DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRPK and Srpk2

DIOPT Version :9

Sequence 1:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	XP_038963154.1	Gene:	Srpk2 / 296753	RGDID:	1305107	Length:	749	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	340/843 - (40%)
Similarity:	440/843 - (52%)	Gaps:	212/843 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KKRHKNRKRGKQN-----GTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHLNAP 76
            :|....||:.||.     ..| .|:|:||:...|:..:..:|.|
  Rat    21 RKERNIRKKIKQKIELLMSVN-SEKSSSSERPEPQQKAPLVPPP--------------------- 63

  Fly    77 SSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFS 141
                                        .||........|        .||     |..|....|
  Rat    64 ----------------------------PPPPPPPPLPDP--------VPP-----EPEEEILGS 87

  Fly   142 DNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPH 206
            |:|:||...||||||||||.|||||:.|||||||||||||||||||||:|...:||:|:||||.|
  Rat    88 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH 152

  Fly   207 FAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNY 271
            :.|||.||||:||.|||:|||:|.:...||::|||||:|:||.|:||||||||.:|||.|.||||
  Rat   153 YTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNY 217

  Fly   272 RGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMY 336
            :|:|:..||:|.||||:||||||:.||||||||||||:|:|||..:||.:|.|||:  ...:...
  Rat   218 QGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDGAYVRRMAAEATE--WQKAGAP 280

  Fly   337 P---SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQN 398
            |   |.||.||   ::.|| ||:|||:|||||||.|::.||.:::...:|:.:.:.
  Rat   281 PPSGSAVSTAP---QQKPI-GKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREA--------- 332

  Fly   399 GDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDK----AKK 459
                        :...:|:|  ..:.:.|.:|..|.: |..:.:||:.:|...|.|.|    .:.
  Rat   333 ------------ERKILEEN--TTSAEASSEQDGECQ-PEVKLKEAELEDTTEEETAKDNGEVED 382

  Fly   460 KKKKKNKNKSNQSKGQQ--PPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSN 522
            :::|::..|.|..|.:.  ..:|||.     ..:.::|.:|||.                  ..|
  Rat   383 QEEKEDTEKENTEKDEDDVEQELENI-----DPTWMESPKANGH------------------IEN 424

  Fly   523 GKKMPLRPKQEKQGSNHQLNN----NNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTP--- 580
            |..:..:..::::.......|    |..:||:.||...||...:......||...:...|||
  Rat   425 GLFLLEQQLEDEEDEEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQPKSPEFPTPLFS 489

  Fly   581 -PPPPQAKH----------------------------------KAKKDPA------LDECN---V 601
             |..|.|..                                  |.|...|      ||..|   :
  Rat   490 GPLEPVASDSVLSEGSPLTEPEESSPSRDRSRTVSASSTGDLPKTKTRAADLLVNPLDPQNADKI 554

  Fly   602 HVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSG 666
            .||||||||||||.:|||||||||||||:||:|||||:|.|||||||||.|||||||||||||||
  Rat   555 RVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSG 619

  Fly   667 ESYTRDEDHLAHIIELLGPIPREILLN-------------------------------GTYAAKS 700
            |.|:|||||:||||||||.|||...|:                               |.|:.:.
  Rat   620 EDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGKYSKEF 684

  Fly   701 FTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            |||..|||:|:.||||.|.|||:|||.|..:|||.|..||.||||..|.|||:|.|||:||||
  Rat   685 FTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	111/158 (70%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	118/196 (60%)
Srpk2	XP_038963154.1	PKc_like	103..>291	CDD:419665	123/189 (65%)
		2A1904	<338..417	CDD:273344	20/86 (23%)
		PKc_like	<538..747	CDD:419665	121/208 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2139
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1116
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	1	1.000	-	-		FOG0000847
OrthoInspector	1	1.000	-	-		otm45168
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X594
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730