Protein Alignment Pms2 and mlh3

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_005162267.2
• Gene: mlh3 / 568323
• ZFINID: ZDB-GENE-060810-45
• Length: 1144
• Species: Danio rerio
• Alignment Length: 1216
• Identity: 241/1216 - (19%)
• Similarity: 395/1216 - (32%)
• Gaps: 443/1216 - (36%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            ||::..:...::.||..:.||...|:||:.||||||||.|.:|:..:..: ::|.|||||:...:
Zfish     2 IKSLPINVQAQLRSGVAIFSLQQCVEELILNSIDAGATCVAVKIDIEACK-LQVIDNGSGMCLED 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMV---------IQTRHKSTDVGVKV 147
            :|.:..:|:|||.....||..:..:||||||:||:.:|::||         ::|..||.:....:
Zfish    66 MEKVGLRYNTSKCSSLEDLDNLHFYGFRGEAISSIVSLAEMVEISSRTKQSVKTYVKSFNETNAL 130

  Fly   148 ELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRI 212
            |:.....::   |.|   ||||.:.|||..:||||:           :|..:|:.       .||
Zfish   131 EVFEAQTVR---PSA---GTTVSVYNLFHNMPVRRK-----------RMDPVLET-------ERI 171

  Fly   213 LCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGA- 276
                                             ||..:.:.|..|       ........|:.|
Zfish   172 ---------------------------------RQRVEAISLMHP-------SVSFTVKKENSAH 196

  Fly   277 ---DLADTTSPQISTEDVERLNQA-----------DFQLEGFISSCRHGAGRSSRDRQFFFVNSR 327
               .|:.|:|.......:..||:|           .||:.|.|..    .|..:...||.|||.|
Zfish   197 MMVQLSKTSSTYYRFVQIHGLNRAQKLGEVNYEHEQFQITGHIGR----EGHYNNSLQFLFVNER 257

  Fly   328 PCDPKNIAKVMNEVYHR-------------YNVQQQP---------FIY-LNIITARSDVDVNLT 369
            ......|.|.:|.:..|             |.|...|         .|| :||....|:.|:.|.
Zfish   258 LLLKTRIHKTLNCLLKRVSGAARQNNSPTSYPVTSSPKQKGGYDLHGIYVINIKCHYSEYDICLE 322

  Fly   370 PDK---------RQLLINNERILLLALKKSL---LDTFG--------------------QTPATF 402
            |.|         ..|:...|.:.....|::|   |:|..                    .:..|.
Zfish   323 PAKSLIEFKDWDNVLICIEEGVKAFLTKENLVSELNTISNDGLPCSPVRNAESSEKQKRSSEETN 387

  Fly   403 QMQNTTI-------------VSMLE-----PKTNSGKT----KFPKESS-----------KDDQH 434
            :...|.|             |.|||     .::::||.    ..|.:::           |:|::
Zfish   388 EACETMIEKNDSSVVDVADGVQMLEQESIYTESDAGKALQSEDLPFQTTLVGAAEINNNHKEDEN 452

  Fly   435 ---EEVSEEDVPTTSTQRFM-------------DVLTQWRRTGDTKGTAPSVPVKRR--CSESEE 481
               ..:|..|.|....:..|             |.|.::.....|.      |.|||  .:::||
Zfish   453 AVCSNISHTDSPLAVNKNVMGSKSHKISLPEAQDSLQKFYTPNKTS------PKKRRMPLNDTEE 511

  Fly   482 ----------------------LVTRTLKMQKIHTFLSQE----------------SPNEQ---S 505
                                  |...|..:.|......:|                :||::   |
Zfish   512 DKHVFYGGPSKTFKATPPRKLTLSFETGSLDKFKRLFGKEAEKKQPSTEKTSLLNPNPNDRFVGS 576

  Fly   506 SKC------------------EAESDAASDVDMAKKDKTQVSLDNSFLNL-KELAKESEAYDLLT 551
            :.|                  ...::::|   :.||:|..::...|:|.. |||.::|
Zfish   577 TSCLDDLHHPVLRNSSGHPTTHRSTESSS---LNKKNKISLAAKCSYLKQDKELCRDS------- 631

  Fly   552 KPQNTPRIDCKVLTPIKSRRSIFE------FKTDAM-----ALDKQESP-AELNSQPPSFTQLS- 603
               |..:.|.....|  |:.|.||      ...|.:     .:|..:.| .|.::..||..:.|
Zfish   632 ---NFLKRDLSSFPP--SQDSCFEELEKTLLDEDVLFGSSGIVDSVDFPLIEQDTALPSVAEESH 691

  Fly   604 ----------------EETDIASDED-DHIELPTRIEFDEEMEEGLP------------------ 633
                            :|..:||..| .|.......:...|..|.:|
Zfish   692 LFNNNVTFFIGNESSVDEASVASQRDPQHSIAGNEGQTTNESVESIPVSNSWLAHYDSWLGKLVY 756

  Fly   634 -------SNFSSGEI-------TTSLEEIASSL-------------------------------K 653
                   |.::|..:       ||.:..:|.|:                               .
Zfish   757 INQVTGLSKYNSPPMEETQVPCTTDVTNMAVSVISKAGFEYRCYPFQSDIVLPFLPKPRAERAFN 821

  Fly   654 AHEQQQRDRRTRTKLQRLRFKTEINP---------NQNTSAEAE----------LQREIDKEDFA 699
            :....:.|.:....|..| |....||         ...||.:||          ......|....
Zfish   822 SGTDSREDAQAPDSLSTL-FSEWHNPVFIRPPEVAVDVTSGQAEGLAVKIHNILFPYRFTKNMIH 885

  Fly   700 RMEIIGQFNLGFIIVKLE-----------DD---LFIVDQHATDEKYNFETLQRTT--------- 741
            .|.:|.|.:..|:...:.           |:   |.:|||||..|:...|.|...:
Zfish   886 TMRVINQVDKKFLACLINTAGQNTSESSTDEGNLLVLVDQHAAHERVRLEGLIADSYEDDPDTPG 950

  Fly   742 --QLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKP------HS 798
              :|...|:..|..:.:|. .|:.||.....|.: |...:|......:..|.|...|      .|
Zfish   951 KKRLCSSRVTPPLEINVTE-EELRLLRSCQGFLR-GLALDVRFPKSESLSVFLESLPTCFIEKES 1013

  Fly   799 KRWEFGKEDIDELI-----------FMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNT 852
            .....|:..:.:.|           |.......|.:  |..|..:.||:||..::.....|::..
Zfish  1014 TELRRGRRSVIKTIAEDYLREHIELFRSTGRVRGIL--PLTVHNVLASQACHGAIKFNDVLNKEE 1076

  Fly   853 TMRRLITQMGEIEQPWNCPHGRPTMRHLINIAMLINSDENDEQEPP 898
            .. .|::.:.....|:.|.||||:   ::.:|.|.:.:|..:...|
Zfish  1077 CC-SLVSSLSSCRLPFQCAHGRPS---IVPLADLHHLEEQQDIPKP 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	237/1196 (20%)
		HATPase_c	46..>151	CDD:294057	43/113 (38%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	40/189 (21%)
		MutL_C	703..847	CDD:214857	37/185 (20%)
mlh3	XP_005162267.2	MutL	2..>462	CDD:333206	122/528 (23%)
		MutL_Trans_MLH3	206..349	CDD:239568	33/146 (23%)
		MutL_C	889..1070	CDD:214857	37/184 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820