DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and MLH3

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_015161.1	Gene:	MLH3 / 855939	SGDID:	S000006085	Length:	715	Species:	Saccharomyces cerevisiae

Alignment Length:	961	Identity:	199/961 - (20%)
Similarity:	331/961 - (34%)	Gaps:	359/961 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            :|..|:.:..|...::.|....:|||.||:|:|:||:||.||.:::.:....| |..|.|:|.|:
Yeast     1 MSQHIRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTIDVMIDLPNL-SFAVYDDGIGL 64

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHE 152
            ...:|..:..:.:|||||:..||:.::|:|:||:||.|:..:|::.:.::.|          |:.
Yeast    65 TRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYSISNVSNLFVCSKKK----------DYN 119

  Fly   153 GRIKKRSPCARGV------------------------GTTVLLANLFSTLPVRRRDFTRNIKKE- 192
            ....::.| ::.|                        ||.|::.::...||||||     |.||
Yeast   120 SAWMRKFP-SKSVMLSENTILPIDPFWKICPWSRTKSGTVVIVEDMLYNLPVRRR-----ILKEE 178

  Fly   193 ---------FTKMCQILQAYCLVTKGVRILCSNHTPK---------GAKTIVLQTHGDQEVMANI 239
                     ...|.|||..:.:::..|:     :|.|         .:|.|.......|::...:
Yeast   179 PPFKTFNTIKADMLQILVMHPMISLNVQ-----YTDKLRINTEVLFRSKNITEGLTKHQQMSQVL 238

  Fly   240 SAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSPQISTEDVERLNQADFQLEGF 304
            ..:|||     ::|                      .|:....|          |...::|:||.
Yeast   239 RNVFGA-----IIP----------------------PDMLKKVS----------LKFNEYQIEGI 266

  Fly   305 ISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLT 369
            ||....|.    :|.||.::|.|                ||              |.|...
Yeast   267 ISKMPVGL----KDLQFIYINGR----------------RY--------------ADSAFQ---- 293

  Fly   370 PDKRQLLINNERILLLALKKSLLDTFGQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQH 434
                                      |...:.||.|:.....|...||        |...|..:.
Yeast   294 --------------------------GYVDSLFQAQDFGEKGMSLLKT--------KSVGKPYRS 324

  Fly   435 EEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVKRRCSES-----EELVTRTLKMQKIHT 494
            ..|...||....|   :|.|.|             .|.|:....|     |.|:.:|::  ...|
Yeast   325 HPVFILDVRCPQT---IDDLLQ-------------DPAKKIVKPSHIRTIEPLIVKTIR--SFLT 371

  Fly   495 FLSQESPNEQSSKCEAESDAASDVDMAKKDKT------QVSLDNSFLNLKELAKESEAYDLLTKP 553
            |....:|::..|..|.       |:.::|..|      |:|..|..||.|.......:|  :.||
Yeast   372 FQGYLTPDKSDSSFEI-------VNCSQKTATLPDSRIQISKRNQVLNSKMKIARINSY--IGKP 427

  Fly   554 Q-NTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQESPA--ELNSQP--PSFTQLSEETDIASDED 613
            . |..||:...:.        :| |...:.:|.|:|..  :|:|:|  ..||:
Yeast   428 AVNGCRINNSTIN--------YE-KIKNIRIDGQKSRLRNKLSSRPYDSGFTE------------ 471

  Fly   614 DHIELPTRIEFDEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEIN 678
                     ::|           |.|:..|..
Yeast   472 ---------DYD-----------SIGKTITDF--------------------------------- 483

  Fly   679 PNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDD-------LFIVDQHATDEKYNFET 736
                         .|.:...|:.|:|.|.:..||:::..|.       |.:|||||.||:...|
Yeast   484 -------------SISRSVLAKYEVINQVDKKFILIRCLDQSIHNCPLLVLVDQHACDERIRLE- 534

  Fly   737 LQRTTQLEYQRLA-------VPQNLELTAV----NEMVLLNHI-DVFEKNGFKFEVDHEAPATKK 789
                 :|.|..|.       |.::|:...:    .|..|..|. ..|:|.|..:|.......|..
Yeast   535 -----ELFYSLLTEVVTGTFVARDLKDCCIEVDRTEADLFKHYQSEFKKWGIGYETIEGTMETSL 594

  Fly   790 VRLLGKPHSKRWEF-GKEDIDELIFMLQDAPE---------------------------GTICRP 826
            :.:...|.....:: |.:|..::: :||.|.:                           .:.|.|
Yeast   595 LEIKTLPEMLTSKYNGDKDYLKMV-LLQHAHDLKDFKKLPMDLSHFENYTSVDKLYWWKYSSCVP 658

  Fly   827 SRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTM 877
            :....:..|:|||.:||.|..|:|...: .||:::.....|:.|.||||:|
Yeast   659 TVFHEILNSKACRSAVMFGDELTRQECI-ILISKLSRCHNPFECAHGRPSM 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	198/958 (21%)
		HATPase_c	46..>151	CDD:294057	36/104 (35%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	22/142 (15%)
		MutL_C	703..847	CDD:214857	42/190 (22%)
MLH3	NP_015161.1	MutL	1..715	CDD:223400	199/961 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810