Protein Alignment SRPK and Srpk2

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_011248053.1
• Gene: Srpk2 / 20817
• MGIID: 1201408
• Length: 750
• Species: Mus musculus
• Alignment Length: 837
• Identity: 342/837 - (40%)
• Similarity: 445/837 - (53%)
• Gaps: 199/837 - (23%)

  Fly    17 KKRHKNRKRGKQN-----GTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHLNAP 76
            :|....||:.||.     ..| .|:|:||:...|:..:..:|.|
Mouse    21 RKERNIRKKIKQKTELLMSVN-SEKSSSSERPEPQQKAPLVPPP--------------------- 63

  Fly    77 SSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFS 141
                                   .|....||....|             ||     |..|....|
Mouse    64 -----------------------PPPPPPPPLPDPA-------------PP-----EPEEEILGS 87

  Fly   142 DNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPH 206
            |:|:||...||||||||||.|||||:.|||||||||||||||||||||:|...:||:|:||||.|
Mouse    88 DDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH 152

  Fly   207 FAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNY 271
            :.|||.||||:||.|||:|||:|.:...||::|||||:|:||.|:||||||||.:|||.|.||||
Mouse   153 YTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNY 217

  Fly   272 RGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMY 336
            :|:|:..||:|.||||:||||||:.||||||||||||:|:|||:.:||.:|.|||:  ...:...
Mouse   218 QGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATE--WQKAGAP 280

  Fly   337 P---SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQN 398
            |   |.||.||   ::.|| ||:|||:|||||||.|::.||.:::...:|:.:.:.
Mouse   281 PPSGSAVSTAP---QQKPI-GKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREA--------- 332

  Fly   399 GDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDK----AKK 459
                        :...:|:|  :.:.:.|.:|::....|....:.|..:|...|.|.|    .:.
Mouse   333 ------------ERKILEEN--ITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGEVED 383

  Fly   460 KKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGK 524
            :::|::..|.|..|.:.  .:|...::.: .:.::|.:|||...        |...:|:.|...:
Mouse   384 QEEKEDAEKENAEKDED--DVEQELANLD-PTWVESPKANGHIE--------NGPFSLEQQLEDE 437

  Fly   525 KMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTP----PPPPQ 585
            :     ..|...:|.: ..|..:||:.||...||...:......||.|..|..|||    |..|.
Mouse   438 E-----DDEDDCANPE-EYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPV 496

  Fly   586 A-------------------KH---------------KAKKDPA------LDECN---VHVKIAD 607
            |                   .|               |.|...|      ||..|   :.|||||
Mouse   497 ACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNADKIRVKIAD 561

  Fly   608 LGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRD 672
            |||||||.:|||||||||||||:||:|||||:|.|||||||||.||||||||||||||||.|:||
Mouse   562 LGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRD 626

  Fly   673 EDHLAHIIELLGPIPREILLN-------------------------------GTYAAKSFTRSCE 706
            |||:||||||||.|||...|:                               |.|:.:.|||..|
Mouse   627 EDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLGKVPRKYAMLGKYSKEFFTRKGE 691

  Fly   707 LRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            ||:|:.||||.|.|||:|||.|..:|||.|..||.||||..|.|||:|.|||:||||
Mouse   692 LRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	111/158 (70%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	118/196 (60%)
Srpk2	XP_011248053.1	Protein Kinases, catalytic domain	103..>291	CDD:473864	123/189 (65%)
		2A1904	<338..418	CDD:273344	16/84 (19%)
		Protein Kinases, catalytic domain	<537..748	CDD:473864	121/210 (58%)