Protein Alignment SRPK and srpk3

DIOPT Version :10

• Sequence 1: NP_001369087.1
• Gene: SRPK / 36706
• FlyBaseID: FBgn0286813
• Length: 1009
• Species: Drosophila melanogaster
• Sequence 2: NP_001096257.1
• Gene: srpk3 / 100124819
• XenbaseID: XB-GENE-1010990
• Length: 637
• Species: Xenopus tropicalis
• Alignment Length: 765
• Identity: 333/765 - (43%)
• Similarity: 415/765 - (54%)
• Gaps: 152/765 - (19%)

  Fly    18 KRHKNRKRGKQNGTNPQEQSNSSQNQNPKPSSNPIPEPNRSSENLQAPDNANNSHLNAPSSAAFS 82
            |:.....:||::....:.|..:::...|     .:|||...|.:.| |....:|..:.|.|..
 Frog     4 KKVSGNSQGKKSKKKQRRQRKAAERDVP-----GVPEPRSPSLDSQ-PGLPEHSLQDVPLSPG-- 60

  Fly    83 KATATATASTSSGGSAGTPDQYQPPKKTQAKAKPNTQKEHQQQPPRSSSNESYESETFSDNEDQE 147
                                   ||........|         ||         ....||||:||
 Frog    61 -----------------------PPPTPPTPVLP---------PP---------GPLGSDNEEQE 84

  Fly   148 LMEDYCKGGYHPVNIGDLFHDRYHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETAR 212
            ...|||:|||:||.|||||:.||||:||||||||||||||||||...:||:|:||||.|:.|||.
 Frog    85 DPGDYCRGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDLQRKRFVALKVVKSAVHYTETAL 149

  Fly   213 DEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKSNYRGIPLA 277
            ||||:||.||::|||:.:|...||::|||||:||||.|||||.||||..|||.|.||||.|:||.
 Frog   150 DEIKLLKCVRDSDPSDSKREMIVQLIDDFKISGVNGVHICMVLEVLGHQLLKWIIKSNYEGVPLP 214

  Fly   278 NVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYP---SL 339
            .||:|.||||:|||||||.||||||||||||:|:||:|.::|.||.|||  ....|.|.|   |.
 Frog   215 CVKSILRQVLQGLDYLHTKCKIIHTDIKPENILMCVEEGYIRRLAAEAT--IWQQSGMPPPSGSA 277

  Fly   340 VSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGIS 404
            ||.||..::.  :.||:|||:|||||::.|::.:|.
 Frog   278 VSSAPPSHQN--LNGKVSKNKKKKLKRQQKRQQKLL----------------------------- 311

  Fly   405 DADEYFDANSVEDNVHVAAGQPSRKQREERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKS 469
                                       |||.......||       ..|.|.....:...|....
 Frog   312 ---------------------------EERLRDIHNMEE-------LGGGDSCPNIQHHCNPGNH 342

  Fly   470 NQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEK 534
            .|..|||..| |.:..| ||:|.|.|   |..:|||.::...:||....|.:...:.|......|
 Frog   343 EQHWGQQSSQ-ETAVKS-ESTSQLIS---NPISSTTGDQECADSSLGSGGTTCLAQSPQSTGLYK 402

  Fly   535 QGSNHQLNNNNSKPNSNSDSKISSGSVENTS----SATNGPHSNSTLPTP------------PPP 583
            ..:.:......|.|:::: |..||.::..||    |..:|......:.:|            |..
 Frog   403 SCNGYSSGTRGSSPDTHT-SGFSSSALSATSGSAISGYSGVRGRGGILSPNLLFCAADFLVNPLD 466

  Fly   584 PQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTA 648
            ||...|           :.||||||||||||.:||||||||||||:|||:|||||.|.|||||||
 Frog   467 PQNADK-----------IQVKIADLGNACWVHKHFTEDIQTRQYRALEVLIGAGYGTPADIWSTA 520

  Fly   649 CMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGL 713
            ||.||||||||||||||||.|||||||:||||||||.||....|:|.|:.:.|:|..|||:|..|
 Frog   521 CMAFELATGDYLFEPHSGEDYTRDEDHIAHIIELLGDIPPHFALSGRYSREYFSRRGELRHIQNL 585

  Fly   714 KPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL 763
            |.|||.|||:||||||.::|..|..||.|||||.|.|||||::|||||||
 Frog   586 KHWGLFDVLVEKYEWSLEEATQFTDFLMPMLEFLPEKRATASQCLQHPWL 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRPK	NP_001369087.1	Protein Kinases, catalytic domain	159..>318	CDD:473864	113/158 (72%)
		Protein Kinases, catalytic domain	<600..763	CDD:473864	118/162 (73%)
srpk3	NP_001096257.1	STKc_SRPK3	96..635	CDD:271120	300/622 (48%)