Protein Alignment Pms2 and PMS1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_567236.1
• Gene: PMS1 / 827997
• AraportID: AT4G02460
• Length: 923
• Species: Arabidopsis thaliana
• Alignment Length: 1003
• Identity: 330/1003 - (32%)
• Similarity: 499/1003 - (49%)
• Gaps: 217/1003 - (21%)

  Fly    17 PPPTTALSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVS 81
            |.|||..|..|:.|.::.:|:||||||:|.|:.|||||||||:|||||.:||.|:|.|....:|.
plant     7 PSPTTTSSPLIRPINRNVIHRICSGQVILDLSSAVKELVENSLDAGATSIEINLRDYGEDYFQVI 71

  Fly    82 DNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVK 146
            |||.|:...|.:.:..|:||||:.:|.|||.:.|:|||||||||||||.::.::||.|:..|...
plant    72 DNGCGISPTNFKVLALKHHTSKLEDFTDLLNLTTYGFRGEALSSLCALGNLTVETRTKNEPVATL 136

  Fly   147 VELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVR 211
            :..||.|.:......||.:||||.:..|||.||||.::|.|||:||:.|:..:|.||.|:.||||
plant   137 LTFDHSGLLTAEKKTARQIGTTVTVRKLFSNLPVRSKEFKRNIRKEYGKLVSLLNAYALIAKGVR 201

  Fly   212 ILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGA 276
            .:|||.|.|..|::||.|.|...:..||..:||......|.|:.....:
plant   202 FVCSNTTGKNPKSVVLNTQGRGSLKDNIITVFGISTFTSLQPVSICVSE---------------- 250

  Fly   277 DLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEV 341
                                 |.::|||:|....|.||:..|||:||:|.||.|...::|::||:
plant   251 ---------------------DCRVEGFLSKPGQGTGRNLADRQYFFINGRPVDMPKVSKLVNEL 294

  Fly   342 YHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATF---- 402
            |...:.::.|...|:.|......|:|:|||||::..::|..::.:|::.|.:.:..:.|::
plant   295 YKDTSSRKYPVTILDFIVPGGACDLNVTPDKRKVFFSDETSVIGSLREGLNEIYSSSNASYIVNR 359

  Fly   403 -----QMQNTTIVSMLEPKTN----------SGKTKFPKESSKDDQHEEVSEEDVPTTS-TQRFM 451
                 :..:...||..:.|:|          |.||:..:...|  ::..:.|.::..:| .::|.
plant   360 FEENSEQPDKAGVSSFQKKSNLLSEGIVLDVSSKTRLGEAIEK--ENPSLREVEIDNSSPMEKFK 422

  Fly   452 DVLTQWRRTGDTKGTA------------------PSVPVKRRCSE-SEELVTR------TL---- 487
               .:.:..|..||..                  |.:.|..:.:: |::|.:|      ||
plant   423 ---FEIKACGTKKGEGSLSVHDVTHLDKTPSKGLPQLNVTEKVTDASKDLSSRSSFAQSTLNTFV 484

  Fly   488 -----KMQKIHTFLSQESP---NEQS---------------SKCEAESDAASDVDMAKKDKTQVS 529
                 |.:.|.|.|| |:|   |:.|               |:|..|.|...|:.::|:|.|...
plant   485 TMGKRKHENISTILS-ETPVLRNQTSSYRVEKSKFEVRALASRCLVEGDQLDDMVISKEDMTPSE 548

  Fly   530 LDNSFLNL--------------KELAK-----ESEAYDLLTK------PQNTPRIDCKVLTPIKS 569
            .|:...|.              :|..|     |..:.:.|||      .::.||  |.  .|::|
plant   549 RDSELGNRISPGTQADNVERHEREHEKPIRFEEPTSDNTLTKGDVERVSEDNPR--CS--QPLRS 609

  Fly   570 RRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPS 634
            ..::.            :|||: ::.|..|:.|  |....:.....:|..:|::
plant   610 VATVL------------DSPAQ-STGPKMFSTL--EFSFQNLRTRRLERLSRLQ----------- 648

  Fly   635 NFSSGEITTSLEE-------IASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQRE 692
              |:|.::..:..       .|::|:..:....:|:.|..               .:|.:||:|.
plant   649 --STGYVSKCMNTPQPKKCFAAATLELSQPDDEERKARAL---------------AAATSELERL 696

  Fly   693 IDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELT 757
            ..||||.||:::|||||||||.|||.|||||||||.|||:|||.|.|:|.|..|.|..|.||||:
plant   697 FRKEDFRRMQVLGQFNLGFIIAKLERDLFIVDQHAADEKFNFEHLARSTVLNQQPLLQPLNLELS 761

  Fly   758 AVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQD----- 817
            ...|:.:|.|:|:..:|||..|.:..||..|..||...|:||...||.||:.:||..|.|
plant   762 PEEEVTVLMHMDIIRENGFLLEENPSAPPGKHFRLRAIPYSKNITFGVEDLKDLISTLGDNHGEC 826

  Fly   818 --------APEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGR 874
                    :...:|| |||||||.||||||.|||||..|.:| .|::::..:.::|.||||||||
plant   827 SVASSYKTSKTDSIC-PSRVRAMLASRACRSSVMIGDPLRKN-EMQKIVEHLADLESPWNCPHGR 889

  Fly   875 PTMRHLINIAML--------INSDENDE 894
            ||||||:::..|        :|.|::|:
plant   890 PTMRHLVDLTTLLTLPDDDNVNDDDDDD 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	141/350 (40%)
		mutL	33..880	CDD:234630	317/963 (33%)
PMS1	NP_567236.1	mutl	17..329	CDD:273155	141/348 (41%)
		MutL_C	707..863	CDD:214857	82/156 (53%)