DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SRPK and Cilk1

DIOPT Version :10

Sequence 1:NP_001369087.1 Gene:SRPK / 36706 FlyBaseID:FBgn0286813 Length:1009 Species:Drosophila melanogaster
Sequence 2:NP_064371.2 Gene:Cilk1 / 56542 MGIID:1934157 Length:629 Species:Mus musculus


Alignment Length:593 Identity:116/593 - (19%)
Similarity:210/593 - (35%) Gaps:192/593 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 DRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRH 232
            :||..|::||.|.:.:|.|...:::...:|||.:|...:..|...: ::.:|::::.:.:|..:.
Mouse     2 NRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN-LREVKSLKKLNHANIVKL 65

  Fly   233 KTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCC 297
            |.|...:|         |:..:||.:.:||.:||::.| :..|.:.::.|..|:|:||.::|. .
Mouse    66 KEVIREND---------HLYFIFEYMKENLYQLIKERN-KLFPESAIRNIMYQILQGLAFIHK-H 119

  Fly   298 KIIHTDIKPENVLLCVDEPHVR----SLATE-----------ATQLY------------------ 329
            ...|.|:|||| |||:....|:    .||.|           :|:.|                  
Mouse   120 GFFHRDLKPEN-LLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDI 183

  Fly   330 ----CMNSKMY------PSL-----------VSRAPKEYREP---PITGKMS--------KNRKK 362
                |:.:::|      |..           |...||:...|   .::..|:        .|.|.
Mouse   184 WAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKT 248

  Fly   363 KLKKKAKKRMELFKQ--QRDYLEQADGQGAINPNEVQNG-DAGISDADEYFDANSVEDNV----H 420
            .:...:.:.::|.:.  |.|..::.....|:.....|.| ..||...|.......|:|..    :
Mouse   249 LIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGIISKDSGKPQREVQDKTGPPPY 313

  Fly   421 VAAGQPSR----------KQREERKAPP--------------EQSEEAQEQDP------------ 449
            :....|::          .:..:...||              ||....||..|            
Mouse   314 IKPAPPAQAPAKAYTLISSRPSQASQPPQHSVHPYKGDVSRTEQLSHVQEGKPSPPFFPSLHNKN 378

  Fly   450 --------LTEGTDKAKKKKKKKNKNKSNQSKG----------------------QQPPQLENST 484
                    |.:...:.|.|.:::....|..:||                      .:..|.:::.
Mouse   379 LQPKILASLEQKNGEIKPKSRRRWGLISRSTKGSDDWADLDDLDFSPSLTRIDVKNKKRQSDDTL 443

  Fly   485 SSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPN 549
            ...||...||..::.|:.:|.:.::::....|...||:.|:..|:..:...|.|.:   |...||
Mouse   444 CRFESVLDLKPSESVGTGTTVSTQASSQRRDTPTLQSSAKQHYLKHSRYLPGINIR---NGVLPN 505

  Fly   550 SNSD-----------------------SKISS-GSVENTSSATNGPHSNSTL------------- 577
            ...|                       |||:| ||...:||...|.:..|.|             
Mouse   506 PGKDFLPSNSWSSSGLSGKSSGTVSVVSKITSVGSGSASSSGLTGSYIPSFLKKEIGSVMQRVQL 570

  Fly   578 -PTPPPPP 584
             |...|||
Mouse   571 APLAAPPP 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SRPKNP_001369087.1 Protein Kinases, catalytic domain 159..>318 CDD:473864 42/149 (28%)
Protein Kinases, catalytic domain <600..763 CDD:473864
Cilk1NP_064371.2 STKc_MAK_like 4..284 CDD:270824 61/292 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..376 12/83 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..483 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 581..629
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.