Protein Alignment SRPK and dsk1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_595327.1
• Gene: dsk1 / 2539847
• PomBaseID: SPBC530.14C
• Length: 544
• Species: Schizosaccharomyces pombe
• Alignment Length: 705
• Identity: 243/705 - (34%)
• Similarity: 323/705 - (45%)
• Gaps: 177/705 - (25%)

  Fly    94 SGGSAGTPDQYQP---------PKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQELM 149
            |.||:.:|...||         .:|.....| |..|:...:....|..|..::.       :|..
pombe     3 SDGSSLSPKVSQPGHTEIVDHVSEKVITNGK-NVNKKVNAEVDGKSMVEKVKTH-------EENA 59

  Fly   150 EDYCKGGYHPVNIGDLFHDRYHVI-RKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARD 213
            |||..||||||.||:.||.|.:|: |||||||||||||.:|..|...||:|:|:||.|:.||:.|
pombe    60 EDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSID 124

  Fly   214 EIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLAN 278
            ||:||:.:||.|..:..:...:.:||.|...|.||.|:||||||||:|||.||:...:||:|:..
pombe   125 EIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGI 189

  Fly   279 VKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRA 343
            ||.|..|:|..|||||..|.|||||:||||||:|:|:..::.:                    .|
pombe   190 VKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHI--------------------EA 234

  Fly   344 PKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADE 408
            |.....|......||.|
pombe   235 PATTSSPTSNTSSSKTR------------------------------------------------ 251

  Fly   409 YFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSK 473
                    :|....|..|..|:.:      .....|||            :|...||..|:::..
pombe   252 --------NNTGYTAKAPIIKRGQ------SVDNSAQE------------RKTFAKNPTKNSKPA 290

  Fly   474 GQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSN 538
            ||..|      ||..:|:..:.....|:.|                     ::.||..|:
pombe   291 GQVIP------SSPFTSTLSRFPSLEGAVS---------------------EISLRDSQK----- 323

  Fly   539 HQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHV 603
                 :||.||    |..|||.........||    |..|.|                   .:.|
pombe   324 -----HNSHPN----SPFSSGDNSLILDGVNG----SQEPVP-------------------KITV 356

  Fly   604 KIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGES 668
            ||||||||||..:|||.|:|||||||.|||:|..:..|||.||.||::|||.||||||:|.:|.|
pombe   357 KIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACIIFELLTGDYLFDPRNGNS 421

  Fly   669 YTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDA 733
            |::::||:|.|||||...|:::.|:|.::...|.|..|||||..||.|.|.|||.:||.:|.:.|
pombe   422 YSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQKYHFSAELA 486

  Fly   734 ASFASFLTPMLEFDPNKRATAAECLQHPWLRXDTMQPGCWLRATQPATADGDGGA 788
            ...:.||:|||.|||.||..|......|||| :...|...:..|.....|..|.|
pombe   487 QQISDFLSPMLCFDPAKRTNAGYMSNSPWLR-EVADPTFKIETTGATGEDVPGWA 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	87/159 (55%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	87/162 (54%)
dsk1	NP_595327.1	STKc_SRPK	69..516	CDD:271038	215/604 (36%)