Protein Alignment Pms2 and Pms1

DIOPT Version :10

• Sequence 1: NP_477023.1
• Gene: Pms2 / 36705
• FlyBaseID: FBgn0011660
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_705784.1
• Gene: Pms1 / 227099
• MGIID: 1202302
• Length: 917
• Species: Mus musculus
• Alignment Length: 999
• Identity: 238/999 - (23%)
• Similarity: 410/999 - (41%)
• Gaps: 228/999 - (22%)

  Fly    27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSGVEEMN 91
            :|.:...||..:.|.|.:.|:...||||:|||:|||||.:|:||::.|...:|:.|||.|::.::
Mouse     1 MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKLENYGFDKIEIRDNGEGIKAVD 65

  Fly    92 LEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVKVELDHEGRIK 156
            :..|..||:||||....||..:.|:|||||||.|:|.::::|:.||..:.|...:..||..|.|.
Mouse    66 VPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICNVAEVVVTTRTSADDFSTQYVLDGSGHIL 130

  Fly   157 KRSPCARGVGTTVLLANLFSTLPVRRRDFT--RNIKKEFTKMCQILQAYCLVTKGVRILCSNHTP 219
            .:.|...|.||||....||..||||::.::  :..|.|...:..:|.:|.::...|||...::
Mouse   131 SQKPSHLGQGTTVTALKLFKNLPVRKQFYSTAKKCKDELKNVQDLLISYGVLKPDVRITFVHN-- 193

  Fly   220 KGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEAELRADLESGADLADTTSP 284
               |.::.|.          |.:...|.|     |.|..|                      |:.
Mouse   194 ---KAVIWQK----------SRVPDHRMA-----LMSVLG----------------------TAV 218

  Fly   285 QISTEDVER-LNQADFQLEGFISSCRHGAGRSSR-----DRQFFFVNSRPCDPKNIAKVMNEVYH 343
            ..:.|.||: ..|:...|.||..  :|.|..:|.     :|.|.|:||||...|:|.|::...|:
Mouse   219 MGNMESVEQHCEQSQIYLSGFFP--KHDADHNSTSLSTPERSFIFINSRPVHQKDILKLIRRYYN 281

  Fly   344 ----RYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILLLALKKSLLDTFGQTPATFQM 404
                :.:.:..|..:|.|....::||:||||||.|:|:.|:..:|:||:..::..:|..|.|...
Mouse   282 LKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLMMTCYGPLPTTESS 346

  Fly   405 QNTTI----VSMLEPKTNSGKTKFPKESS----------------KDDQHEEVSEEDVPTTSTQR 449
            :|..:    .:|:..:|......|.|..|                ||:..:.:........:...
Mouse   347 ENNRVDISSANMVVSQTAETDVLFNKMESFGNNYPNADTSAIHFQKDESRKNIDHHLNEQINIGN 411

  Fly   450 FMDVLTQWRRTGD-TKGTAPSVPVKRRCSESEELVTRTLKMQKIHTFLSQESPNEQSSKCEAESD 513
            :.|    ...:|| .|.|..::|:....||     |......:.|:..|.|....::.: .....
Mouse   412 YFD----GHFSGDINKDTFQNIPMNNLSSE-----TNQSNHSETHSVGSMEHIQGENGR-NGTGG 466

  Fly   514 AASD---------VDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKPQNT---------PRID 560
            :..|         :::...|.::.:|.||      :.:..|...:|. ||.:         ||::
Mouse   467 SGGDGRETLPEKALEICADDWSKGNLCNS------MGENIEPVKILV-PQKSLSCKVTSSHPRLE 524

  Fly   561 CKVLT--PIKSRRSIFEFKT------------------DAMALDKQESPAELNSQPPSFTQLSEE 605
            .:.|:  |......:...::                  .|.||..|:...:..::.|. |.|.:.
Mouse   525 PETLSDGPCSRTSDVIHNRSGRLTAYDLISSRAVKKPMSASALFIQDHRTQFLTENPK-TGLEDA 588

  Fly   606 T-------DIASDEDDH--------------------IELPTRIEFDEEMEEGLPSNF------- 636
            |       :..|:|:.|                    ||..|::...:..::...|::
Mouse   589 TEQIKARWETLSEEEKHKYEEKAKKDLERYNNQMKKAIEQETQVSLKDGRKKRATSSWGWTQKHK 653

  Fly   637 ---SSGEITTSLEEIASSLKAHEQQQRDRRTRTKLQRLRFKTEINPNQNTSAEAELQREIDKEDF 698
               ||.:  ..|:|:..|     |.::.:....|:..:.|..|     |..|..:.|:|:|.|:
Mouse   654 VKDSSNQ--PKLDELFQS-----QNEKKKSENIKITEIPFSME-----NLKANLKKQKEVDLEE- 705

  Fly   699 ARMEIIGQFNLGF---IIVKLEDDLFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVN 760
             :.||....:|.|   .:|....|:.:::.:..:|...|:.|....:|    ||.|  ||...:.
Mouse   706 -KDEIYLIHSLKFPDSWLVTSRADVMLLNPYRVEEALLFKRLLENHKL----LAEP--LEKPIIL 763

  Fly   761 EMVLLN---HIDVFEK---------------------NGFKFEVDHEAPATKK-VRLLGKPHSKR 800
            ...|||   :::|..|                     ||||..:.....:|:. :.:.|......
Mouse   764 TESLLNGSHYLEVLYKMSTVEERGSGSAYLCDPRLTANGFKIRLTPGVSSTENYLEIEGMAQCLP 828

  Fly   801 WEFGKEDIDELI--FMLQDAPEGTICRPSRVRAMFASRACRKSVMIGTALSRNTT---MRRLITQ 860
            : :|..|:.|::  .:.::|.|...|||.:|.......|.|.|..:...|.|...   :.|:..|
Mouse   829 F-YGIMDLKEILNAIVNKNAKEIYECRPRKVINYLEGEAVRLSRQLPMYLPREDVQDLIYRMKHQ 892

  Fly   861 MG-EIEQPWNCPHGRPTMRHLINI 883
            .| ||:   .|.||||...||.::
Mouse   893 FGKEIK---GCVHGRPFFHHLTHL 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pms2	NP_477023.1	mutl	25..376	CDD:273155	115/360 (32%)
		mutL	33..880	CDD:234630	235/988 (24%)
Pms1	NP_705784.1	mutl	1..318	CDD:273155	115/360 (32%)
		HMG-box_SF	558..629	CDD:469606	13/71 (18%)
		NHP6B	<559..708	CDD:227935	30/163 (18%)