DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRPK and CG8565

DIOPT Version :9

Sequence 1:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	259/820 - (31%)
Similarity:	375/820 - (45%)	Gaps:	169/820 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VNRRVLAIQAKKKRHKNRKRGKQNGTNPQEQSNSSQNQNPKP------------------SSNPI 52
            :.|:...|:|.|:..:.:.|.:.......:..|:|..|:..|                  :||.:
  Fly    10 IRRKAAIIRASKRAFQEKIRKQMESCGVTQMGNASTQQSNVPMDVDADMGRKMSEDGMTDTSNTV 74

  Fly    53 PEPNRSSE-----NLQAPDNANNSHLNAPSSA-------AFSKATATATASTSSGGSAGTP---- 101
            .:|:.|.:     ..|.|..:.|........|       ...|......:|.|..|.||..
  Fly    75 KQPSCSKDQKQLSRKQKPSPSYNHQEQIEQRAKRPKICKKRCKQKRRMPSSLSDDGIAGRKPAKI 139

  Fly   102 DQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQELMEDYCKGGYHPVNIGDLF 166
            ::|.........:.|...|  ||.....::|::.|...|   :.||...:|..||||||.|||:|
  Fly   140 NKYSELSYGSESSMPFEMK--QQSNDNQNNNDNAEGSGF---DRQESANEYVIGGYHPVAIGDVF 199

  Fly   167 HDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRR 231
            .:||||.:|||||||||||||:|.|...|.|:|:.|||..:.||..|||.:...:...|....|.
  Fly   200 VNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSAQVYKETGIDEIMLFSQMSLHDQHKYRS 264

  Fly   232 HKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTC 296
            | .|...|.|:|||.:|.|||:|.|||||||||:|.:..|:|:|::|:|.|.:|||.||.:||..
  Fly   265 H-VVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERCFYKGMPISNIKQIAQQVLTGLKFLHEE 328

  Fly   297 CKIIHTDIKPENVLLCVDEPHVRSLATEATQLY--CMNSKMYPSLVSRAPKEYREPPITGKMSKN 359
            |.|||||:|||||||..:|..||:....|.::|  ....|:.||               .||:|.
  Fly   329 CGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLSPS---------------SKMTKT 378

  Fly   360 RKKKLKKKAKKRMELFKQQR---------DYLEQADGQGAINPNEVQNGDAGISDADEYFDANSV 415
            .|::::.|:||.:..||..|         |.|..|: :|.|.|...               |.:|
  Fly   379 AKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAE-RGLIEPITA---------------AMAV 427

  Fly   416 EDNV-HVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKK------------KN-- 465
            .||: .:..|........:......|:.:..|.:.:....|:.....|.            ||
  Fly   428 SDNLPFIPFGFDGFMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLKSPELFLRYVLDIIKNLD 492

  Fly   466 -KNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLR 529
             |..|.|.|                                 .:..|.:||  :||
  Fly   493 EKELSTQDK---------------------------------RRRFTQASG--RGQ--------- 513

  Fly   530 PKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDP 594
                            :|.|:.|..:::|.:...|.:   |..||..:......|       .||
  Fly   514 ----------------TKKNARSRLRLASNAAYTTGT---GWRSNRKINLNDIYP-------IDP 552

  Fly   595 ALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDY 659
            |.:||:|.||||||||||:...|||:||||::||:||||:||||..:|||||.||:::|||||.|
  Fly   553 ANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLLWELATGTY 617

  Fly   660 LFEPHSGE-SYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLL 723
            ||:.||.. .|..||.|:|.|:|..|.||..::..|.::......:.:|.||..|||..|.::|:
  Fly   618 LFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFINSAGKLCNIETLKPLKLANILI 682

  Fly   724 EKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            ..|.|..:.:..|.:||.|||:.:|..|.:|::.|:..:|
  Fly   683 RWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	87/158 (55%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	76/163 (47%)
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	220/631 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I930
eggNOG	1	0.900	-	-		E1_KOG1290
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I552
Isobase	1	0.950	-	0	Normalized mean entropy	S2039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm979
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	P	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.820