DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and MLH2

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_013135.1	Gene:	MLH2 / 850722	SGDID:	S000004025	Length:	695	Species:	Saccharomyces cerevisiae

Alignment Length:	763	Identity:	167/763 - (21%)
Similarity:	294/763 - (38%)	Gaps:	212/763 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TVH--------KICSGQVVLSLAVAVKELVENSIDAGA--TLVEIKLKDQGLQSVEVSDNGSGVE 88
            |:|        ||.|...:.....||:||::||||:||  ..:::.....|.:.:.|.|:||||:
Yeast     2 TIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVD 66

  Fly    89 EMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEA---LSSLC-ALSDMVIQTRHKSTDVGVKVEL 149
            .::...|..:|.|||:....|:..:.|.||||||   ||:|| ....|.::|:.....:|.|..:
Yeast    67 IIDRPSMCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLV 131

  Fly   150 DHEGRIK--KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRI 212
            |.:|.|.  ||...:..|||||:|..|...|..|..:.:...:|.|.::..::..|.|:.:.:|.
Yeast   132 DSKGGITNGKRYKVSCPVGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLIHRNIRF 196

  Fly   213 LCSNHTPKGAKTIVLQTHGD------QEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRAD 271
            ..|        .:.||.:|.      ||.:.  ..|..||..:.|..||.|.....:.|.....|
Yeast   197 YFS--------LVSLQKNGAIERKQMQETLD--PKISRARSLSLLARLKKPVPLNFIVEENFVID 251

  Fly   272 LESGADLADTTSPQISTE-DVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCD----- 330
            .:...||   ..|::..| ||..:                     .|..:|..||.|...
Yeast   252 EKINLDL---ILPRMVPESDVINI---------------------KRRFKFLSVNERALSLNLET 292

  Fly   331 PKNIAKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLI-----------NNERILL 384
            .|.|:|:::.:|..:::......::|:......:|||:.|:|..::|           |..::||
Yeast   293 GKTISKLLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIENKLKLLL 357

  Fly   385 ---LALKKSLL-DTFGQ-------TPA-------------------------------------T 401
               :.::.::| |...|       :||                                     |
Yeast   358 EERIGIETNMLGDKHVQPSINEKTSPALVIPTPDAENEISKGCGAVSGKDKTDIPQKNSDLIVPT 422

  Fly   402 F----QMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGD 462
            |    .::|||||:     .....|||.::.:.|:|.:........::|.....:..|.||..
Yeast   423 FYDEANLENTTIVA-----ATPSPTKFSEDKALDEQTQLTISSYRSSSSGSMASEDSTNWRHN-- 480

  Fly   463 TKGTAPSVPVKRRCSESEELV---TRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAKKD 524
                     .::..||:.|:.   :.||.....:.::.....||             |::::|
Yeast   481 ---------FQQELSENSEVAGAGSSTLPSSLTYNYIETIPENE-------------DLELSK-- 521

  Fly   525 KTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFEFK-TDAMALDKQES 588
              ..|:.|.|              ::||.:|..:         |...::.|.| |.....:|:..
Yeast   522 --DASISNPF--------------MITKIRNVNK---------KLSENLLEAKRTSCGDANKRGM 561

  Fly   589 PAELNSQPPSFTQLSEETDIASDEDDHIEL-PTRIEFDEEMEEGLPSNFSSGEITTSLEEIASSL 652
            |.|        .|||.     :::.:.|:| .|..:.:..::..:|.| |..::|.:..:.||.:
Yeast   562 PNE--------RQLSN-----TEKKELIKLQQTYGKRNNTVDMTIPRN-SKKKVTDNYIKKASCM 612

  Fly   653 KAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFAR 700
                     .:||.||...   :|...|...:.:.|...:.|.::||:
Yeast   613 ---------HKTRPKLMHF---SEYTNNYVYTLKNEKIVKHDSDNFAK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	167/763 (22%)
		HATPase_c	46..>151	CDD:294057	38/110 (35%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	32/159 (20%)
		MutL_C	703..847	CDD:214857
MLH2	NP_013135.1	MutL	2..693	CDD:223400	167/763 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R938
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940