Protein Alignment SRPK and Srpk3

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_006229620.1
• Gene: Srpk3 / 293854
• RGDID: 727856
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 697
• Identity: 304/697 - (43%)
• Similarity: 393/697 - (56%)
• Gaps: 136/697 - (19%)

  Fly    82 SKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQ 146
            ::|....|..::|.|.:|..|.......:|....|  :....:..|.:.:....:....||:|:|
  Rat    16 TRALGCDTRMSASAGGSGGMDCGGSSSSSQTSCGP--ESSSSELAPATPAPRLLQGLLGSDDEEQ 78

  Fly   147 ELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETA 211
            |..:|||||||:||.|||||:.||||:||||||||||||||||:|...:||:|:||||.|:.|||
  Rat    79 EDPKDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETA 143

  Fly   212 RDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTH--ICMVFEVLGDNLLKLIRKSNYRGI 274
            .||||:||.||::|||:|:|...||::|||:|:||||..  :|||.||||..|||.|.||||:|:
  Rat   144 VDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVRPDVCMVLEVLGHQLLKWIIKSNYQGL 208

  Fly   275 PLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYP-- 337
            |:..||:|.||||.|||||||.||||||||||||:||||.:.::|.||.|||:  ...|...|
  Rat   209 PVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATE--WQQSGAQPPS 271

  Fly   338 -SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQ-RDYLEQADGQGAINPNEVQNGD 400
             |.||.||:|..:   |||:|||::||:::|.|::..|.::: ||.
  Rat   272 RSTVSTAPQEVLQ---TGKLSKNKRKKMRRKRKQQKRLLEERLRDL------------------- 314

  Fly   401 AGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKN 465
                                                   |..||.|....||
  Rat   315 ---------------------------------------QRLEAMEAAVQTE------------- 327

  Fly   466 KNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMP--- 527
                                  :|||.|  :|.:||.|:    |..:..||..|.|.....|
  Rat   328 ----------------------DSSSRL--EQGSGSTSS----SGCHPEGTRAGPSPASSSPVPT 364

  Fly   528 -----LRPKQEKQGSNHQLNNNNS-KPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQA 586
                 |.|..:..|.:..|.:..| ...|.|.::..:|.:.:.|:    |...|.|...|..||.
  Rat   365 GGERSLSPSSQTSGFSGSLFSTASCSVLSGSSNQRETGGLLSPST----PFGASNLLVNPLEPQN 425

  Fly   587 KHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMV 651
            ..|.|           :|||||||||||.:||||||||||||::||:|||.|...|||||||||.
  Rat   426 ADKIK-----------IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMA 479

  Fly   652 FELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPW 716
            ||||||||||||||||.|:|||||:|||:||||.||....|:|.|:.:.|.|..|||:|..||.|
  Rat   480 FELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHW 544

  Fly   717 GLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            ||.:||:|||||..:.|..|::||.||:|:.|.|||:||:|||||||
  Rat   545 GLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	109/160 (68%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	108/162 (67%)
Srpk3	XP_006229620.1	Protein Kinases, catalytic domain	91..591	CDD:473864	281/618 (45%)