Protein Alignment Pms2 and mlh1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_596199.1
• Gene: mlh1 / 2539949
• PomBaseID: SPBC1703.04
• Length: 684
• Species: Schizosaccharomyces pombe
• Alignment Length: 549
• Identity: 123/549 - (22%)
• Similarity: 223/549 - (40%)
• Gaps: 133/549 - (24%)

  Fly    26 QIKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEM 90
            :|:.:.:..::||.:|:::.....|:|||:|||:|||:|.:::.|||.||:.::::|||||::..
pombe     8 KIRPLDQLVINKIAAGEIIERPENAIKELIENSLDAGSTSIDVLLKDGGLKLLQITDNGSGIQYD 72

  Fly    91 NLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRI 155
            :|..:..::.||||..|.||..::|||||||||:|:..::.:.:.|: .|:|:........:|.:
pombe    73 DLPYLCQRFSTSKIDNFNDLQHLQTFGFRGEALASISHVAKVTVVTK-LSSDIHAWKAFYVDGAL 136

  Fly   156 KKRS--------PCARGVGTTVLLANLFSTLPVR-RRDFTRNIKKEFTKMCQILQAYCLVTKGVR 211
            ...|        |||...||.:...:||..  || |:...:|..:||.::..::|.|.:....|.
pombe   137 APISPGMSPAPQPCAGKQGTVITAEDLFYN--VRSRKSALKNGSEEFRRIMILVQKYAIHNDQVS 199

  Fly   212 ILCSNHTPKGAKTIVLQTHGDQEVMAN-ISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESG 275
            ..|.    |...|:...:...:...|: |..|:|.|.|:.|.......||..:
pombe   200 FNCK----KVGDTVASLSLSSRLSKADKIRHIYGPRVASHLRDFSLGEGQSSI------------ 248

  Fly   276 ADLADTTSPQISTEDVERLNQADFQLEGFISSCRHGAGRSSRDRQFFFVNSRPCDPKNIAKVMNE 340
                                 ..|...||||:...   :..:.....|:|:|..:...:...:.|
pombe   249 ---------------------VGFSANGFISNADF---QDKKSNLILFINNRLVESVELRHALEE 289

  Fly   341 VYHRY-NVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQM 404
            .|.:| :.....|:||::..:...:|||:.|.||
pombe   290 TYAKYLHKGASYFVYLSLNMSPEQLDVNVHPSKR------------------------------- 323

  Fly   405 QNTTIVSMLEPKTNSGKTKFPKESSKDDQHEEVSEEDVPTTSTQRFMDVL--TQWRRTGDTKGTA 467
                ||..|                        .::::.|:...:..::|  |...|:...:...
pombe   324 ----IVHFL------------------------YDQEIATSICDKLGEILERTDTERSYPLQAMI 360

  Fly   468 PSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKC------------EAESDAASDVDM 520
            ||:...:....|.:...||.:     .:|.:..|.|:|.|.            ..:::....||.
pombe   361 PSISNTKNAESSSQKAVRTYE-----NYLVRTDPRERSIKSMLSDNFLQRSSNNYDNEIIEKVDS 420

  Fly   521 AKKDKTQVSLDNSFLNLKELAKESEAYDL 549
            |..:|...: |...|..:|:.:|..:.||
pombe   421 ANSNKNATN-DIKDLQTEEIVEEGNSIDL 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	96/360 (27%)
		mutL	33..880	CDD:234630	122/542 (23%)
mlh1	NP_596199.1	mutl	8..326	CDD:273155	97/395 (25%)
		Mlh1_C	447..684	CDD:465109	2/2 (100%)