Protein Alignment Pms2 and MLH1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_013890.1
• Gene: MLH1 / 855203
• SGDID: S000004777
• Length: 769
• Species: Saccharomyces cerevisiae
• Alignment Length: 810
• Identity: 177/810 - (21%)
• Similarity: 335/810 - (41%)
• Gaps: 218/810 - (26%)

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            :|.:|||:....|:||.:|::::|...|:||::||||||.||:::|.:|:.|::.::::|||||:
Yeast     1 MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGI 65

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHE 152
            .:.:|..:..::.|||:::|.||..::|:|||||||:|:..::.:.:.|:.|......:|.....
Yeast    66 NKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEG 130

  Fly   153 GRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNH 217
            ..::...|.|...|||:|:.:||..:|.|.|.. |:...|::|:..::..|.:.:|.:...|...
Yeast   131 KMLESPKPVAGKDGTTILVEDLFFNIPSRLRAL-RSHNDEYSKILDVVGRYAIHSKDIGFSCKKF 194

  Fly   218 TPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTT 282
               |.....|.......|...|..:|....|::|:..       .:::.|
Yeast   195 ---GDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITF-------HISKVE--------------- 234

  Fly   283 SPQISTEDVE----RLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSR--PCDPKNIAKVMNEV 341
              .::.|.|:    .||        |||        .......||:|:|  .||  .:.:.:|.|
Yeast   235 --DLNLESVDGKVCNLN--------FIS--------KKSISPIFFINNRLVTCD--LLRRALNSV 279

  Fly   342 YHRYNVQ-QQPFIYLNIITARSDVDVNLTPDKRQL-LINNERIL-----LLALKKSLLDTFGQTP 399
            |..|..: .:|||||.|:...:.||||:.|.||:: .::.:.|:     .|..:.|.:|    |.
Yeast   280 YSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAELSAID----TS 340

  Fly   400 ATFQMQNTTIVSMLEPKTNSGKTKFP-KESSKDDQHE------EVSEEDVPTTSTQRFMDVLTQW 457
            .||:..:.:        ||..::..| .::.:.|::.      :|.|....|.::|
Yeast   341 RTFKASSIS--------TNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQ--------- 388

  Fly   458 RRTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAK 522
                          :::...:..:||.......||.:|||    :.|....|..|        .|
Yeast   389 --------------LRKAKRQENKLVRIDASQAKITSFLS----SSQQFNFEGSS--------TK 427

  Fly   523 KDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLT-------PIKSRRSIFEFKTDA 580
            :..::..:.|       ::...||..|.......|| |...:.       | |.::.:.::|..:
Yeast   428 RQLSEPKVTN-------VSHSQEAEKLTLNESEQPR-DANTINDNDLKDQP-KKKQKLGDYKVPS 483

  Fly   581 MALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTSL 645
            :|.|      |.|:.|.|             :|.:|.:|
Yeast   484 IADD------EKNALPIS-------------KDGYIRVP-------------------------- 503

  Fly   646 EEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLG 710
                        ::|.....|.:::||.|          .:..:.||: .:.||.:..:|..:..
Yeast   504 ------------KERVNVNLTSIKKLREK----------VDDSIHREL-TDIFANLNYVGVVDEE 545

  Fly   711 FIIVKLEDD--LFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAV-NEMVLLNHIDVFE 772
            ..:..::.|  ||::|..:...:. |..:..|....:.::    ||:.|.| :::||.|.:..|:
Yeast   546 RRLAAIQHDLKLFLIDYGSVCYEL-FYQIGLTDFANFGKI----NLQSTNVSDDIVLYNLLSEFD 605

  Fly   773 KNGFKFEVDHEAPATKKVRLLGKPHSKRWE 802
                  |::.:|...|.:       ||.|:
Yeast   606 ------ELNDDASKEKII-------SKIWD 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	176/807 (22%)
		HATPase_c	46..>151	CDD:294057	39/104 (38%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	35/150 (23%)
		MutL_C	703..847	CDD:214857	21/103 (20%)
MLH1	NP_013890.1	MutL	1..744	CDD:223400	177/810 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810