Protein Alignment Pms2 and MLH3

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001035197.1
• Gene: MLH3 / 27030
• HGNCID: 7128
• Length: 1453
• Species: Homo sapiens
• Alignment Length: 978
• Identity: 221/978 - (22%)
• Similarity: 364/978 - (37%)
• Gaps: 272/978 - (27%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            ||.:..:...|:.||..:.||...|:||..|||||.|..|.:::..:..| |:|.|||.|:...:
Human     2 IKCLSVEVQAKLRSGLAISSLGQCVEELALNSIDAEAKCVAVRVNMETFQ-VQVIDNGFGMGSDD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIK 156
            :|.:..:|.|||.....||.....:|||||||:::..::..|..:..|:..:...|:|...|:..
Human    66 VEKVGNRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKAL 130

  Fly   157 KRSPCARGV-----GTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSN 216
            |  .|...|     ||||.:.|||..|||||:  ..:.:.||.|:.|.::|..|:...:.....|
Human   131 K--ACEADVTRASAGTTVTVYNLFYQLPVRRK--CMDPRLEFEKVRQRIEALSLMHPSISFSLRN 191

  Fly   217 HTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADT 281
            ..   :.::|||....::|.:....|:|             .|:.|    :||
Human   192 DV---SGSMVLQLPKTKDVCSRFCQIYG-------------LGKSQ----KLR------------ 224

  Fly   282 TSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSR------------------- 327
               :||      ....:|:|.|:|||..|    .:::.||.|||.|
Human   225 ---EIS------FKYKEFELSGYISSEAH----YNKNMQFLFVNKRLVLRTKLHKLIDFLLRKES 276

  Fly   328 -PCDPKN--IAKVMN-EVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLAL- 387
             .|.|||  .::.|| .:.||...:......:|:.....:.||.:.|.|..:...|...||..:
Human   277 IICKPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFCIQ 341

  Fly   388 ---------KKSLLDTFGQTPATFQMQN--TTIVSMLEPKTNSGKTKFPKESSKD--DQHE---- 435
                     :|..::..|:....|...|  :...:.|:.:..|.:....:|:..:  |.:|
Human   342 EGVKMFLKQEKLFVELSGEDIKEFSEDNGFSLFDATLQKRVTSDERSNFQEACNNILDSYEMFNL 406

  Fly   436 -------EVSEEDVPTTSTQRFMDVLTQWRRTGD-------------TKGTAPSVPVK-RRCSES 479
                   :.:.|:|.|.|::   |.....:.|.|             :|.|.||:..| ..||||
Human   407 QSKAVKRKTTAENVNTQSSR---DSEATRKNTNDAFLYIYESGGPGHSKMTEPSLQNKDSSCSES 468

  Fly   480 EELVTRTLKMQKIHTFLSQESPNEQSSK-----CEAESDAASDVDM-AKKDKTQVSLDNSFLNLK 538
            :.|...|:       ..|:...||:..|     ...|:...:.::| ....:|....:.|..:|
Human   469 KMLEQETI-------VASEAGENEKHKKSFLEHSSLENPCGTSLEMFLSPFQTPCHFEESGQDL- 525

  Fly   539 ELAKESE-----AYDLL--TKPQNTPR-------IDCKVLTPIKS-------------------- 569
            |:.|||.     |.::|  .:.||.|:       :.|:.| |..:
Human   526 EIWKESTTVNGMAANILKNNRIQNQPKRFKDATEVGCQPL-PFATTLWGVHSAQTEKEKKKESSN 589

  Fly   570 --RRSIFE----------FKTDAMALDKQES------------PAELNSQPP--SFTQLSEET-- 606
              ||::|.          |.|..:..:|.:|            |....:|..  :.|:.|.||
Human   590 CGRRNVFSYGRVKLCSTGFITHVVQNEKTKSTETEHSFKNYVRPGPTRAQETFGNRTRHSVETPD 654

  Fly   607 --DIASD-EDDHIELPTRIEFDEEMEEGLP----------SNFSSG----EITTSLEEIASSLKA 654
              |:||. ..:..:||.:......:..||.          |.|..|    :....|.:.:.|...
Human   655 IKDLASTLSKESGQLPNKKNCRTNISYGLENEPTATYTMFSAFQEGSKKSQTDCILSDTSPSFPW 719

  Fly   655 HEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIVKLEDD 719
            :.....|.|...||  :.|...| ..:..|..::|.   ..|.|.|     |:.      |:|:.
Human   720 YRHVSNDSRKTDKL--IGFSKPI-VRKKLSLSSQLG---SLEKFKR-----QYG------KVENP 767

  Fly   720 LFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQN-LELTAVNEMVLLNHID----------VFEK 773
            |   |...  |:.|..|...:.|:|...|...:| ||.:.|.::..:.|.|          :...
Human   768 L---DTEV--EESNGVTTNLSLQVEPDILLKDKNRLENSDVCKITTMEHSDSDSSCQPASHILNS 827

  Fly   774 NGFKFEVD-----------HEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTICRPS 827
            ..|.|..|           .|:|.|.|...|         |.::.:|     |:.:.|....:.|
Human   828 EKFPFSKDEDCLEQQMPSLRESPMTLKELSL---------FNRKPLD-----LEKSSESLASKLS 878

  Fly   828 RVR 830
            |::
Human   879 RLK 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	103/376 (27%)
		mutL	33..880	CDD:234630	219/972 (23%)
MLH3	NP_001035197.1	HATPase_MutL-MLH-PMS-like	9..192	CDD:340403	62/187 (33%)
		MutL_Trans_MLH3	206..349	CDD:239568	38/184 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..650		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	933..960
		MutL	<1194..1409	CDD:440092