Protein Alignment Pms2 and pms1

DIOPT Version :9

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001342828.1
• Gene: pms1 / 2542582
• PomBaseID: SPAC19G12.02c
• Length: 794
• Species: Schizosaccharomyces pombe
• Alignment Length: 899
• Identity: 284/899 - (31%)
• Similarity: 452/899 - (50%)
• Gaps: 153/899 - (17%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            :|.|..:||||||||||:..:|.|||||||||:|:|||.:||:.|:.|:.|:||.|||||::..:
pombe     4 VKPIDANTVHKICSGQVITDVASAVKELVENSLDSGATTIEIRFKNYGINSIEVVDNGSGIDAGD 68

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQT-RHKSTDVGVKVELDHEGRI 155
            .|.:..|:.||||.:|.||..::||||||||||||||:..::|.| .......||::.|||||.:
pombe    69 YESIGKKHFTSKITDFEDLEALQTFGFRGEALSSLCAVGQVIISTATQNEAPKGVQLNLDHEGSL 133

  Fly   156 KKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLVTKGVRILCSNHTPK 220
            |.:.......||:|::.:||.||||||:...:|.|:||:|...:||||..::...|.:..:.|..
pombe   134 KDKLTIPFQRGTSVMVNDLFCTLPVRRKLLEKNYKREFSKAISLLQAYATISTNKRFMVYHQTKN 198

  Fly   221 GAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSPQ 285
            ..|.:.|.|:.::::..||..:||.:.::.|:|..
pombe   199 SGKLLQLSTNSNKDMKLNIMNVFGTKVSSSLIPWN------------------------------ 233

  Fly   286 ISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNEVYHRYNVQQQ 350
                        |..:||:||....|:.|:|.:||..|:|.|..:...||:|:.||:..|::.|.
pombe   234 ------------DGIIEGYISRPHVGSTRASNERQMLFINRRLVNLPKIARVIQEVFKPYSMAQS 286

  Fly   351 PFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKS---LLDTFGQTPATFQMQNTTIVSM 412
            ||..:|:......:|:|::|||:.:.::.|..::..:|.|   |.::.|...:..:.|:....|.
pombe   287 PFFAINLRITNGTIDINVSPDKKSVFLSEEDSIIEFIKNSLQNLCESCGHAISCSRSQSIFSYSS 351

  Fly   413 LEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVKRRCS 477
            ..|           :||.|...:|: .:.:|.|.::...|....::|:          |.||:..
pombe   352 QIP-----------DSSGDSTDQEL-PQSIPATESETSDDSSFSYKRS----------PCKRKLV 394

  Fly   478 E---------------SEELVTRTL--KMQKIHTFLSQESP--------NEQSSKCEAESDAASD 517
            |               |...|::.|  ::||  ..:.:.||        :|:..|..|...:::|
pombe   395 EATAQPAISTSVAEGASLAQVSKPLPERLQK--DSMRRSSPLNEKVTASSERMKKKLALFASSTD 457

  Fly   518 VDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNTPRID-CKVLTPIKSRRSIFEFKTDAM 581
            ..|.|      ::|:||...:.:.|.|      :.|.|....| ....||:....::.|.:
pombe   458 TSMQK------TIDSSFPLKQPINKPS------SNPNNLLLNDPSPASTPVAKTINLNEIE---- 506

  Fly   582 ALDKQESPAELNSQPPSFTQLSEETDIASDEDDHIELPTRIE-------FDEEMEEGLPSNFSSG 639
            ::...||.:.|:|.|     .:|:|.:|:      .:|::..       |.....:||  |..|.
pombe   507 SVHNAESVSTLSSIP-----RTEQTSVAN------RIPSKTAALQKLKFFQSRPLDGL--NKFSK 558

  Fly   640 EITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAE---LQREIDKEDFARM 701
            :|..||..:          |:|......|  |:|..:|....:.|.|.:   |...:.|.||.||
pombe   559 KINISLSGV----------QKDIVRSDAL--LKFSNKIGVVHDISDENQEDHLNLTVHKADFLRM 611

  Fly   702 EIIGQFNLGFIIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLN 766
            .::||||.|||:|...::|||:||||:|||:|:|.|:....:..|.|.:|:.|:|.|..|.||::
pombe   612 RVVGQFNRGFIVVVHGNNLFIIDQHASDEKFNYEHLKSNLVINSQDLVLPKRLDLAATEETVLID 676

  Fly   767 HIDVFEKNGFKFEVDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQDAPEGTICRP--SRV 829
            |||:..:.||...:|.......:..||..|.||...|...|:.|:|.:|.:.|:   ..|  ||:
pombe   677 HIDLIRRKGFGVAIDLNQRVGNRCTLLSVPTSKNVIFDTSDLLEIISVLSEHPQ---IDPFSSRL 738

  Fly   830 RAMFASRACRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLINI 883
            ..|.||:|||.|||||.||: .:.|..::..:.|:.:||||||||||||||:.:
pombe   739 ERMLASKACRSSVMIGRALT-ISEMNTIVRHLAELSKPWNCPHGRPTMRHLLRL 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	MutL	26..880	CDD:223400	282/894 (32%)
		HATPase_c	46..>151	CDD:294057	54/105 (51%)
		MutL_Trans_hPMS_2_like	238..381	CDD:239566	34/142 (24%)
		MutL_C	703..847	CDD:214857	61/145 (42%)
pms1	NP_001342828.1	MutL	1..793	CDD:223400	284/899 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	115	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E1_COG0323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I386
OMA	1	1.010	-	-		QHG53578
OrthoFinder	1	1.000	-	-		FOG0003329
OrthoInspector	1	1.000	-	-		oto102054
orthoMCL	1	0.900	-	-		OOG6_101943
Panther	1	1.100	-	-	LDO	PTHR10073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R938
SonicParanoid	1	1.000	-	-		X2695
TreeFam	1	0.960	-	-
	13	12.860