Protein Alignment Pms2 and MLH3

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001328252.1
• Gene: MLH3 / 829704
• AraportID: AT4G35520
• Length: 1180
• Species: Arabidopsis thaliana
• Alignment Length: 1244
• Identity: 251/1244 - (20%)
• Similarity: 403/1244 - (32%)
• Gaps: 486/1244 - (39%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQ--SVEVSDNGSGVEE 89
            ||.:.:...|.:.||.::..:|..|:|||.||:|||||.|.|.:   |:.  ||:|.|:||||..
plant     4 IKPLPEGVRHSMRSGIIMFDMARVVEELVFNSLDAGATKVSIFV---GVVSCSVKVVDDGSGVSR 65

  Fly    90 MNLEGMTAKYHTSKIREFVDL-LGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEG 153
            .:|..:..:|.|||..:|.:: ...||||||||||:|:..:|.:.::|:......|.:
plant    66 DDLVLLGERYATSKFHDFTNVETASETFGFRGEALASISDISLLEVRTKAIGRPNGYR------- 123

  Fly   154 RIKKRSPCAR-GV-------GTTVLLANLFSTLPVRRRDFTRNIKK--EFTKMCQILQAYCLVTK 208
            ::.|.|.|.. |:       ||||.:.:||.:.||||:....:.||  |..|.|....|.
plant   124 KVMKGSKCLHLGIDDDRKDSGTTVTVRDLFYSQPVRRKYMQSSPKKVLESIKKCVFRIAL----- 183

  Fly   209 GVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLE 273
                                      |.:|:|  |..                        .|:|
plant   184 --------------------------VHSNVS--FSV------------------------LDIE 196

  Fly   274 SGADLADTTSPQIS----------TEDVE---RLNQAD--FQLEGFISSCRHGAGRSSRDRQFFF 323
            |..:|.. |:|..|          ||.|.   ::|..|  ..:.|::|    |.|.|.:..|:.:
plant   197 SDEELFQ-TNPSSSAFSLLMRDAGTEAVNSLCKVNVTDGMLNVSGYVS----GPGDSLKALQYIY 256

  Fly   324 VNSRPCDPKNIAKVMN------------------EVYHRYNVQQQPFIYLNIITARSDVDVNLTP 370
            :|||......|.|::|                  :...|..:|..|...|.|...|...:.:..|
plant   257 INSRFISKGPIHKLLNNLATSFECADDWKPTDGQQTGRRNRLQSNPGYILCIACPRRLYEFSFEP 321

  Fly   371 DKRQ--------LLINNERILLLALKKS-LLDTF----------------------------GQT 398
            .|..        :|...|||.|...||. :|:.|                            ...
plant   322 SKTHVEFKKWGPVLAFIERITLANWKKDRILELFDGGADILAKGDRQDLIDDKIRLQNDWPEAME 386

  Fly   399 PATFQMQNTT----IVSMLEPKTN---SG------------------KTKFPKE-------SSKD 431
            ||..:::.:.    ..|:|.|..:   .|                  |.:.|||       .|:.
plant   387 PAKKKLKRSNDHAPCSSLLFPSADFKQDGDYFSPRKDVWSPECEVELKIQNPKEQGTVAGFESRT 451

  Fly   432 D---QHEEV---SEEDVPTTS-----------------------------TQRFM---DVLT-QW 457
            |   |..::   :.||.|..:                             ...||   |||. |:
plant   452 DSLLQSRDIEMQTNEDFPQVTDLLETSLVADSKCRKQFLTRCQITTPVNINHDFMKDSDVLNFQF 516

  Fly   458 RRTGDTKGTAPSV--PVKRRCSESEELVTRTLKMQKIHTFLS---------QESP-----NEQSS 506
            :...|....:..:  .:.|.||....|.....|:..:..:.|         |.||     .|..|
plant   517 QGLKDELDVSNCIGKHLLRGCSSRVSLTFHEPKLSHVEGYESVVPMIPNEKQSSPRVLETREGGS 581

  Fly   507 KCEAESDAASDVDM-------------AKKDKTQVSLDNSFLNLKEL-AKESEAYD--------- 548
            .|:..||...|..:             ...|:..|.:...| |:..: ..|.::||
plant   582 YCDVYSDKTPDCSLGSSWQDTDWFTPQCSSDRGCVGIGEDF-NITPIDTAEFDSYDEKVGSKKYL 645

  Fly   549 ---------------------LLTKPQNT------------------------------------ 556
                                 :.:.|..|
plant   646 SSVNVGSSVTGSFCLSSEWSPMYSTPSATKWESEYQKGCRILEQSLRLGRMPDPEFCFSAANNIK 710

  Fly   557 ------PRIDC-----KVLTPIKS--------------------------RRSIFEF-------- 576
                  |.:||     ...|.|::                          |:..|.:
plant   711 FDHEVIPEMDCCETGTDSFTAIQNCTQLADKICKSSWGHADDVRIDQYSIRKEKFSYMDGTQNNA 775

  Fly   577 --------------------------KTDAMALDKQESPAELN-----SQPPSFTQLSEETDIAS 610
                                      |:|..  .|...|:|.:     :||.:.:|:..:..|..
plant   776 GKQRSKRSRSAPPFYREKKRFISLSCKSDTK--PKNSDPSEPDDLECLTQPCNASQMHLKCSILD 838

  Fly   611 DED-DHIE---------------LPTRIEFDEEMEEGLPSNFSSGEITTSLEEIASSLK------ 653
            |.. |||:               ...|....|..:|.:..:|||.|.   |:.|.|:.|
plant   839 DVSYDHIQETEKRLSSASDLKASAGCRTVHSETQDEDVHEDFSSEEF---LDPIKSTTKWRHNCA 900

  Fly   654 -------AHEQQQRDR--RTRTKLQRLRFKTEINP---NQNTSAEAELQREIDKEDFARMEIIGQ 706
                   :||...:|.  ...:.|..||....:.|   |:::..:|::.:::||:
plant   901 VSQVPKESHELHGQDGVFDISSGLLHLRSDESLVPESINRHSLEDAKVLQQVDKK---------- 955

  Fly   707 FNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQR-----LAVPQNLELTAVNEMVLLN 766
                :|.:.....:.||||||.||:...|.| ||..|..:.     |:..|.|.|..:...:|.:
plant   956 ----YIPIVACGTVAIVDQHAADERIRLEEL-RTKVLAGKARTVTYLSADQELVLPEMGYQLLQS 1015

  Fly   767 HIDVFEKNGFKFEVDHEAPATKKVR------------------LLGKPHSKRWEFGKEDIDELIF 813
            :.:.....|:...:..|...:.|..                  :||        ....|:|.|.|
plant  1016 YSEQIRDWGWICNITVEGSTSFKKNMSIIQRKPTPITLNAVPCILG--------VNLSDVDLLEF 1072

  Fly   814 MLQDA-PEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTM 877
            :.|.| .:|:...|..|..:..|:|||.::|.|.:| ..:....:|..:.:....:.|.|||||.
plant  1073 LQQLADTDGSSTIPPSVLRVLNSKACRGAIMFGDSL-LPSECSLIIDGLKQTSLCFQCAHGRPTT 1136

  Fly   878 RHLINIAML 886
            ..|:::..|
plant  1137 VPLVDLKAL 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	104/402 (26%)
		mutL	33..880	CDD:234630	247/1230 (20%)
MLH3	NP_001328252.1	mutl	2..273	CDD:273155	95/340 (28%)
		TopoII_MutL_Trans	209..339	CDD:445919	27/133 (20%)
		MutL_C	948..1106	CDD:214857	40/180 (22%)