Protein Alignment Pms2 and pms1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_958476.2
• Gene: pms1 / 368631
• ZFINID: ZDB-GENE-030616-528
• Length: 896
• Species: Danio rerio
• Alignment Length: 979
• Identity: 245/979 - (25%)
• Similarity: 417/979 - (42%)
• Gaps: 220/979 - (22%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            :||:..:||..:||.||:.|:...||||:|||:|||::.:|:||::.||..:||.|||||::..:
Zfish     1 MKALPPETVRLLCSSQVITSVLNVVKELIENSLDAGSSSLEVKLENYGLDRIEVRDNGSGIKATD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIK 156
            :..|..|::||||....||..:||:|||||||:|:||:|:::|.|:....|..::..:||.|:|.
Zfish    66 VSVMAVKHYTSKISCHEDLEQLETYGFRGEALASICAISEVIITTKTADDDFSIQYSVDHNGQIV 130

  Fly   157 KRSPCARGVGTTVLLANLFSTLPVRRRDF--TRNIKKEFTKMCQILQAYCLVTKGVRILCSNHTP 219
            .:.|...|.||||..||||..|||||:.:  |:..|.|..::..:|.||.::...:|:..|::
Zfish   131 SQKPSHLGQGTTVCAANLFKNLPVRRQYYSNTKKCKDELKRVQNLLMAYAVIKPELRVTLSHN-- 193

  Fly   220 KGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRAD---LESGADLADT 281
               |.:|.|.....:....:.|:.||...|:::|:     |....:.|:..|   .:.|:||..|
Zfish   194 ---KAVVWQKSRVSDHRTALMAVLGAASVANMLPV-----QHHQEQPEITIDGFFPKPGSDLNST 250

  Fly   282 TSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVY---- 342
            :|                               |:.|:.|.||||||...|.|.|::.:.|
Zfish   251 SS-------------------------------STTDKSFIFVNSRPVHHKEILKLIKQYYTSAQ 284

  Fly   343 -------HRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPA 400
                   .||     |...:||....|.|||||||||.::::.|:..:||:::..|:..:|.:..
Zfish   285 SNSESVSRRY-----PTFMMNITIPASTVDVNLTPDKTEVMLQNKDEVLLSVETMLISLYGYSNG 344

  Fly   401 TFQMQNT----TIVSMLEPKTNS-----GKTKFPKESSK--DDQHEEVSEEDVPTTSTQRFMDVL 454
            ...::..    .:.|:.|||..|     ...:.|::||.  :.|..|:|..:...||:.   .:.
Zfish   345 EENLKTAGNPPDVTSLDEPKRTSPDISLKHPELPEDSSSNAEKQDGELSLSNTANTSSS---SIS 406

  Fly   455 TQW-RRTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDV 518
            ..| ....|......||||       :::|..:......::..:.||.:...|:..||:.:|..|
Zfish   407 EDWVINRSDLDSINCSVPV-------DDVVMNSTADLNSNSPKASESDSGPESQISAENWSAGRV 464

  Fly   519 ----------------------DM----AKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTP 557
                                  |:    ||..|:..|...|.:.::::||.: ||:|::
Zfish   465 FSNQITGEYLEPVKLHIPKAIEDLGGTEAKSVKSSPSKKPSNVIVEKMAKLT-AYELIS------ 522

  Fly   558 RIDCKVLTPIKSRRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRI 622
              :..|..| .|..|:||..|.:..|  ||:|   .:.|...|..::|...:..|:|      |.
Zfish   523 --NRSVRQP-SSAFSLFEQDTRSQVL--QENP---KASPQDVTAAAKERWESLGEED------RK 573

  Fly   623 EFDEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQ------RLRFKTEINPNQ 681
            :::.:.|:                    ||.|: ..||.|.....:|      ::..::.:|..|
Zfish   574 KYEGKAEK--------------------SLNAY-NLQRKRAAEGGVQCGEGKKQMSAESPLNKAQ 617

  Fly   682 NTSAEAEL--QREIDK-----EDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQR 739
            ....:|.|  |:.:||     ....|........|.|.|..|:..|.::.:.::........:.|
Zfish   618 GVKRKAPLANQQALDKLFSSQPSSKRSPAKISKPLPFTIATLKQSLNLLSEQSSSSVQGLRLVNR 682

  Fly   740 TTQ-----------------------LEYQRLAVPQNLELTAVNEMVLL--------NHIDV--- 770
            ...                       |.::||.....|....:...|||        .::||
Zfish   683 LASHGAWVVLCGRKLMLLNPFRVEEALLFKRLLEDNILPTVRLQTPVLLTDGVLGGPEYMDVLLN 747

  Fly   771 FEKNGFKFEVDHEAPATK------KVRLLGKPHSKRWE------------FGKEDIDELIFMLQD 817
            .:|:|.:|..|......:      ::|::..|.|....            ||..|:.|::..::.
Zfish   748 MKKDGPEFNGDISLTDPRLVANGFEIRMISGPQSSERHVEVMGMADCMPFFGIGDLREILQAIKA 812

  Fly   818 APEGTI--CRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLITQMGEI-EQPWNCPHGRPTMRH 879
            ....|:  |||.:|.....|.|.|.:..:..:|||......|.....|: ::...|.|..|...:
Zfish   813 RGAKTVAQCRPRKVSHYLESEAVRLARQLPLSLSRADVTNTLCRMQQELQDESQVCIHRLPFFHN 877

  Fly   880 LINI 883
            |:.:
Zfish   878 LVTL 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	126/364 (35%)
		mutL	33..880	CDD:234630	242/968 (25%)
pms1	NP_958476.2	mutl	1..320	CDD:273155	126/364 (35%)
		HMG-box_PMS1	525..597	CDD:438801	24/104 (23%)