Protein Alignment SRPK and spk-1

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_499080.3
• Gene: spk-1 / 176328
• WormBaseID: WBGene00004980
• Length: 1003
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 298/726 - (41%)
• Similarity: 381/726 - (52%)
• Gaps: 164/726 - (22%)

  Fly    45 PKPSSNPIPEPNRSSENLQAPDNANNSHLNAPSSAAFSKATATATASTSSGGSAGTPDQYQPPKK 109
            |:||.  ||..|:.:|     .|||...|:       ..:.:...:.:..||..|..|.:|.|
 Worm   336 PRPSI--IPRNNKKTE-----VNANEERLD-------DLSVSPGRSDSPGGGGGGHSDSFQDP-- 384

  Fly   110 TQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIR 174
                ..|..|                   ..||:|:||...||.:||||||||||:|:.||||||
 Worm   385 ----MDPGEQ-------------------LGSDDEEQEDPRDYKRGGYHPVNIGDVFNARYHVIR 426

  Fly   175 KLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLD 239
            ||||||||||||.||.|...:||:||||||.|:.|.|.||||:|.:||..||::...||.||:||
 Worm   427 KLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLD 491

  Fly   240 DFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDI 304
            :|.:||:||.|:.|||||||.||||||.:|||||:.|..|:.|.|||||.|.|:|..|.||||||
 Worm   492 EFTVTGINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDI 556

  Fly   305 KPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRAP----KEYREPPITGKMSKNRKKKLK 365
            ||||||:.:....::.:|..|.....||.||..|.||.||    |..:|     .|:||:|||:|
 Worm   557 KPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQE-----NMTKNKKKKMK 616

  Fly   366 KKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQ 430
            |||||:.|..:.:...||                  |:.     .|||.:::..:.|
 Worm   617 KKAKKQREKLEAELAGLE------------------GLK-----MDANGLQEAYNNA-------- 650

  Fly   431 REERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKS 495
                                                           |:|||..:|......::
 Worm   651 -----------------------------------------------PELENFNASQVEDVTME- 667

  Fly   496 QQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSK---IS 557
                   .|.|...|.|            |:.:|       |..:.:.....|.|:.:||   ::
 Worm   668 -------DTVNENGNRN------------KVEIR-------SPDRFDRTTLTPFSDPESKFGDLA 706

  Fly   558 SGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDI 622
            |.|.|..||..:.......||.||..|..     .||   .|::.||||||||||||:.|:|:||
 Worm   707 SPSAEYLSSPMSQLPPGGILPAPPVGPNI-----GDP---YCDIDVKIADLGNACWVNHHYTDDI 763

  Fly   623 QTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIP 687
            ||||||:|||:||:||...|||||||||.|||||||||||||.|::|:|||||||||.||||.||
 Worm   764 QTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIP 828

  Fly   688 REILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRA 752
            ..|...|.:..:.|.::..|.:|..||||.|.:||.:|||||.:||..|.|||.|||:||..||:
 Worm   829 PSIYKKGKHWREFFHKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRS 893

  Fly   753 TAAECLQHPWL 763
            ||...|:||:|
 Worm   894 TAKIALKHPFL 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	102/158 (65%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	103/162 (64%)
spk-1	NP_499080.3	STKc_SRPK	411..904	CDD:271038	267/610 (44%)