Protein Alignment SRPK and Srpk1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_001020897.1
• Gene: Srpk1 / 361811
• RGDID: 1308272
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 714
• Identity: 333/714 - (46%)
• Similarity: 421/714 - (58%)
• Gaps: 136/714 - (19%)

  Fly   108 KKTQAKAKPNTQKEHQQQPPRSSSN--ESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRY 170
            ||.:|:.||.||  |:...|.|.|:  |..|....||:::||...||||||||.|.|||||:.||
  Rat    18 KKDKAQRKPETQ--HRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRY 80

  Fly   171 HVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTV 235
            ||||||||||||||||.||:|...:||:|:||||.|:.|||.|||::||:||.:||::|.....|
  Rat    81 HVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVV 145

  Fly   236 QMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKII 300
            |:||||||:|||||||||||||||.:|||.|.||||:|:||..||.|.:|||:|||||||.|:||
  Rat   146 QLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRII 210

  Fly   301 HTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYP---SLVSRAPKEYREPPITGKMSKNRKK 362
            ||||||||:||.|:|.::|.||.|||:  ...|...|   |.||.||    :|....|||||:||
  Rat   211 HTDIKPENILLSVNEQYIRRLAAEATE--WQRSGAPPPSGSAVSTAP----QPKPADKMSKNKKK 269

  Fly   363 KLKKKAKKRMELFK---QQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAG 424
            |||||.|::.||.:   |:.:.:|:..|.|...||
  Rat   270 KLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPN------------------------------ 304

  Fly   425 QPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAES 489
                 ::||.::|.|:        ||||..           .||..|.|      ||.|:|..:.
  Rat   305 -----KQEESESPVER--------PLTENP-----------PNKMTQEK------LEESSSIGQD 339

  Fly   490 SS-------------------ALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQ 535
            .:                   .:.:..||.:|.|...|.:.:::....|::        .|||.
  Rat   340 QTLTEHGGEGGAPEINCNGVIGIVNYTANSNNETLRLKEDLHNANDCDGRT--------LKQEP- 395

  Fly   536 GSNHQLNNNNSKPNSNSDSKISSGS-VENTSSATNGPHSNSTLP--------------TPPPPPQ 585
             |.....|.:|.|:..:||...||| |..|.:.......:.||.              ||....|
  Rat   396 -SFLSSPNGDSSPSPETDSCTPSGSEVPETMACQASVERSLTLTQQDITHLQERIRAHTPSGDEQ 459

  Fly   586 AK-HKAKKDP------------ALDECN---VHVKIADLGNACWVDRHFTEDIQTRQYRSLEVII 634
            .: |....|.            .|:..|   :.||||||||||||.:||||||||||||||||:|
  Rat   460 EREHNGALDSKGKFSAGNFLINPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLI 524

  Fly   635 GAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAK 699
            |:||||.|||||||||.||||||||||||||||.|||||||:|.||||||.:||::::.|.|:.:
  Rat   525 GSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKE 589

  Fly   700 SFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            .||:..:|::|:.||||||::||:|||||.|::||.|..||.||||..|.|||||||||:||||
  Rat   590 FFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	110/158 (70%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	117/165 (71%)
Srpk1	NP_001020897.1	Protein Kinases, catalytic domain	70..653	CDD:473864	306/658 (47%)