Protein Alignment Pms2 and Mlh1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_112315.2
• Gene: Mlh1 / 81685
• RGDID: 620937
• Length: 758
• Species: Rattus norvegicus
• Alignment Length: 918
• Identity: 192/918 - (20%)
• Similarity: 350/918 - (38%)
• Gaps: 258/918 - (28%)

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            ::|.|:.:.:..|::|.:|:|:...|.|:||::||.:||.:|.:::.:|:.||:.:::.|||:|:
  Rat     4 VAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVIVKEGGLKLIQIQDNGTGI 68

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHE 152
            .:.:|:.:..::.|||::.|.||..:.|:|||||||:|:..::.:.|.|:........:.... :
  Rat    69 RKEDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYS-D 132

  Fly   153 GRIK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSN 216
            |::: ...|||...||.:.:.:||..: :.||...:|..:|:.|:.:::..|.:...|:    |.
  Rat   133 GKLQAPPKPCAGNQGTLITVEDLFYNI-ITRRKALKNPSEEYGKILEVVGRYSIHNSGI----SF 192

  Fly   217 HTPKGAKTIV-LQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLAD 280
            ...|..:|:. ::|..:...:.||.:|||...:.:|:
  Rat   193 SVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELI---------------------------- 229

  Fly   281 TTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRY 345
                ::..||    ....|::.|:||:..:...:..   ...|:|.|..:...:.|.:..||..|
  Rat   230 ----EVGCED----KTLAFKMNGYISNANYSVKKCI---FLLFINHRLVESAALKKAIEAVYAAY 283

  Fly   346 NVQQ-QPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSL-LDTFGQTPATFQMQNTT 408
            ..:. .||:||::..:..:||||:.|.|.::...:|..:|..:::.: ....|...:......|.
  Rat   284 LPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTL 348

  Fly   409 IVSMLEP-----KTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAP 468
            :..:..|     |:.:|........|.|..|   :.:.|.|.|..:.:|...|
  Rat   349 LPGLAGPSGEAVKSTTGIASSSTSGSGDKVH---AYQMVRTDSRDQKLDAFMQ------------ 398

  Fly   469 SVPVKRRC-SESEELV--TRT-----LKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAKKDK 525
              ||.||. |:.::.|  .||     ..|||          :::.|:..|..:||:|
  Rat   399 --PVSRRLPSQPQDPVPGNRTEGSPEKAMQK----------DQEMSELPAAMEAAAD-------- 443

  Fly   526 TQVSLD-NSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQESP 589
             ..||: .|.:...|:|                                              .|
  Rat   444 -SASLERESVIGASEVA----------------------------------------------PP 461

  Fly   590 AELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTS------LEEI 648
            |...|.|.|..:...|                 :.||||.|    |.|..|:|.:      :..:
  Rat   462 AAPPSSPGSSRKRHRE-----------------DSDEEMME----NDSRKEMTAACYPRRRIINL 505

  Fly   649 ASSLKAHEQQQRDRRTRTKLQRLR---FKTEINPN-------------QNTSAEAELQREIDKED 697
            .|.|...| :..||...|..:.||   |...:||.             ..|....||..:|...|
  Rat   506 TSVLSLQE-EINDRGHETLREMLRNHTFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYD 569

  Fly   698 FARMEIIGQFNLGFIIVKLEDDLFIVDQHATDE----------------KYNFETLQRTTQLEYQ 746
            ||        |.|.:.:.....||.:...|.|.                :|..|.|::..::
  Rat   570 FA--------NFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEM--- 623

  Fly   747 RLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATK--KVRLLGKPHSKRWEFGKEDID 809
             ||...::|:.....::           |....:|...|..:  .:.:|.......|:..||..:
  Rat   624 -LADYFSVEIDEEGNLI-----------GLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFE 676

  Fly   810 ELIFMLQDAPEGTICRPSRVRAMFASRACRKS-VMIGTALSRNTTMRRLITQMGEIEQPWNCPHG 873
            .|               |:..|:|.|  .||. ::..:|||...:     ...|...:||
  Rat   677 SL---------------SKECAVFYS--IRKQYILEESALSGQQS-----DMPGSPSKPW----- 714

  Fly   874 RPTMRHLI 881
            :.|:.|:|
  Rat   715 KWTVEHII 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	88/353 (25%)
		mutL	33..880	CDD:234630	188/905 (21%)
Mlh1	NP_112315.2	mutl	6..315	CDD:273155	88/353 (25%)
		Mlh1_C	504..758	CDD:465109	53/270 (20%)