Protein Alignment SRPK and SRPK1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_003128.3
• Gene: SRPK1 / 6732
• HGNCID: 11305
• Length: 655
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 330/691 - (47%)
• Similarity: 436/691 - (63%)
• Gaps: 85/691 - (12%)

  Fly   108 KKTQA---KAKPNTQKEHQQQPPRSSSN--ESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFH 167
            |:|:|   ||:..::.:|:...|.|.|:  |..|....||:::||...||||||||.|.|||||:
Human    13 KRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFN 77

  Fly   168 DRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRH 232
            .||||||||||||||||||.||:|...:||:|:||||.|:.|||.|||::||:||.:||::|.|.
Human    78 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNRE 142

  Fly   233 KTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCC 297
            ..||:||||||:|||||||||||||||.:|||.|.||||:|:||..||.|.:|||:|||||||.|
Human   143 MVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKC 207

  Fly   298 KIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYP---SLVSRAPKEYREPPITGKMSKN 359
            :||||||||||:||.|:|.::|.||.|||:  ...|...|   |.||.||    :|....|||||
Human   208 RIIHTDIKPENILLSVNEQYIRRLAAEATE--WQRSGAPPPSGSAVSTAP----QPKPADKMSKN 266

  Fly   360 RKKKLKKKAKKRMELFK---QQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHV 421
            :|||||||.|::.||.:   |:.:.:|:..|.|...||:.:..::.:.        ..:::|
Human   267 KKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVE--------RPLKEN--- 320

  Fly   422 AAGQPSRKQREERKAPPEQSEEAQEQDPL---TEG----------------TDKAKKK--KKKKN 465
                |..|..:|:.  .|.|...|:|..:   |||                |..:..:  :.|::
Human   321 ----PPNKMTQEKL--EESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKED 379

  Fly   466 KNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNT---NSSGTLKGQSNGKKMP 527
            .:.:|....|...| |:|..|:::..:..||:.:.....|:..|:|   .||.|: |||
Human   380 LHNANDCDVQNLNQ-ESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTV-GQS------ 436

  Fly   528 LRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKK 592
               ..|:..|..|.:.....|..:...:..:|.::|...:|.|    :.|..|..|..|:
Human   437 ---FSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAG----NFLVNPLEPKNAE----- 489

  Fly   593 DPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATG 657
                   .:.||||||||||||.:||||||||||||||||:||:||||.|||||||||.||||||
Human   490 -------KLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATG 547

  Fly   658 DYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVL 722
            ||||||||||.|||||||:|.||||||.:||::::.|.|:.:.||:..:|::|:.||||||.:||
Human   548 DYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVL 612

  Fly   723 LEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            :|||||||::||.|..||.||||..|.|||||||||:||||
Human   613 VEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	111/158 (70%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	117/162 (72%)
SRPK1	NP_003128.3	Protein Kinases, catalytic domain	69..>282	CDD:473864	139/218 (64%)
		Protein Kinases, catalytic domain	<477..653	CDD:473864	121/187 (65%)