DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRPK and Srpk79D

DIOPT Version :9

Sequence 1:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	279/738 - (37%)
Similarity:	390/738 - (52%)	Gaps:	117/738 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PR---SSSNESY----ESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTV 184
            ||   |:::|.|    :|..:..:|:||....||:||||||.|||:|.:|:.|:|||||||||||
  Fly   297 PRGTLSTTDEIYPDSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTV 361

  Fly   185 WLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGT 249
            |||.||:...|||:|:||||||:.|||.|||::|:.:|:.||.:.:|.:.|::::.|.:.||||.
  Fly   362 WLCRDLKDEKYVALKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGM 426

  Fly   250 HICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVD 314
            |.|:|||.||.:|.|||.|:||:|:.:|.|:.|.|||||||||||:.|.||||||||||:||.:|
  Fly   427 HTCLVFEALGCSLYKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVID 491

  Fly   315 ---------EPHVRSLATEATQL---YCMNSKMYPSLVSRAPKEYREPPITGKMSKNRKKKLKKK 367
                     :..:.||..:....   |.  |.:.....|||.....||..:...:.|........
  Fly   492 NAAAMNQQIDDEINSLRVKGVDFPDSYI--SSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATN 554

  Fly   368 AKKRMELFKQQRDYLEQAD----GQGAINPNEVQN-------------------GDAGIS----- 404
            :.....|.......|::.|    ....:|.|...:                   |.|.|:
  Fly   555 SNSSTPLAAVIMSTLDKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRT 619

  Fly   405 ----------DADEYFDANSVEDNVHVAAG-------QPSRKQREERKAPPEQSEEAQEQDPLTE 452
                      |.||..:::::.:...:|:.       .|..:...:....||.||....:.|...
  Fly   620 EKKITAKSSGDCDEDAESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPSEGPIPEQPTPN 684

  Fly   453 GTDK----------AKKKKKKK-----------------NKNKSNQSKGQQPPQLENSTSSAESS 490
            .|:.          ||.|....                 |.|.:..|....||       ||..|
  Fly   685 STNSSCPSHNTATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPP-------SATPS 742

  Fly   491 SALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSK 555
            ||.....|...::.|.:.:....|.|....|.    ......|....:|:..:.::...||:.|.
  Fly   743 SAPALASATPPSTCTPSFTQIAPSATAPATST----TCTTSAEFYDGDHKTTSTSTTTTSNAISS 803

  Fly   556 ISSGSVENTSS-ATNGPHSNSTLPTPPPPPQAKHKAKKD------PALDECNVHVKIADLGNACW 613
            .::.:...|:: |....|:|:.      |.|.:.::.::      ..:|..||.||||||||||:
  Fly   804 ATTTTATTTTAIAKLNVHANAI------PSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACY 862

  Fly   614 VDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAH 678
            ...|||||||||||||:||::||.||.:||||||||:.||||||||||:||:||||:||||||||
  Fly   863 DYHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGESYSRDEDHLAH 927

  Fly   679 IIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPM 743
            |:||||.||:.::..|.:..|.||....||||:.||||.||:||:|||:|...:|..|:.||.||
  Fly   928 IVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPM 992

  Fly   744 LEFDPNKRATAAECLQHPWLRXD 766
            ||::|..||:||||||||||. :
  Fly   993 LEYNPVIRASAAECLQHPWLEQE 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	94/167 (56%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	109/162 (67%)
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	94/167 (56%)
		S_TKc	347..>492	CDD:214567	86/144 (60%)
		STKc_SRPK	<844..1012	CDD:271038	110/167 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_KOG1290
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8407
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	P	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.770