Protein Alignment SRPK and srpk3

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_694973.8
• Gene: srpk3 / 566605
• ZFINID: ZDB-GENE-101025-2
• Length: 731
• Species: Danio rerio
• Alignment Length: 778
• Identity: 343/778 - (44%)
• Similarity: 431/778 - (55%)
• Gaps: 138/778 - (17%)

  Fly    16 KKKRHKNRKRGK----------QNGTNPQEQSNSS--------QNQNPKPSSNPIPEPN--RSSE 60
            ||::.||:|..|          .....||..|:..        ::..| |.|:|.|..|  :|..
Zfish    60 KKQKKKNKKHRKAAVAAAVEISSLELGPQIPSSDELCHILTIHRSATP-PESSPTPPLNLSQSPP 123

  Fly    61 NLQAPDNANNSHLNAPSSAAFSKATATA--TASTSSGGSAGTPD-QYQPPKKTQAKAKPNTQKEH 122
            :||.|....:|   .|.:...|....::  |.||....|.|.|. ....|...||.:...|..:.
Zfish   124 DLQPPAPIPHS---IPITVVPSPVVVSSPETPSTPIAPSLGLPSILSSTPPTPQAPSNQPTPPQA 185

  Fly   123 QQQPPRSSSNESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLC 187
            ...||...|....|. ..||:|:||...|||||||:||.|||||:.||||:||||||||||||||
Zfish   186 LSPPPPDFSPPPAEL-LGSDDEEQENPSDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLC 249

  Fly   188 WDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHIC 252
            ||||...:||:|:||||.|:.|||.||||:||.||::||::.:|.:.||::|||||:||||.|:|
Zfish   250 WDLQRKRFVALKVVKSAQHYTETALDEIKLLKCVRDSDPTDSKRERLVQLIDDFKISGVNGVHVC 314

  Fly   253 MVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPH 317
            ||.||||..|||.|.||||.|:||..||:|.||||||||||||.||||||||||||:||.|:|.:
Zfish   315 MVLEVLGHQLLKWIIKSNYMGLPLICVKSILRQVLEGLDYLHTKCKIIHTDIKPENILLEVNEVY 379

  Fly   318 VRSLATEATQLYCMNSKMYP--SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQ--- 377
            ||.||.||| ::.......|  |.||.||:|.:    .||||||:|||||:|||::.:|..:
Zfish   380 VRRLAAEAT-IWQKAGAPPPSGSSVSTAPREKQ----MGKMSKNKKKKLKRKAKRQQQLLDERLI 439

  Fly   378 --QRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQ 440
              ||  :|:.||   :.|::.......:....|     ..||||
Zfish   440 DLQR--MEELDG---VLPSDASGNTRALWRLSE-----DEEDNV--------------------- 473

  Fly   441 SEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTT 505
                                                                 |..|.|| |...
Zfish   474 -----------------------------------------------------KHAQTNG-NGAL 484

  Fly   506 NNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNG 570
            |.:|..:.|..|:...||.. |||......|.:   ..:.|..::.|:|.:|:.|..:|..:...
Zfish   485 NKQSPESGSSWLEESCNGYG-PLRFSSPGSGLS---GLSGSILSATSESALSTLSGYSTERSLLS 545

  Fly   571 PHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIG 635
            |:|.|.......|.::::..|         :.:|||||||||||.:||||||||||||:|||:||
Zfish   546 PNSYSAADFLVNPLESQNADK---------ISIKIADLGNACWVHKHFTEDIQTRQYRALEVLIG 601

  Fly   636 AGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKS 700
            |.|...|||||||||.||||||||||||||||.|||||||:||||||||.||....|:|.|:.:.
Zfish   602 AEYGPPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIAHIIELLGAIPPHFALSGRYSREY 666

  Fly   701 FTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            |.|..|||:|:.||||||.:||||||||....||.|:.||..||||.|.||||||:||||||:
Zfish   667 FNRRGELRHIANLKPWGLFEVLLEKYEWPLDQAAQFSDFLLTMLEFIPEKRATAAQCLQHPWI 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	112/158 (71%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	116/162 (72%)
srpk3	XP_694973.8	None