Protein Alignment Pms2 and PMS1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_000525.1
• Gene: PMS1 / 5378
• HGNCID: 9121
• Length: 932
• Species: Homo sapiens
• Alignment Length: 1012
• Identity: 251/1012 - (24%)
• Similarity: 401/1012 - (39%)
• Gaps: 245/1012 - (24%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            :|.:...||..:.|.|::.|:...||||:|||:|||||.|::||::.|...:||.|||.|::.::
Human     1 MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEGIKAVD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIK 156
            ...|..||:||||....||..:.|:|||||||.|:|.:::::|.||..:.:...:..||..|.|.
Human    66 APVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDGSGHIL 130

  Fly   157 KRSPCARGVGTTVLLANLFSTLPVRRRDFT--RNIKKEFTKMCQILQAYCLVTKGVRILCSNHTP 219
            .:.|...|.||||....||..||||::.::  :..|.|..|:..:|.::.::...:||:..::
Human   131 SQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDLRIVFVHN-- 193

  Fly   220 KGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSP 284
               |.::.|.               :|.:...:.|.|..|...:...|               |.
Human   194 ---KAVIWQK---------------SRVSDHKMALMSVLGTAVMNNME---------------SF 225

  Fly   285 QISTEDVERLNQADFQLEGFISSC--RHG-AGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRYN 346
            |..:|      ::...|.||:..|  .|. ...|:.:|.|.|:||||...|:|.|:   :.|.||
Human   226 QYHSE------ESQIYLSGFLPKCDADHSFTSLSTPERSFIFINSRPVHQKDILKL---IRHHYN 281

  Fly   347 V-------QQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQM 404
            :       :..|..:|.|....:||||||||||.|:|:.|:..:|:||:..:...:|..|:|...
Human   282 LKCLKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSY 346

  Fly   405 QNT-TIVSMLE---PKTNSGKTKFPKESSKDDQHEEVSEEDVP-------TTSTQRFMDVLTQWR 458
            :|. |.||..:   .||......|.|..|....:..|....:|       ..|.:...|.|....
Human   347 ENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQI 411

  Fly   459 RTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLS----QESPNEQSSKC--------EAE 511
            ..||. |..       .||.....:.:..|.......:|    :.|..|.|..|        ::|
Human   412 SIGDF-GYG-------HCSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSE 468

  Fly   512 SDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRID-CKVLTPIKSRRSIFE 575
            :.....:|.:.:::.:..|:||    .|::.:..:...:.|......|: .|:|.|.||...
Human   469 NGNKDHIDESGENEEEAGLENS----SEISADEWSRGNILKNSVGENIEPVKILVPEKSLPC--- 526

  Fly   576 FKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDE-----------------------DDH-- 615
                .::.:....|.::|....|..:.|...|..|.:                       .||
Human   527 ----KVSNNNYPIPEQMNLNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRP 587

  Fly   616 ---IELP-TRIEFDEEMEEGLPSNFSSGE-------ITTSLEEIASSLK-AHEQQQ----RDRRT 664
               ||.| |.:|......|.|....|..|       .|..||...|.:| |.||:.    :|.|.
Human   588 QFLIENPKTSLEDATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRK 652

  Fly   665 RTK-------LQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFI 722
            :.|       .|:.:.||.:: ||....|. ||.:|:|.   |.:.|....:.|.:..|
Human   653 KIKPTSAWNLAQKHKLKTSLS-NQPKLDEL-LQSQIEKR---RSQNIKMVQIPFSMKNL------ 706

  Fly   723 VDQHATDEKYNFETLQRTTQLE-------YQRLAVPQNLELTAVNEMVLLN-------------- 766
                    |.||:. |....||       ...|..|....:|:..|::|||
Human   707 --------KINFKK-QNKVDLEEKDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLL 762

  Fly   767 -------------------------HIDVFEK---------------------NGFKFEVDHEAP 785
                                     ::||..|                     ||||.::.....
Human   763 ENHKLPAEPLEKPIMLTESLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVS 827

  Fly   786 ATKK-VRLLGKPHSKRWEFGKEDIDELI--FMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTA 847
            .|:. :.:.|..:...: :|..|:.|::  .:.::|.|...|||.:|.:.....|.|.|..:...
Human   828 ITENYLEIEGMANCLPF-YGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMY 891

  Fly   848 LSR---NTTMRRLITQMG-EIEQPWNCPHGRPTMRHL 880
            ||:   ...:.|:..|.| ||::   |.||||...||
Human   892 LSKEDIQDIIYRMKHQFGNEIKE---CVHGRPFFHHL 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	249/1010 (25%)
		HATPase_c	46..>151	CDD:294057	46/104 (44%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	43/152 (28%)
		MutL_C	703..847	CDD:214857	37/213 (17%)
PMS1	NP_000525.1	mutl	1..318	CDD:273155	115/360 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..493		5/31 (16%)
		HMGB-UBF_HMG-box	572..636	CDD:238686	15/63 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R938
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850