DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pms2 and Mlh3

DIOPT Version :9

Sequence 1:	NP_477023.1	Gene:	Pms2 / 36705	FlyBaseID:	FBgn0011660	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001101513.1	Gene:	Mlh3 / 314320	RGDID:	1309227	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	739	Identity:	168/739 - (22%)
Similarity:	291/739 - (39%)	Gaps:	172/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            |:.:..:...|:.||..:.||...|:||..|||||.||.|.|::..:..| |:|.|||.|:...:
  Rat     2 IRCLSDEVQAKLRSGLALSSLGQCVEELTLNSIDAEATCVAIRVNMETFQ-VQVIDNGLGMAGDD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGR-- 154
            :|.:..:|.|||.....||.....:|||||||:|:..::..|..:..|||.:...|::...|:
  Rat    66 VEKVGNRYFTSKCHSVRDLENPTFYGFRGEALASIADMASAVEISSKKSTTLKTFVKMFQNGKAL 130

  Fly   155 IKKRSPCAR-GVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHT 218
            ..:.:...| .|||||.:.|||...||||:.....:  ||.|:.|.::|..|:...:.....|..
  Rat   131 AAREADLTRPSVGTTVTVYNLFYQFPVRRKSMDPRL--EFEKVRQRVEALSLMHPSISFSLRNDV 193

  Fly   219 PKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQ-LTEAELRADLESGADLADTT 282
               :.:::||....:::.:....|:|             .|:.| |.|...:
  Rat   194 ---SGSMILQLPKTKDICSRFCQIYG-------------LGKSQKLREIHYK------------- 229

  Fly   283 SPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSR-------------------- 327
                         ..:|:..|:|||..|    .:::.||.|||.|
  Rat   230 -------------YKEFEFNGYISSEAH----YNKNMQFLFVNRRLVLRTKLHKLIDFLLRKESI 277

  Fly   328 PCDPKN--IAKVMNEVYHRYNVQQQPFIY-LNIITARSDVDVNLTPDKRQLLINNERILLLALKK 389
            .|.|||  .::.||......:..:...|| :|:.....:.||.:.|                 .|
  Rat   278 ICRPKNGSASRQMNSSPRHRSASELHGIYVINVQCPFCEYDVCIEP-----------------AK 325

  Fly   390 SLLDTFGQTPATFQMQNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVL 454
            :|::        ||..:|.::.:.|     |..||.|:   :....|:|.||:...:......::
  Rat   326 TLIE--------FQNWDTVLICVQE-----GIKKFLKQ---EKLFVELSSEDIKEFNEDNGFSLI 374

  Fly   455 TQWRRTGDTKGTAPSVPVKRRCS---ESEELVTRTLK-MQKIHTFLSQESPNEQSS-----KCEA 510
            ....:|..|.........:..|:   :|.|:.....| :::|.|..::.:.|...|     |.|.
  Rat   375 GTTLQTQSTHEKCDQSSFQEACNNILDSYEMFNLQSKAVKRIATLENRTTQNSGDSGAIRKKTED 439

  Fly   511 ESDAASDVDMAKKDKTQVSL---DNSFLNLK----ELAKESEAYDLLTKPQNTPRIDCKVLTPIK 568
            .....|| |:..:...:.:|   |:::|..:    ::||.|.|      .:|.           |
  Rat   440 SYTYESD-DLGHRKTVESALYNSDSAYLGSRMSEEDIAKTSHA------GENE-----------K 486

  Fly   569 SRRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIEFDEEMEEGLP 633
            .::|:.|.:|       .|.|.|  :.|..|:...:......:.:..:|:..:......|...:|
  Rat   487 WKKSLLENRT-------SERPHE--TSPKMFSSPIQTHHPLEESEADLEIEMKSSTVNVMAANIP 542

  Fly   634 SNFSSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDF 698
            .|   .||.:.||::..:            ...:.|.|.|:|.:...|.|..:.|.::|:.....
  Rat   543 PN---SEIQSQLEQLEDA------------PEVECQPLPFETTLLRAQGTLKKKERKKELSSHGR 592

  Fly   699 ARMEIIGQFNL---GFI--IVKLE 717
            ..:...||..|   |||  :|:.|
  Rat   593 VNVFSYGQVKLCSTGFITHVVQRE 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	168/739 (23%)
		HATPase_c	46..>151	CDD:294057	41/104 (39%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	30/166 (18%)
		MutL_C	703..847	CDD:214857	8/20 (40%)
Mlh3	NP_001101513.1	mutl	1..326	CDD:273155	98/389 (25%)
		HATPase_c	22..149	CDD:280651	47/127 (37%)
		MutL_Trans_MLH3	206..349	CDD:239568	39/215 (18%)
		MutL_C	1179..1359	CDD:214857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D735423at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820