Protein Alignment Pms2 and mlh1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_956953.1
• Gene: mlh1 / 393632
• ZFINID: ZDB-GENE-040426-1600
• Length: 724
• Species: Danio rerio
• Alignment Length: 629
• Identity: 135/629 - (21%)
• Similarity: 269/629 - (42%)
• Gaps: 151/629 - (24%)

  Fly    23 LSGQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGV 87
            ::|.|:.:.:..|::|.:|:::...|.|:||::||.:||.:|.::|.:|:.||:.:.:.|||:|:
Zfish     1 MAGVIRRLDETVVNRIAAGEIIQRPANAIKEMMENCLDAKSTNIQITVKEGGLKLILIQDNGTGI 65

  Fly    88 EEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDH- 151
            .:.::|.:..::.|||::.|.||..:.|:|||||||:|:..::.:.|.|  |:.|.......::
Zfish    66 RKDDMEIVCERFTTSKLKSFDDLSSIATYGFRGEALASISHVAHVTITT--KTADAKCAYRANYC 128

  Fly   152 EGRIKK-RSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCS 215
            :|::|. ..|||...||.:.:.:||..:..||:.. ::..:|::::.:::..|.:...|......
Zfish   129 DGKLKSPPKPCAGNQGTLISVEDLFYNVSTRRKAL-KSPSEEYSRIVEVVSRYAIHNSGKSFSVK 192

  Fly   216 NHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLAD 280
            .   :|.....::|..:..|:.||..:||...:.:|:
Zfish   193 K---QGEMVADVKTLPNASVLDNIRVVFGVAVSRELI---------------------------- 226

  Fly   281 TTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRY 345
                ::..||    .:..|:::|:||:..:...:..   ...|:|.|..:...:.|.:..||..|
Zfish   227 ----EVECED----QKFAFKVKGYISNANYSVKKCI---LILFINHRLVESSALKKAIETVYTAY 280

  Fly   346 NVQQ-QPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQMQNTTI 409
            ..:. .||:||::..|..::|||:.|.|.::...:|..::.:::|             .::|..:
Zfish   281 LPKNTHPFLYLSLEIAPQNIDVNVHPTKHEVHFLHEDSIIESIQK-------------HIENKLL 332

  Fly   410 VSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVKR 474
            .|      ||.:|.|                      ||..:            .|.:.|..|.:
Zfish   333 GS------NSSRTYF----------------------TQTLL------------PGLSASASVAK 357

  Fly   475 RCSES---------EELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAKKDKTQVSL 530
            ..|.|         .::|....|.||:..|| |.|.:..||..:.:::..|....|.:|  .|.|
Zfish   358 ASSSSADPQERVYAHQMVRTDSKAQKLDAFL-QPSASSSSSAAQRKTEKTSSTSTAVQD--SVEL 419

  Fly   531 DNSFL-------------------------------NLKELAKESEAYDLLTKPQNTPRIDCKVL 564
            |::.|                               :::|:.::..|..|       ||.....|
Zfish   420 DDAELLTAADVEPCGGEDPQTDAQPPGDEAPPRKRPHVEEVKEDLTAASL-------PRRRIVKL 477

  Fly   565 TPIKSRRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDI 608
            |.||..|...|.:|.....:..::.:.:.|..|.:|.:..:|.:
Zfish   478 TSIKGLRDQIELQTHKGLQELLQNHSFVGSVSPQWTLVQHQTKL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	134/626 (21%)
		HATPase_c	46..>151	CDD:294057	37/104 (36%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	28/143 (20%)
		MutL_C	703..847	CDD:214857
mlh1	NP_956953.1	mutl	3..312	CDD:273155	87/353 (25%)
		HATPase_c	28..>127	CDD:294057	36/100 (36%)
		MutL_Trans_MLH1	208..332	CDD:239565	32/175 (18%)
		Mlh1_C	475..724	CDD:293022	11/47 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820