DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pms2 and Pms1

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001009535.1	Gene:	Pms1 / 494322	RGDID:	1359511	Length:	919	Species:	Rattus norvegicus

Alignment Length:	1014	Identity:	237/1014 - (23%)
Similarity:	414/1014 - (40%)	Gaps:	256/1014 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            :|.:...||..:.|.|.:.|:...||||:|||:||||..:::||::.|...:|:.|||:|::.::
  Rat     1 MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGANSIDVKLENYGFDKIEIRDNGAGIKAVD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIK 156
            :..|..||:||||....||..:.|:|||||||.::|.::::|:.||..:.|...:..||..|.|.
  Rat    66 VPVMAVKYYTSKISSHEDLQTLTTYGFRGEALGAICNVAEVVVTTRTAADDFSTQYVLDGSGHIL 130

  Fly   157 KRSPCARGVGTTVLLANLFSTLPVRRRDFT--RNIKKEFTKMCQILQAYCLVTKGVRILCSNHTP 219
            .:.|...|.||||.:..||..|||||:.::  :..|.|...:..:|.:|.::...:||...::
  Rat   131 SQKPSHLGQGTTVTVLKLFKNLPVRRQFYSTPKKCKDELKNVQDLLISYAVLKPDLRITFVHN-- 193

  Fly   220 KGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSP 284
               |.::.|.          |.:...|.|     |.|..|                      |:.
  Rat   194 ---KAVIWQK----------SRVPDHRMA-----LMSVLG----------------------TAV 218

  Fly   285 QISTEDVER-LNQADFQLEGFISSCRHGAGRSSR-----DRQFFFVNSRPCDPKNIAKVMNEVYH 343
            ..:.|.||| ...:...|.|...  :|.|..:|.     :|.|.|:||||...|:|.|::...|:
  Rat   219 MGNMESVERYCEDSQIHLRGLFP--KHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRHYYN 281

  Fly   344 ----RYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQM 404
                :.:.:..|..:|.|....::||:||||||.|:|:.|:..:|:||:..|:..:|..|.|...
  Rat   282 LKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLLMTCYGPLPTTESY 346

  Fly   405 QN--------------TTIVSMLEPKTNSGKTKFPK-----------ESSKDDQH---EEV---- 437
            :|              ||...:|..|..|...|:|.           ||.|:..|   |::
  Rat   347 ENNRVDVSSANVVISETTETDVLFNKMESSGNKYPNADTLAIPFQNDESRKNTDHHLNEQINIGH 411

  Fly   438 ---------------SEEDVP---------------TTSTQRFMDVLTQWRRTG------DTKGT 466
                           :.:::|               |.|......:..:..|:|      |.|.|
  Rat   412 CDGHFSGEYSHINKDTFQNIPRNNLSSEANQSKHSETHSADSIEHIQGENGRSGTGENGEDGKKT 476

  Fly   467 APSVPVK------------RRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVD 519
            .|...::            ....|:.|.|...:..:.:...::...||.:          ..::.
  Rat   477 LPEKALEICADDWSKGNVFNSMGENIEPVKILVPQKSLSCKVTNSHPNPE----------PENLS 531

  Fly   520 MAKKDKTQVSLDNSFLNLKELAKESEAYDLL-TKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMAL 583
            :....:|...:||.       ..:..||||: ::....|...|.:.  |:..|:.|..:.....|
  Rat   532 VGPGSRTSNVIDNR-------PGQLTAYDLISSRAVKKPMSACALF--IQDHRTQFLAENPKTGL 587

  Fly   584 DKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLPSNFSSGEITTSLEEI 648
              ::..|::.:|   :..||||.....:|....:|.   .::.:|::.:..     |...||::.
  Rat   588 --EDVTAQIKAQ---WETLSEEEKHKYEEKAKKDLE---RYNNQMKKAIEQ-----EAQVSLKDG 639

  Fly   649 ASSLKA---------HE--------------QQQRDRRTRT-KLQRLRFKTEINPNQNTSAEAEL 689
            ...|:|         |:              |.|.::::.. |:.::.|..|     |.......
  Rat   640 RKKLRATGAWGCTQRHKVKDLSNQPKLDELFQSQNEKKSENIKITKIPFSME-----NLKVNFNK 699

  Fly   690 QREIDKEDFARMEIIGQFNLGF---IIVKLEDDLFIVDQHATDEKYNFETLQRTTQLE-YQRLAV 750
            |:|:|.|:  :.||....:|.|   .:|....|:.:::.:..:|...|:.|     || ::.||.
  Rat   700 QKEVDLEE--KDEICLIHSLKFPDAWLVTSRADVMLLNPYRVEEALLFKRL-----LENHKFLAE 757

  Fly   751 PQNLELTAVNEMVLLN---HIDVFEK---------------------NGFKFEVDHEAPATK--- 788
            |  |:...|....|.|   :::|..|                     ||||..:.....:.:
  Rat   758 P--LDKPIVLTESLFNGSDYLEVLHKMSTVEERCRGSVYLCDPRLTANGFKIRLTPGVSSAENYL 820

  Fly   789 KVRLLGK--PHSKRWEFGKEDIDELI--FMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALS 849
            ::..:.|  |.     :|..|:.|::  .:.::|.|...|||.:|.......|.|.|..:...|.
  Rat   821 EIEGMAKCLPF-----YGVMDLKEILNAIVNKNAKEIYECRPRKVINYLEGEAVRLSRQLPMYLP 880

  Fly   850 RNTTMRRLITQM-----GEIEQPWNCPHGRPTMRHLINI 883
            :. .::.||.:|     .||:   .|.||||.:.|||::
  Rat   881 QE-DVQDLIYKMKHQFGKEIK---GCVHGRPFLHHLIHL 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	234/1009 (23%)
		HATPase_c	46..>151	CDD:294057	43/104 (41%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	41/152 (27%)
		MutL_C	703..847	CDD:214857	37/178 (21%)
Pms1	NP_001009535.1	mutl	1..318	CDD:273155	111/360 (31%)
		HATPase_c	18..>102	CDD:280651	37/83 (45%)
		MutL_Trans_hPMS_1_like	205..338	CDD:239567	44/161 (27%)
		HMGB-UBF_HMG-box	561..625	CDD:238686	14/73 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820