DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRPK and SRPK3

DIOPT Version :9

Sequence 1:	NP_001369087.1	Gene:	SRPK / 36706	FlyBaseID:	FBgn0286813	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_055185.2	Gene:	SRPK3 / 26576	HGNCID:	11402	Length:	567	Species:	Homo sapiens

Alignment Length:	691	Identity:	303/691 - (43%)
Similarity:	391/691 - (56%)	Gaps:	143/691 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TAST----SSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNE---------SYESETF 140
            :|||    .||||.|:      ...:||..           .|.||.:|         ..:....
Human     2 SASTGGGGDSGGSGGS------SSSSQASC-----------GPESSGSELALATPVPQMLQGLLG 49

  Fly   141 SDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAP 205
            ||:|:||..:||||||||||.|||:|:.||||:||||||||||||||||:|...:||:|:||||.
Human    50 SDDEEQEDPKDYCKGGYHPVKIGDVFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAG 114

  Fly   206 HFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSN 270
            |:.|||.||||:||.||::|||:|:|...||::|||:|:||||.|:|||.||||..|||.|.|||
Human   115 HYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSN 179

  Fly   271 YRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKM 335
            |:|:|:..||:|.||||.|||||||.||||||||||||:||||.:.::|.||.|||:  ...:..
Human   180 YQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATE--WQQAGA 242

  Fly   336 YP---SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQ 397
            .|   |:||.||:|..:   |||:|||::||:::|.|::..|.:::...|::.:...|....|
Human   243 PPPSRSIVSTAPQEVLQ---TGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAATQAE-- 302

  Fly   398 NGDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKK 462
              |:|:.     .|..|
Human   303 --DSGLR-----LDGGS------------------------------------------------ 312

  Fly   463 KKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMP 527
                 .|..|.|..|.......|.|.||.|     ..|..|.:.....:..||:|...::...:
Human   313 -----GSTSSSGCHPGGARAGPSPASSSPA-----PGGGRSLSAGSQTSGFSGSLFSPASCSIL- 366

  Fly   528 LRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKK 592
                                  |.|.::..:|.:.:.|:    |...|.|...|..||...|.|
Human   367 ----------------------SGSSNQRETGGLLSPST----PFGASNLLVNPLEPQNADKIK- 404

  Fly   593 DPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATG 657
                      :|||||||||||.:||||||||||||::||:|||.|...|||||||||.||||||
Human   405 ----------IKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATG 459

  Fly   658 DYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVL 722
            ||||||||||.|:|||||:|||:||||.||....|:|.|:.:.|.|..|||:|..||.|||.:||
Human   460 DYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNLKHWGLYEVL 524

  Fly   723 LEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            :|||||..:.|..|::||.||:|:.|.|||:||:|||||||
Human   525 MEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	PKc_like	159..>318	CDD:419665	109/158 (69%)
SRPK	NP_001369087.1	PKc_like	<600..763	CDD:419665	108/162 (67%)
SRPK3	NP_055185.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		14/50 (28%)
		STKc_SRPK3	68..565	CDD:271120	274/606 (45%)
		S_TKc	79..565	CDD:214567	267/595 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..283		18/47 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..351		16/119 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1051
Isobase	1	0.950	-	0	Normalized mean entropy	S2039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	1	1.000	-	-		FOG0000847
OrthoInspector	1	1.000	-	-		otm41032
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2294
SonicParanoid	1	1.000	-	-		X594
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.710