Protein Alignment SRPK and Srpk1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_058075.2
• Gene: Srpk1 / 20815
• MGIID: 106908
• Length: 648
• Species: Mus musculus
• Alignment Length: 683
• Identity: 326/683 - (47%)
• Similarity: 422/683 - (61%)
• Gaps: 81/683 - (11%)

  Fly   108 KKTQAKAKPNTQKEHQQQPPRSSSN--ESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRY 170
            ||.:|:.||.||  |:...|.|.|:  |..|....||:::||...||||||||.|.|||||:.||
Mouse    18 KKDKAQRKPETQ--HRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRY 80

  Fly   171 HVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTV 235
            ||||||||||||||||.||:|...:||:|:||||.|:.|||.|||::||:||.:||::|.....|
Mouse    81 HVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVV 145

  Fly   236 QMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKII 300
            |:||||||:|||||||||||||||.:|||.|.||||:|:||..||.|.:|||:|||||||.|:||
Mouse   146 QLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRII 210

  Fly   301 HTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYP---SLVSRAPKEYREPPITGKMSKNRKK 362
            ||||||||:||.|:|.::|.||.|||:  ...|...|   |.||.||    :|....|||||:||
Mouse   211 HTDIKPENILLSVNEQYIRRLAAEATE--WQRSGAPPPSGSAVSTAP----QPKPADKMSKNKKK 269

  Fly   363 KLKKKAKKRMELFK---QQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAG 424
            |||||.|::.||.:   |:.:.:|:..|.|...||:.:..:   |..|.....|
Mouse   270 KLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESE---SPVDRPLTEN----------- 320

  Fly   425 QPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKN---------KNKSNQSKGQQPPQL 480
             |..|..:|:.   |:|....:...|||...:....:...|         :|.:|::. :....|
Mouse   321 -PPNKMTQEKL---EESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNYPENSNNETL-RHKEDL 380

  Fly   481 ENST-----SSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLR---PKQEKQGS 537
            .|:.     :..:..|.|.|...:.|.|...:.....:|.|:..||:.::...|   .:.|:...
Mouse   381 HNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIR 445

  Fly   538 NHQLNNNNSKPNSNSDS--KISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECN 600
            ....:.:..:||...||  |.|:|:.               |..|..|..|:            .
Mouse   446 ADTPSGDEQEPNGALDSKGKFSAGNF---------------LINPLEPKNAE------------K 483

  Fly   601 VHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHS 665
            :.||||||||||||.:||||||||||||||||:||:||||.|||||||||.||||||||||||||
Mouse   484 LQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHS 548

  Fly   666 GESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQ 730
            ||.|||||||:|.||||||.:||::::.|.|:.:.||:..:|::|:.||||||::||:|||||.|
Mouse   549 GEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQ 613

  Fly   731 KDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            ::||.|..||.||||..|.|||||||||:||||
Mouse   614 EEAAGFTDFLLPMLELMPEKRATAAECLRHPWL 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	110/158 (70%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	116/162 (72%)
Srpk1	NP_058075.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		15/40 (38%)
		Protein Kinases, catalytic domain	70..646	CDD:473864	299/627 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..354		40/137 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..464		15/68 (22%)
		Protein Kinases, catalytic domain	<470..537	CDD:473864	48/93 (52%)