Protein Alignment Pms2 and Mlh1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_477022.1
• Gene: Mlh1 / 35796
• FlyBaseID: FBgn0011659
• Length: 664
• Species: Drosophila melanogaster
• Alignment Length: 755
• Identity: 165/755 - (21%)
• Similarity: 310/755 - (41%)
• Gaps: 189/755 - (25%)

  Fly    25 GQIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEE 89
            |.|:.:.:..|::|.:|:::...|.|:|||:|||:||.:|.:::::|..||:.:::.|||:|:..
  Fly     8 GVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRR 72

  Fly    90 MNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGR 154
            .:|..:..::.|||:..|.||..:.|||||||||:|:..::.:.|||:......|.|... .:|:
  Fly    73 EDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATY-ADGK 136

  Fly   155 IK-KRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHT 218
            :: :..|||...||.:.:.:||..:| :||...|:..:||.::.::|..|.:           |.
  Fly   137 LQGQPKPCAGNQGTIICIEDLFYNMP-QRRQALRSPAEEFQRLSEVLARYAV-----------HN 189

  Fly   219 PKGAKTIVLQTHGDQEV----------MANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLE 273
            |:...|  |:..||.:.          ..||..|:||..:.:|:
  Fly   190 PRVGFT--LRKQGDAQPALRTPVASSRSENIRIIYGAAISKELL--------------------- 231

  Fly   274 SGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVM 338
                           |...|.....|:.|..|:...:.|   .:.:...|:|.|..:...:...:
  Fly   232 ---------------EFSHRDEVYKFEAECLITQVNYSA---KKCQMLLFINQRLVESTALRTSV 278

  Fly   339 NEVYHRYNVQ-QQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATF 402
            :.:|..|..: ..||:|:::.....::|||:.|.|.::....:..::.::|:       |..|..
  Fly   279 DSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQ-------QVEARL 336

  Fly   403 QMQNTTIVSMLEPKTNSGKTKFP-----KESSKDDQHEEV-SEEDVPTTSTQRFMDVLTQWRRTG 461
            ...|.|       :|...:.:.|     .|:...|:.:.: .:|.|.|.||::.:|
  Fly   337 LGSNAT-------RTFYKQLRLPGAPDLDETQLADKTQRIYPKEMVRTDSTEQKLD--------- 385

  Fly   462 DTKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESDAASDVDMAKKDKT 526
              |..||.|       :|:..|:              .|.::::|:...||   ..|..|||.:
  Fly   386 --KFLAPLV-------KSDSGVS--------------SSSSQEASRLPEES---FRVTAAKKSR- 423

  Fly   527 QVSLDNSFLNLKELAKESEAYDLLTKPQNTPRIDCKVLTPIKSRRSIFEFKTDAMALDKQ----- 586
            :|.| :|.|::::..:...:..|.:..:|...:.|     :..||::|:.:|.....:.:
  Fly   424 EVRL-SSVLDMRKRVERQCSVQLRSTLKNLVYVGC-----VDERRALFQHETRLYMCNTRSFSEE 482

  Fly   587 ----------ESPAELNSQPP----SFTQLSEETDIAS---DEDDHIEL------------PTRI 622
                      ::.:|:...||    ....||.|::.|.   ::.|..||            |...
  Fly   483 LFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKAELADGAADILLKKAPIMR 547

  Fly   623 EF------DEEMEEGLPSNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQ 681
            |:      ::.|.|.|||..                    .|.|.......:..||..||::..|
  Fly   548 EYFGLRISEDGMLESLPSLL--------------------HQHRPCVAHLPVYLLRLATEVDWEQ 592

  Fly   682 NTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLF 721
            .|.......||..: .:|:::.......||....:|..||
  Fly   593 ETRCFETFCRETAR-FYAQLDWREGATAGFSRWTMEHVLF 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	92/362 (25%)
		mutL	33..880	CDD:234630	163/747 (22%)
Mlh1	NP_477022.1	mutl	8..317	CDD:273155	92/362 (25%)
		Mlh1_C	426..664	CDD:465109	43/233 (18%)