Protein Alignment SRPK and CILK1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 159/802 - (19%)
• Similarity: 276/802 - (34%)
• Gaps: 265/802 - (33%)

  Fly   168 DRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRH 232
            :||..||:||.|.:.:|.|...:::...:|||.:|...:..|...: ::.:|::::.:.:|..:.
Human     2 NRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN-LREVKSLKKLNHANVVKL 65

  Fly   233 KTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCC 297
            |.|...:|         |:..:||.:.:||.:||::.| :..|.:.::.|..|:|:||.::|. .
Human    66 KEVIREND---------HLYFIFEYMKENLYQLIKERN-KLFPESAIRNIMYQILQGLAFIHK-H 119

  Fly   298 KIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRA----PKEYR-EPPITGKMS 357
            ...|.|:|||| |||                      |.|.||..|    .:|.| :||.|..:|
Human   120 GFFHRDLKPEN-LLC----------------------MGPELVKIADFGLAREIRSKPPYTDYVS 161

  Fly   358 KNRKKKLKKKAKKRMELFKQQRDYLEQAD--GQGAINPN--EVQNGDAGISDADEYFDANSVEDN 418
                    .:..:..|:..:..:|....|  ..|.|...  .::....|.|:.|..|....|
Human   162 --------TRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQV--- 215

  Fly   419 VHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENS 483
                .|.|                               ||....:....|:....:.|..:.|:
Human   216 ----LGTP-------------------------------KKTDWPEGYQLSSAMNFRWPQCVPNN 245

  Fly   484 TSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKG--QSNGKKMP-----LRPKQEKQGSNHQL 541
                     ||:...|.|:....         .|:.  |.:.||.|     ||....:.|  |.|
Human   246 ---------LKTLIPNASSEAVQ---------LLRDMLQWDPKKRPTASQALRYPYFQVG--HPL 290

  Fly   542 NNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIA 606
            .:...  |.....|...|.:|..     || .....|.||..|.||             .|.:|:
Human   291 GSTTQ--NLQDSEKPQKGILEKA-----GP-PPYIKPVPPAQPPAK-------------PHTRIS 334

  Fly   607 DLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTR 671
                             :||:::.:..:...|...|::..|
Human   335 -----------------SRQHQASQPPLHLTYPYKAEVSRT------------------------ 358

  Fly   672 DEDHLAHIIE-----LLGPI-----PREILLNGTYAAKSFTRSCELRNISGLKP-----WGLMD- 720
              ||.:|:.|     ||.|.     |:.:   .:..:...|...|.:| ..:||     |||:.
Human   359 --DHPSHLQEDKPSPLLFPSLHNKHPQSV---SSPDSPKITAGLEHKN-GEIKPKSRRRWGLISR 417

  Fly   721 VLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWLRXDTMQPGCWLRAT---QPATA 782
            ...:..:|:..|...|:..|: .::....||.:            ||:   |...:.   :|:..
Human   418 STKDSDDWADLDDLDFSPSLS-RIDLKNKKRQS-----------DDTL---CRFESVLDLKPSEP 467

  Fly   783 DGDGGALAGTGTGKGTRARAT-------------------ALKGGSPAVPADGEVGRGYI----- 823
            .|.|.: |.|.|....|...|                   :::.|..:.|     |:.:|
Human   468 VGTGNS-APTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNP-----GKEFIPPNPW 526

  Fly   824 -------ESSASVATLASISSI--ASTSAAAMAALKARPYL---VAPFVTTASAPPTPHPHASIS 876
                   :||.:::.::.::|:  :|||::.:.......:|   :...:......|.|.|....|
Human   527 SSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYS 591

  Fly   877 TSTA-RTAPATP---TRRRIAP 894
            :..| |..|..|   |:.|..|
Human   592 SLKAMRPHPGRPFFHTQPRSTP 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	43/149 (29%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	29/178 (16%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	81/378 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344		17/91 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639		8/25 (32%)