Protein Alignment SRPK and SRPK

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_061498458.1
• Gene: SRPK / 1276029
• VectorBaseID: AGAMI1_013127
• Length: 794
• Species: Anopheles gambiae
• Alignment Length: 830
• Identity: 377/830 - (45%)
• Similarity: 483/830 - (58%)
• Gaps: 105/830 - (12%)

  Fly     1 MN-KADVNRRVLAIQAKKKRHKN-RKRGKQNGT-----------------NPQEQSNSSQNQNPK 46
            || |.|.||.||.|||||||||. :|:.||..|                 |....|.|.||....
Mosquito     1 MNIKPDTNRHVLTIQAKKKRHKTAKKKAKQQATAVVAAAAAQAAAQAAAQNSNSYSRSGQNHQSA 65

  Fly    47 PSSNPI---PEPNRSSENLQAPDNANNSHLNAPSSAAFSKATATATASTSSGGSAGTPDQYQPPK 108
            .::..|   ......||..:..|:.::..:...:::..:.|..|.......||||....|:....
Mosquito    66 ATAGSIGGGAFVGGGSELHEHDDDDDHDDMILGTTSGAAAAGMTGGGGGGGGGSAMNDSQHSVSS 130

  Fly   109 KTQAK------AKPNTQKEHQQQPPRSSSNESYESE-------TFSDNEDQELMEDYCKGGYHPV 160
            ...|:      :|...|..|......|||||:.|.:       ..|:.|:||..||||:||||||
Mosquito   131 GGPAELVGRRGSKSAGQPHHHLDTTTSSSNETIEQDGDRDADGYTSEEEEQECREDYCRGGYHPV 195

  Fly   161 NIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETD 225
            .:||||..||||||||||||||||||.|||:...|||:||||||.||::||:|||.|||::...|
Mosquito   196 KLGDLFLQRYHVIRKLGWGHFSTVWLSWDLEEKRYVALKIVKSAQHFSDTAKDEIHILKSITNAD 260

  Fly   226 PSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGL 290
            |::|:|:|.||:|:||:|||||||||||||||||.||||||.|||||||||||||:|.|||||||
Mosquito   261 PADPKRNKVVQLLNDFRITGVNGTHICMVFEVLGHNLLKLIMKSNYRGIPLANVKSIIRQVLEGL 325

  Fly   291 DYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGK 355
            |||||.||||||||||||||:||:|.:||.||.|||:::.|..|:..||:|.||.:::|.|::..
Mosquito   326 DYLHTKCKIIHTDIKPENVLVCVNESYVRKLACEATEMHAMGCKLPISLISAAPPQFQEQPMSQN 390

  Fly   356 MSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVH 420
            |||.:|||||:|||.:.||.:||.::::|.:....:..:...:|..|
Mosquito   391 MSKAKKKKLKRKAKMQHELIRQQMEHIQQLEFGAPVAVDGASSGSGG------------------ 437

  Fly   421 VAAGQPSRKQREERKAPPEQSEEAQEQDPL----TEGTDKAKKKKKKKNKNKSNQSKGQQPPQ-- 479
            .|||.|...         ..:|..:...||    .||........|......||.:.|...|.
Mosquito   438 PAAGLPLEN---------GTAEGMESGKPLLALAAEGAGGGGATLKGVTTAGSNTAAGTGTPNSP 493

  Fly   480 LENSTSSAESSSALKSQQANGSNSTTNN--------KSNTNSSG-----TLKGQSNGKKMPLRPK 531
            ||...:..|:...|    .||:...|..        ::.|.|||     ||...::....|...:
Mosquito   494 LERKEAGGEARRLL----VNGTAEATTTAGGKECVAEAGTPSSGDEDRPTLTPSASTLSSPSSSE 554

  Fly   532 QEKQGSNHQLNNNNSKP-------------NSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPP 583
            .....:|..:..:...|             ::.|..|.||.|:..:||..:...|...:
Mosquito   555 AASSNNNDDVPGDRKSPTARVHDGDERRERDAKSPEKPSSSSLVTSSSKLDISESVRKI------ 613

  Fly   584 PQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTA 648
             .:..:..||.|.:.|::.|||||||||||||:||||||||||||||||||||||:|||||||||
Mosquito   614 -LSSVQESKDAAFEVCDIDVKIADLGNACWVDKHFTEDIQTRQYRSLEVIIGAGYDTSADIWSTA 677

  Fly   649 CMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGL 713
            ||.||||||||||||.||:.|.||:||:|||||||||||:.|.|:|..::.:|.....|:|||||
Mosquito   678 CMAFELATGDYLFEPFSGKDYCRDDDHIAHIIELLGPIPKRIALSGKNSSHAFNSKGLLKNISGL 742

  Fly   714 KPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            |||||:|||:||||||.:||..|:.||.|||::||..|||||:||:|.||
Mosquito   743 KPWGLVDVLIEKYEWSDEDAFEFSDFLKPMLDYDPRTRATAADCLRHSWL 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	122/158 (77%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	118/162 (73%)
SRPK	XP_061498458.1	None