DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and MLH1

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_567345.2	Gene:	MLH1 / 826493	AraportID:	AT4G09140	Length:	737	Species:	Arabidopsis thaliana

Alignment Length:	756	Identity:	162/756 - (21%)
Similarity:	300/756 - (39%)	Gaps:	186/756 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ETNYNADTEEEPDVPPPTTALSGQ---IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGAT 64
            :::..|:.|||..  |.||.:..:   |:.:.:..|::|.:|:|:.....|||||||||:||.::
plant     4 DSSLTAEMEEEES--PATTIVPREPPKIQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSS 66

  Fly    65 LVEIKLKDQGLQSVEVSDNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCAL 129
            .:.:.:||.||:.::|||:|.|:...:|..:..::.|||:.:|.||..:.:.|||||||:|:..:
plant    67 SISVVVKDGGLKLIQVSDDGHGIRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYV 131

  Fly   130 SDMVIQTRHKSTDVGVKVE-----LDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNI 189
            :.:.:.|..|....|.:|.     ::||.:     .||...||.:::.|||..: :.||...:|.
plant   132 AHVTVTTITKGQIHGYRVSYRDGVMEHEPK-----ACAAVKGTQIMVENLFYNM-IARRKTLQNS 190

  Fly   190 KKEFTKMCQILQAYCLVTKGVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPL 254
            ..::.|:..:|....:....|...|..|   ||....:.:......:.:|.:::|...|.:|:.:
plant   191 ADDYGKIVDLLSRMAIHYNNVSFSCRKH---GAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKV 252

  Fly   255 KSPFGQGQLTEAELRADLESGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDR 319
            :                 .|..|.:..|                |.:|||||:..:.|.::.
plant   253 E-----------------VSSCDSSGCT----------------FDMEGFISNSNYVAKKTI--- 281

  Fly   320 QFFFVNSRPCDPKNIAKVMNEVY-HRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERIL 383
            ...|:|.|..:...:.:.:..|| .......:||:|::|...|..||:|:.|.|:::.:.|:.|:
plant   282 LVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVDINIHPTKKEVSLLNQEII 346

  Fly   384 LLALKKSL---LDTFGQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTT 445
            :..::..:   |.....| .|||.|.   |..::....|.|:..|.......|    ..:.||..
plant   347 IEMIQSEVEVKLRNANDT-RTFQEQK---VEYIQSTLTSQKSDSPVSQKPSGQ----KTQKVPVN 403

  Fly   446 STQRFMDVLTQWRRTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEA 510
            ...|                |..|.|..|                 :|.|| |..|.....|..:
plant   404 KMVR----------------TDSSDPAGR-----------------LHAFL-QPKPQSLPDKVSS 434

  Fly   511 ESDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFE 575
            .|...|.|...:             |.||.|..|...:|:.
plant   435 LSVVRSSVRQRR-------------NPKETADLSSVQELIA------------------------ 462

  Fly   576 FKTDAMALDKQESPAELNS-QPPSFTQLSEETDIASDEDDHIELPTRIEFDEEM--EEGLP--SN 635
                  .:|....|..|.: :..::..::::.......:.|:.|...:...:|:  ::.|.  ::
plant   463 ------GVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMYQQTLRRFAH 521

  Fly   636 FSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTE-INPNQNTSAE-----AELQREID 694
            |::.:::                  |....::|..|..|.| ::|..:|..:     ||:..|:.
plant   522 FNAIQLS------------------DPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELL 568

  Fly   695 K------EDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATD 729
            |      |::..:.|....||..:.|       |:||:..|
plant   569 KEKAEMLEEYFSVHIDSSANLSRLPV-------ILDQYTPD 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	155/733 (21%)
		HATPase_c	46..>151	CDD:294057	39/109 (36%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	30/143 (21%)
		MutL_C	703..847	CDD:214857	8/27 (30%)
MLH1	NP_567345.2	mutl	28..338	CDD:273155	92/354 (26%)
		HATPase_c	49..159	CDD:294057	39/109 (36%)
		MutL_Trans_MLH1	232..358	CDD:239565	31/161 (19%)
		Mlh1_C	453..737	CDD:293022	30/205 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820