Protein Alignment Pms2 and Pms2

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001386724.1
• Gene: Pms2 / 288479
• RGDID: 1305483
• Length: 853
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 379/937 - (40%)
• Similarity: 527/937 - (56%)
• Gaps: 158/937 - (16%)

  Fly    19 PTTALSGQ----IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVE 79
            ||...|.:    ||.|...:||:||||||||||:.|||||:|||:|||||.::::|||.|:..:|
  Rat     3 PTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATSIDLRLKDYGVDLIE 67

  Fly    80 VSDNGSGVEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVG 144
            |||||.||||.|.||:..|:||||||||.||..|||||||||||||||||||:.|.|.|.|..:|
  Rat    68 VSDNGCGVEEENFEGLALKHHTSKIREFADLTQVETFGFRGEALSSLCALSDVTISTCHVSASIG 132

  Fly   145 VKVELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKG 209
            .::.|||.|:|.:::||.|..||||.:.|||.|||||.::|.||||||:.||.|:|||||:::.|
  Rat   133 TRLVLDHNGKIIQKTPCPRPKGTTVSVQNLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAG 197

  Fly   210 VRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVP-LKSPFGQGQLTEAELRADLE 273
            :|:.|:|...:|.:..|:.|.|...:..||.::||.:|...||| ::.|.......|..|.|
  Rat   198 IRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSA--- 259

  Fly   274 SGADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVM 338
                   ..:|           |:.|::.||||.|.|||||||.||||||:|.|||||..:::::
  Rat   260 -------CGTP-----------QSPFRISGFISQCTHGAGRSSTDRQFFFINQRPCDPAKVSRLV 306

  Fly   339 NEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQ 403
            |||||.||..|.||:.||:......||:|:||||||:|:..|::||..||.||:..|........
  Rat   307 NEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLMGMFDSDANKLS 371

  Fly   404 MQNTTIVSMLEPKTNSGKTKFPKESSKDDQHE-EVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTA 467
            :....::::   :.|..|....:...:::... .::.|:....|..|..:..: ..||.:||...
  Rat   372 VNQQPLLNV---EGNLVKLHTAEVGEQENSPSLRITAEEKRVASVSRLREAYS-LHRTTETKSWG 432

  Fly   468 P-------SVPVKRR----------------CSESEELVTRTLKMQKIHTFLSQESPNEQSSKCE 509
            |       |.|.::|                |...::||:.|            :||.:...:.:
  Rat   433 PETPELKQSFPSQKRGVSSSCPSDIISYRGLCGSQDKLVSPT------------DSPGDCMDREK 485

  Fly   510 AESDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRI------DCKVLTPIK 568
            .|.|:.       ...|....:..|                    :||.:      ||.|.:|
  Rat   486 GEKDSG-------LSSTSAGSEEGF--------------------STPEVASSFSSDCNVSSP-- 521

  Fly   569 SRRSIFEFKTDAMALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIE------------LPTR 621
                             ::.|::.|:.  ...|..|..|..|....|::            .|||
  Rat   522 -----------------EDRPSQENTN--CGEQFLEVDDHLSGTGHHLKPEDNGYKCRASLPPTR 567

  Fly   622 IE---------FDEEMEEGLPSNFSSGEITT-------------SLEEIASSLKAHEQQQRDRRT 664
            :.         .|.....|:|.|.|:.|:..             ||..:|..:|  :.|...:::
  Rat   568 LSPSNAKRFRTEDRPSNVGVPQNTSAAEVDVAVKINKKIVLLDFSLSSLAKQMK--QLQHLKQQS 630

  Fly   665 RTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDDLFIVDQHATD 729
            :::....:|:.:|.|.:|.:||.||:|||.|..||.|||:||||||||:.||::|||:|||||.|
  Rat   631 KSEHNYRKFRAKICPGENQAAEDELRREIRKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAAD 695

  Fly   730 EKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFEVDHEAPATKKVRLLG 794
            ||||||.||:.|.|:.|||..||.|.||||||.||:.::::|.||||.|.:|.:||.|::.:|:.
  Rat   696 EKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFIIDEDAPVTERAKLIS 760

  Fly   795 KPHSKRWEFGKEDIDELIFMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNTTMRRLIT 859
            .|.||.|.||.:|||||||||.|:| |.:|||||||.||||||||||||||||||. :.|::||:
  Rat   761 LPTSKNWTFGPQDIDELIFMLSDSP-GVMCRPSRVRQMFASRACRKSVMIGTALSA-SEMKKLIS 823

  Fly   860 QMGEIEQPWNCPHGRPTMRHLINIAML 886
            .|||::.|||||||||||||:.|:.::
  Rat   824 HMGEMDHPWNCPHGRPTMRHIANLDVI 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	183/355 (52%)
		mutL	33..880	CDD:234630	371/911 (41%)
Pms2	NP_001386724.1	mutl	13..344	CDD:273155	172/331 (52%)
		mutL	14..844	CDD:234630	357/894 (40%)