Protein Alignment Pms2 and PMS2

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001393795.1
• Gene: PMS2 / 5395
• HGNCID: 9122
• Length: 924
• Species: Homo sapiens
• Alignment Length: 939
• Identity: 389/939 - (41%)
• Similarity: 536/939 - (57%)
• Gaps: 146/939 - (15%)

  Fly     9 DTEEEPDVPPPTTALSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQ 73
            ||..||         :..||.|.:.:||:||||||||||:.|||||||||:|||||.:::||||.
Human    68 DTITEP---------AKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDY 123

  Fly    74 GLQSVEVSDNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRH 138
            |:..:||||||.||||.|.||:|.|:|||||:||.||..|||||||||||||||||||:.|.|.|
Human   124 GVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCH 188

  Fly   139 KSTDVGVKVELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAY 203
            .|..||.::..||.|:|.:::|..|..||||.:..||||||||.::|.||||||:.||.|:|.||
Human   189 ASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAY 253

  Fly   204 CLVTKGVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAEL 268
            |:::.|:|:.|:|...:|.:..|:.|.|...:..||.::||.:|...|:|..      ||..::.
Human   254 CIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFV------QLPPSDS 312

  Fly   269 RADLESGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKN 333
            ..: |.|...:|.         :..|    |.:.||||.|.||.||||.||||||:|.|||||..
Human   313 VCE-EYGLSCSDA---------LHNL----FYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAK 363

  Fly   334 IAKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTF--- 395
            :.:::|||||.||..|.||:.|||......||:|:||||||:|:..|::||..||.||:..|
Human   364 VCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSD 428

  Fly   396 ------GQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVL 454
                  .|.| ...::...|      |.::...:.|....:|......:.|:....|..|..:..
Human   429 VNKLNVSQQP-LLDVEGNLI------KMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAF 486

  Fly   455 TQWRRTGDTKGTAPSVPVKRRCSESEE---LVTRT---------LKMQKIHTFLSQESPNEQSSK 507
            : .|.|.:.|..:|..|..||....::   |.:.|         |:.|| ....|...|::.:.:
Human   487 S-LRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQK-EAVSSSHGPSDPTDR 549

  Fly   508 CEAESD--------------------------AASD---------VDMAKK-DKTQVSLDNSFLN 536
            .|.|.|                          |||.         ||..:| .||    |:||.:
Human   550 AEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKT----DDSFSD 610

  Fly   537 LKELAKESEA---YDLLTKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQESPAELNSQPPS 598
            :...:.:.:.   :.:|.:|.|       :.||...|     ||.:.:..........:|:|..|
Human   611 VDCHSNQEDTGCKFRVLPQPTN-------LATPNTKR-----FKKEEILSSSDICQKLVNTQDMS 663

  Fly   599 FTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRR 663
            .:|:    |:|            ::.::::   :|.:||...:...::::     .||.||.:..
Human   664 ASQV----DVA------------VKINKKV---VPLDFSMSSLAKRIKQL-----HHEAQQSEGE 704

  Fly   664 TRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHAT 728
            ...:    :|:.:|.|.:|.:||.||::||.|..||.|||||||||||||.||.:|:||||||||
Human   705 QNYR----KFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHAT 765

  Fly   729 DEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLL 793
            |||||||.||:.|.|:.|||..||.|.||||||.||:.::::|.||||.|.:|..||.|::.:|:
Human   766 DEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLI 830

  Fly   794 GKPHSKRWEFGKEDIDELIFMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNTT-MRRL 857
            ..|.||.|.||.:|:|||||||.|:| |.:||||||:.|||||||||||||||||  ||: |::|
Human   831 SLPTSKNWTFGPQDVDELIFMLSDSP-GVMCRPSRVKQMFASRACRKSVMIGTAL--NTSEMKKL 892

  Fly   858 ITQMGEIEQPWNCPHGRPTMRHLINIAML 886
            ||.|||::.|||||||||||||:.|:.::
Human   893 ITHMGEMDHPWNCPHGRPTMRHIANLGVI 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	182/350 (52%)
		mutL	33..880	CDD:234630	380/907 (42%)
PMS2	NP_001393795.1	mutl	75..406	CDD:273155	182/350 (52%)
		mutL	76..915	CDD:234630	383/914 (42%)