::...|..:.|..:    |..|:..
Human   413 DVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDE----PNAESDY 473

  Fly   485 SSAESSSALKSQQANGSNSTTNNK----SNTNSSGTLKGQSNGKKM----PLRPKQEKQGSNHQL 541
            :.:.|......:..||.:....::    |.:..||:|:..:.|..:    ||..::|
Human   474 TYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEE-------- 530

  Fly   542 NNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKK---DPALDECN--- 600
                |.|:.:....:|:.|..:.                   |:||.:|..   :| ||..|
Human   531 ----SSPSHDRSRTVSASSTGDL-------------------PKAKTRAADLLVNP-LDPRNADK 571

  Fly   601 VHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHS 665
            :.||||||||||||.:|||||||||||||:||:|||||:|.|||||||||.||||||||||||||
Human   572 IRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHS 636

  Fly   666 GESYTRDEDHLAHIIELLGPIPREILLN-------------------------------GTYAAK 699
            ||.|:|||||:||||||||.|||...|:                               |.|:.:
Human   637 GEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGKYSKE 701

  Fly   700 SFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            .|||..|||:|:.||||.|.|||:|||.|..:|||.|..||.||||..|.|||:|.|||:||||
Human   702 FFTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	111/158 (70%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	118/196 (60%)
SRPK2	XP_024302662.1	Protein Kinases, catalytic domain	116..>304	CDD:473864	123/189 (65%)
		2A1904	<389..431	CDD:273344	8/42 (19%)
		Protein Kinases, catalytic domain	<552..765	CDD:473864	124/213 (58%)