Protein Alignment SRPK and srpk2

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: XP_031753411.1
• Gene: srpk2 / 100125041
• XenbaseID: XB-GENE-990797
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 847
• Identity: 344/847 - (40%)
• Similarity: 463/847 - (54%)
• Gaps: 192/847 - (22%)

  Fly     9 RVLAIQAKKKRHKNRK-RGKQNGTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSH 72
            :||||||:|:|.|.:| :.::......|:                 |||
 Frog     5 KVLAIQARKRRPKGKKEKARKKKIEADER-----------------EPN---------------- 36

  Fly    73 LNAPSSAAFSKATATATASTSSGGSAGTPDQYQPPKKTQAKAK-PNTQKEHQQQP--PRSSSNES 134
                                       ||:.|:...:.:|:.| |:........|  |..|..|:
 Frog    37 ---------------------------TPEGYEKDSRPEAQQKVPSAPPPPPPPPPLPEPSPPEA 74

  Fly   135 YESETFSDNEDQELMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIK 199
            .|....||:|:||...||||||||||.|||||:.|||||||||||||||||||||:|...:||:|
 Frog    75 EEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMK 139

  Fly   200 IVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLK 264
            :||||.|:.|||.||||:|:.|||:||.:|.:...||::|||||:|:||.|:||||||||.:|||
 Frog   140 VVKSAQHYTETALDEIKLLRCVRESDPRDPNKDMVVQLIDDFKISGMNGMHVCMVFEVLGHHLLK 204

  Fly   265 LIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLY 329
            .|.||||:|:|:..||:|.||||:||||||:.||||||||||||:|:||::.:||.:|.|||:
 Frog   205 WIIKSNYQGLPIRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVEDAYVRRMAAEATE-- 267

  Fly   330 CMNSKMYP---SLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAI 391
            ...:...|   |.||.||   ::.|| ||:|||:|||||||.|::.||.:::...:|:.:.:.
 Frog   268 WQKAGAPPPSGSAVSTAP---QQKPI-GKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREA-- 326

  Fly   392 NPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTE---G 453
               |.:..:..:|        :::..|.....|.|      |.|......|:|.:::|:.|   |
 Frog   327 ---ERKKAEETVS--------STILLNEQDLEGHP------EAKMKSVCLEDAADEEPVNEYERG 374

  Fly   454 TDKAKKKKKKKNKNKSNQSKG----------------QQP--------------PQLENSTSSAE 488
            .:..|:..:|:|..|.::.:.                :.|              ||||:...  |
 Frog   375 DNDEKEDTEKENIEKDDEDEDDDDAEPELVDTDQTWIESPKTNGHLENGPFSVEPQLEDEED--E 437

  Fly   489 SSSALKSQQANGSNSTTNNKSNTNSSGTLKG---QSNGKKMPLRPKQEKQGSNHQLNNNNSK--P 548
            ....|..::.|      .::||..|..|...   |.||:    .|..:.:.|..|.:..::.  |
 Frog   438 DDDCLNPEEFN------LDESNVESDYTYSSSYEQFNGE----LPNGQHKNSELQFSEFSASVFP 492

  Fly   549 NS----------NSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKK---DPALDECN 600
            .:          :.||.::..  :.:||..:...:.|...|...|..:|.:|..   :| ||..|
 Frog   493 EALESAACGLAISEDSALTDR--DESSSCHDRSRTVSASSTGDLPKTSKMRAADLLVNP-LDPRN 554

  Fly   601 ---VHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFE 662
               :.||||||||||||.:|||||||||||||:||:|||||:|.|||||||||.|||||||||||
 Frog   555 ADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFE 619

  Fly   663 PHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAK---------------------------- 699
            |||||.|:|||||:||||||||.|||...|:|.|:.:
 Frog   620 PHSGEDYSRDEDHIAHIIELLGNIPRHFALSGKYSREFFNRRDHIALITELLGKIPRKFAMLGKY 684

  Fly   700 ---SFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHP 761
               .||:..|||:|:.||||.|.|||:|||.|.|:|||.|..|||||||..|.|||:|.|||:||
 Frog   685 SKDFFTKKGELRHITKLKPWSLFDVLVEKYGWPQEDAAQFTDFLTPMLEMVPEKRASAGECLRHP 749

  Fly   762 WL 763
            ||
 Frog   750 WL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	108/158 (68%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	119/196 (61%)
srpk2	XP_031753411.1	Protein Kinases, catalytic domain	97..>285	CDD:473864	120/189 (63%)
		Protein Kinases, catalytic domain	<542..751	CDD:473864	123/209 (59%)