Protein Alignment Pms2 and pms2

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_073774451.1
• Gene: pms2 / 565276
• ZFINID: ZDB-GENE-030131-686
• Length: 854
• Species: Danio rerio
• Alignment Length: 909
• Identity: 390/909 - (42%)
• Similarity: 533/909 - (58%)
• Gaps: 114/909 - (12%)

  Fly    24 SGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVE 88
            :|.||||.|.:||:|||||||||||.|||||||||||||||.|::||||.|::.|||||||.|||
Zfish    11 AGAIKAIDKQSVHQICSGQVVLSLATAVKELVENSIDAGATNVDVKLKDNGIELVEVSDNGKGVE 75

  Fly    89 EMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEG 153
            |.|.||:|.|:||||::||.||:.|||||||||||||||||||:.:.|.|:|..:|.::..||:|
Zfish    76 EQNYEGLTLKHHTSKLKEFSDLIHVETFGFRGEALSSLCALSDLSVVTCHESAQIGARLVYDHDG 140

  Fly   154 RIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHT 218
            |:.:..|..|..||||.|..||||||||.::|.||||||::||..:||:||:::.||||.|||..
Zfish   141 RLTQCVPHPRQHGTTVTLQKLFSTLPVRHKEFQRNIKKEYSKMIFVLQSYCIISTGVRITCSNQM 205

  Fly   219 PKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTS 283
            .:|.::.||.|.|...:..||.|:||.:|...|:|.:.                         .|
Zfish   206 GQGKRSTVLCTSGSNSMRDNIGAVFGPKQLQSLIPFRQ-------------------------IS 245

  Fly   284 PQISTEDVERLNQAD-----FQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYH 343
            |..|.::...|...|     |.::||:|...||.|||:.||||||:|.|||||..::|::|||||
Zfish   246 PNDSVKEDYGLGGVDVPKDLFNIDGFVSQGDHGVGRSATDRQFFFINKRPCDPVKVSKLVNEVYH 310

  Fly   344 RYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTF--GQTPATFQMQN 406
            .||..|.||:.|||..|...||||:||||||:|:..|::||..||.||:..|  |....:....:
Zfish   311 MYNRHQYPFVALNIAVASDCVDVNVTPDKRQILLQEEKLLLAILKSSLIAMFETGVNKISLNHIS 375

  Fly   407 TTIVSMLEPKTNSGKTKFPKESSKDDQH-----EEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGT 466
            ....||..|...|        :..|||.     |.::.:..|.||      :.....:...:...
Zfish   376 PAFTSMSRPTGTS--------ACSDDQEMGSVSETLTYDGPPKTS------INLAGLKEAFSNHQ 426

  Fly   467 APSVPVKRRCSESEELVTRTLKMQKIHTFLS------------QESPN--------EQSSKCEAE 511
            ||.:..|:   .|.:........:|:.:|:|            .:||.        :.|:.|..:
Zfish   427 APGIGSKQ---SSHKAACAGPSQKKMLSFVSCSKKVTDFVRPPLKSPTSFTAVSSIKLSTVCSVK 488

  Fly   512 SDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVL-TPIKSRRSIFE 575
            ..:|.|.|   .|.:..:...|..:..|:.:|:.:..:|....|...:..::: .|:......:|
Zfish   489 YKSAFDSD---ADGSGAASPKSAEDDPEIKQENHSESVLHHVINKTDVKAEIVDEPMDENLWSYE 550

  Fly   576 FKTDAMALDKQE---SP----AELNSQPPSFTQL----SEETDIASDEDDHIELPTRIEFDEEME 629
            ...:..:...|.   ||    |....:||:...|    |....:..|...:|:..|.:
Zfish   551 TLPETKSEQHQNRIFSPEAKRARREDEPPAQNCLVDFKSRNASLKFDAPVNIKKKTVV------- 608

  Fly   630 EGLPSNFSSGEITTSLEEI-ASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREI 693
              ||  ||..|::..::.: |...|::||:.:.|         ||:.:|||.:|.:||.||::||
Zfish   609 --LP--FSQQELSKRMQRLQAQRTKSNEQEPKYR---------RFRAKINPGENQTAEDELKKEI 660

  Fly   694 DKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTA 758
            .|:.|..|||||||||||||.|::.||||:||||||||||||.||:.|.|:.|||.|||:|.|.|
Zfish   661 SKDMFKEMEIIGQFNLGFIITKIKSDLFIIDQHATDEKYNFEMLQQNTVLKGQRLIVPQSLHLPA 725

  Fly   759 VNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTI 823
            ::|.||:.::::|.||||.|.:|.:|....:|:|:..|.||.|.||..||:||||||.|:| |.:
Zfish   726 ISETVLMENLEIFRKNGFDFLIDEDAQVMDRVKLVSLPTSKNWTFGPNDIEELIFMLSDSP-GIM 789

  Fly   824 CRPSRVRAMFASRACRKSVMIGTALSRNTT-MRRLITQMGEIEQPWNCPHGRPTMRHLINIAML 886
            |||||||.||||||||||||:||||  ||: |::|:..||||||||||||||||||||.|:.|:
Zfish   790 CRPSRVRQMFASRACRKSVMVGTAL--NTSEMKKLVLHMGEIEQPWNCPHGRPTMRHLANLDMI 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	190/355 (54%)
		mutL	33..880	CDD:234630	380/892 (43%)
pms2	XP_073774451.1	None