Protein Alignment Pms2 and PMS1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_014317.4
• Gene: PMS1 / 855642
• SGDID: S000005026
• Length: 873
• Species: Saccharomyces cerevisiae
• Alignment Length: 970
• Identity: 308/970 - (31%)
• Similarity: 472/970 - (48%)
• Gaps: 223/970 - (22%)

  Fly    26 QIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEM 90
            ||..|....||:|.||||:..|..||||||:|||||.|..:||..||.||:|:|.||||.|::..
Yeast     3 QIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIEIIFKDYGLESIECSDNGDGIDPS 67

  Fly    91 NLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRI 155
            |.|.:..|::||||.:|.|:..|:|.|||||||||||.::.:.:.|. .|.....|:|.|..|.|
Yeast    68 NYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITT-TSPPKADKLEYDMVGHI 131

  Fly   156 KKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHTPK 220
            ..::..:|..|||||::.||..||||:::|::..|::|||...::|.|.::...::....|.|||
Yeast   132 TSKTTTSRNKGTTVLVSQLFHNLPVRQKEFSKTFKRQFTKCLTVIQGYAIINAAIKFSVWNITPK 196

  Fly   221 GAKTIVLQTHGDQEVMANISAIFGA-----RQAADLVPLKSPFGQGQLTEAELRADLESGADLAD 280
            |.|.::|.|..:..:..|||::|||     .:..|||...:||....|.:
Yeast   197 GKKNLILSTMRNSSMRKNISSVFGAGGMRGLEEVDLVLDLNPFKNRMLGK--------------- 246

  Fly   281 TTSPQISTEDVERLNQADFQL--EGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYH 343
                  .|:|.:.|: .|:::  :|:||....|.||:|:||||.:||.||.:...:.|..||||.
Yeast   247 ------YTDDPDFLD-LDYKIRVKGYISQNSFGCGRNSKDRQFIYVNKRPVEYSTLLKCCNEVYK 304

  Fly   344 RYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQMQNTT 408
            .:|..|.|.::||:....|.:|||:|||||.:|::|||.::...|.:|.|.:.:
Yeast   305 TFNNVQFPAVFLNLELPMSLIDVNVTPDKRVILLHNERAVIDIFKTTLSDYYNR----------- 358

  Fly   409 IVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVK 473
                                         .|..:|                             |
Yeast   359 -----------------------------QELALP-----------------------------K 365

  Fly   474 RRCSESEELVTRTLKMQKI-HTFLSQESPNEQSSKCEAESDAASDVD-------MAKKDKTQVS- 529
            |.||:||:...:.||.:.. ....:.||.||......:||:.::...       :.|.:.|:::
Yeast   366 RMCSQSEQQAQKRLKTEVFDDRSTTHESDNENYHTARSESNQSNHAHFNSTTGVIDKSNGTELTS 430

  Fly   530 -LDNSFLNLKE-LAKESEAYDLLTKPQNTPRIDCKVL-------TPIKSRRSIFEFKTDAMAL-- 583
             :|.::.|:.: :..|.|.           .:|..|:       ||.|...||   |||:..|
Yeast   431 VMDGNYTNVTDVIGSECEV-----------SVDSSVVLDEGNSSTPTKKLPSI---KTDSQNLSD 481

  Fly   584 -----------------DKQESPAELNSQPPSF-------------------------------- 599
                             ||..|..::..:|..|
Yeast   482 LNLNNFSNPEFQNITSPDKARSLEKVVEEPVYFDIDGEKFQEKAVLSQADGLVFVDNECHEHTND 546

  Fly   600 -----------TQLSEETDIASDEDDHIELPTR---------IEFD--EEMEEGLPSNFSSGEI- 641
                       |:..:|.|....|.:.:|:..|         |..|  ..:.:||.......||
Yeast   547 CCHQERRGSTDTEQDDEADSIYAEIEPVEINVRTPLKNSRKSISKDNYRSLSDGLTHRKFEDEIL 611

  Fly   642 -----TTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARM 701
                 |.:.:||:.:.|........|::..:...::.|.|:...:  ..|..|...:.|.||.:|
Yeast   612 EYNLSTKNFKEISKNGKQMSSIISKRKSEAQENIIKNKDELEDFE--QGEKYLTLTVSKNDFKKM 674

  Fly   702 EIIGQFNLGFIIV--KLED--DLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEM 762
            |::||||||||||  |:::  |||||||||:||||||||||..|..:.|:|.:||.:||:.::|:
Yeast   675 EVVGQFNLGFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVFKSQKLIIPQPVELSVIDEL 739

  Fly   763 VLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTI---- 823
            |:|:::.||||||||.::|.|.....:|:||..|.||:..|...|.:|||.::::  :|.:
Yeast   740 VVLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKE--DGGLRRDN 802

  Fly   824 CRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLINI 883
            .|.|::|:|||.||||.|:|||..|::. ||.|::..:.|:::||||||||||||||:.:
Yeast   803 IRCSKIRSMFAMRACRSSIMIGKPLNKK-TMTRVVHNLSELDKPWNCPHGRPTMRHLMEL 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	306/965 (32%)
		HATPase_c	46..>151	CDD:294057	52/104 (50%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	52/149 (35%)
		MutL_C	703..847	CDD:214857	76/151 (50%)
PMS1	NP_014317.4	MutL	1..870	CDD:223400	308/970 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346584
Domainoid	1	1.000	143	1.000	Domainoid score	I1001
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I261
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53578
OrthoFinder	1	1.000	-	-		FOG0003329
OrthoInspector	1	1.000	-	-		oto100291
orthoMCL	1	0.900	-	-		OOG6_101943
Panther	1	1.100	-	-	LDO	PTHR10073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R938
SonicParanoid	1	1.000	-	-		X2695
TreeFam	1	0.960	-	-
	13	12.790